Search Results - stroke

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Stimulation of Parvalbumin Neurons to Enhance Recovery After Stroke (UCLA Case No. 2024-131)
UCLA researchers from the Department of Neurology have discovered a molecular compound that promotes activation of parvalbumin neurons in the brain, enhancing behavioral recovery after stroke. BACKGROUND: Stroke is a leading cause of death and disability worldwide. According to the World Health Organization, approximately 15 million people suffer from...
Published: 8/28/2024   |   Inventor(s): Stanley Carmichael
Keywords(s): Cns, Neurology, neuroscience, parvalbumin neurons, spinal cord, Stroke, stroke rehabilitation, stroke therapeutics
Category(s): Therapeutics > CNS and Neurology
Isotropic Generalized Diffusion Tensor MRI
Abstract: Scientists at the Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD) have developed a method implemented as pulse sequences and software to be used with magnetic resonance imaging (MRI) scanners and systems. This technology is available for licensing and commercial development. The method allows for measuring...
Published: 4/8/2024   |   Inventor(s): Alexandru Avram, Peter Basser
Keywords(s): ADC, Basser, Central Nervous System, CNS, diffusion, Diffusion Weighted Images, Distribution, DWI, Fetus, High-Order Tensor, Image Analysis, Isotropic Diffusion Tensor Imaging, mADC, Mean Apparent Diffusion Coefficient, MRI Pulse Sequences, PATHOLOGY, Peripheral Nervous System, Placenta, PNS, STROKE, TRACE, Whole-Body
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology, Application > Software / Apps
The preparation of a brain targeted artificial nano-enzyme and application
Reference #: 01514 The University of South Carolina is offering licensing opportunities for The preparation of a brain targeted artificial nano-enzyme and application Background: Chronic neuroinflammation is caused by the activation of microglia, which is the major cause of central neuronal system (CNS) diseases, including Alzheimer’s disease,...
Published: 4/25/2024   |   Inventor(s): Peisheng Xu, Haijun Liu
Keywords(s): Alzheimer’s disease, Amyotrophic lateral sclerosis, brain injury, Brain targeted nanoparticle, Brain tumor, Epilepsy, frontotemporal dementia, glioblastoma, Huntington's disease, Multiple sclerosis, neonatal hypoxic-ischemic, neuroblastoma, Parkinson's disease, post-traumatic stress disorder, Spinal cord injury, stroke
Category(s): Nanotechnology, Health Sciences, Biomedical and Life Sciences
Furoxans as Novel Therapeutics for Neurodegenerative Disorders
Project ID: D2017-15 Background Nitric oxide (NO) signaling plays a major role in brain activity and normal function of neurons. Disrupted NO signaling is implicated in several central nervous system (CNS) and neurodegenerative disorders. NO mimetic, such as nitrates, have been used against a variety of neurological disorders. This is due to the...
Published: 5/9/2024   |   Inventor(s): Isaac Schiefer, Zahoor Shah
Keywords(s): Alzheimer's, Depression, Encephalopathy, Furoxan, Neurodegenerative, Nitrate, NitricOxide, Stroke, Traumatic
Category(s): Neuroscience
Cofilin inhibitor for the treatment of hemorrhagic brain injury-induced inflammation
Project ID D2019-35 Background Cofilin regulates actin filament assembly and organization in most cells, including during macrophage, T-cell, and dendritic activation and migration. Over-activation of cofilin can lead to microglia inflammation in the brain. Although Cofilin has been shown to be involved in the secondary injury of intracerebral hemorrhage...
Published: 6/18/2024   |   Inventor(s): Zahoor Shah, Saleh Alaqel, Liyanaaratchige Tillekeratne
Keywords(s): Cofilin, Hemorrhagic, Stroke
Category(s): Cardiovascular, Renal, & Metabolism, Neuroscience, Inflammation & Immunity
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Published: 6/18/2024   |   Inventor(s): Steven Sucheck, Donald Ronning, Sandeep Thanna, Alexander Landgraf
Keywords(s): Antibiotics, Anti-inflammatory, Antioxidant, Bipolar, Cancer, Cytoprotective, Hearing, Neurodegenerative, Reperfusion, Stroke
Category(s): Inflammation & Immunity