Search Results - stephen+johnston

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Synbodies - High Throughput Development of Synthetic Antibodies
The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the immunized...
Published: 2/23/2023   |   Inventor(s): Stephen Johnston, Neal Woodbury, John Chaput, Chris Diehnelt, Hao Yan
Keywords(s):  
Category(s): Life Science (All LS Techs), Diagnostic Assays/Devices, Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools
High-throughput selection of pathogen specific antimicrobials from random sequence peptide microarrays
Antimicrobial resistance is one of the biggest healthcare challenges. Overuse and misuse of conventional antibiotics along with their broad spectra have triggered development of multi-drug resistant superbugs. Researchers at Arizona State University have developed a novel process for producing alternative antimicrobial agents specific for any particular...
Published: 2/23/2023   |   Inventor(s): Valeriy Domenyuk, Chris Diehnelt, Stephen Johnston
Keywords(s): Antigen-specific Therapies
Category(s): Bioanalytical Assays, Chemistries & Devices, Proteomic Assays/Reagents/Tools, Vaccines/Antimicrobials, Life Science (All LS Techs)
Synbodies for Detection of Human Norovirus
Noroviruses are hardy, highly contagious viruses that are the most common cause of acute gastroenteritis in humans. The CDC estimates that there are about 21 million illnesses caused by Noroviruses each year and about 800 of those result in death. There is no available vaccine for Norovirus infection and vaccine progress is hampered by the absence of...
Published: 2/23/2023   |   Inventor(s): Nidhi Gupta, Chris Diehnelt, Charles Arntzen, Stephen Johnston
Keywords(s): ELISA, Human Norovirus (HuNoV), Peptide Affinity Reagents, Peptide Microarray, Synthetic Antibody (Synbody)
Category(s): Life Science (All LS Techs), Medical Diagnostics/Sensors, Proteomic Assays/Reagents/Tools, Vaccines/Antimicrobials
High Affinity Synbodies for Influenza
Highly virulent strains of influenza virus are a critical public health concern with 3,000-5,000 people dying each year from influenza infection in the United States alone. Influenza is a continually evolving pathogen that develops resistance easily, including to recently approved antivirals. Rapidly diagnosing and typing influenza is essential in surveillance...
Published: 2/23/2023   |   Inventor(s): Chris Diehnelt, Nidhi Gupta, Valeriy Domenyuk, Zhan-Gong Zhao, Stephen Johnston
Keywords(s): Diagnostics, Influenza, Peptide Affinity Reagents, Therapeutics
Category(s): Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Pharmaceuticals, Non-Cancer Therapeutics, Diagnostic Assays/Devices, Bioanalytical Assays, Chemistries & Devices
Antibacterial Peptides, Synbodies, and Methods of Discovery
Antibiotic resistance is a worldwide clinical and public health problem, primarily stemming from the overuse of antibiotics. One of the most critical resistant pathogens is Methicillin-resistant Staphylococcus aureus (MRSA), which accounts for over 2,000,000 illnesses and 11,000 deaths each year. MRSA has developed resistance to all beta-lactam antibiotics....
Published: 2/23/2023   |   Inventor(s): Chris Diehnelt, Stephen Johnston
Keywords(s): Antibiotic Resistance Treatments, Antibiotics, Anti-Infectives, Infectious Disease, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Vaccines/Antimicrobials, Pharmaceuticals, Proteomic Assays/Reagents/Tools
Antibacterial Peptides, Synbodies, and Methods of Discovery
Antibiotic resistance is a worldwide clinical and public health problem, primarily stemming from the overuse of antibiotics. One of the most critical resistant pathogens is Methicillin-resistant Staphylococcus aureus (MRSA), which accounts for over 2,000,000 illnesses and 11,000 deaths each year. MRSA has developed resistance to all beta-lactam antibiotics....
Published: 2/23/2023   |   Inventor(s): Chris Diehnelt, Stephen Johnston, Pamela Hall
Keywords(s): Antibiotic Resistance Treatments, Antibiotic Resistant Bacteria, Antibiotics, Anti-Infectives, Drug Discovery, Infectious Disease, Peptides, Therapeutics
Category(s): Life Science (All LS Techs), Non-Cancer Therapeutics, Proteomic Assays/Reagents/Tools, Pharmaceuticals, Vaccines/Antimicrobials
Immobilization of Proteins on a Functionalized Surface for Natural Conformation and Optimal Activity
Two-dimensional microarrays have proven useful for a wide range of applications, from ELISA microarrays to basic protein research. However, attaching an antibody, enzyme, or other protein to a functionalized surface is not without its problems. Antibodies are costly and time-consuming to produce and screen, and the process of attaching a protein often...
Published: 2/23/2023   |   Inventor(s): Stephen Johnston, Chris Diehnelt
Keywords(s):  
Category(s): Life Science (All LS Techs), Proteomic Assays/Reagents/Tools, Bioanalytical Assays, Chemistries & Devices, Diagnostic Assays/Devices