Search Results - peptide

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Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)
Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...
Published: 10/8/2024   |   Inventor(s): Dino Di Carlo, Owen Witte, Doyeon Koo, Zhiyuan Mao
Keywords(s): Cancer Immunotherapy, CAR-T cell therapy, Flow Cytometry, hydrogel, Immunooncology, Immunotherapy, Peptide, single cell analysis, T Cell, T cell based therapy
Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Therapeutics > Immunology And Immunotherapy
Targeting Prostate Cancer with a Novel T-Cell Receptor and Tissue-Specific Cancer Antigens for Improved Immune Response (UCLA Case No. 2022-070)
Researchers from UCLA’s Department of Microbiology, Immunology, & Molecular Genetics (MIMG), and the department of Molecular and Medical Pharmacology have identified a set of tissue-specific antigens which have been used to isolate and characterize a group of novel T-cell receptors (TCRs) which target prostate cancer specifically. Furthermore,...
Published: 11/15/2024   |   Inventor(s): Owen Witte, Zhiyuan Mao, Jami Witte, Pavlo Nesterenko, John Lee
Keywords(s): Cancer, cancer antigen, Peptide, peptides, prostate cancer, protein, t-cells
Category(s): Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Peptide Hydrogels for Rate-Controlled Delivery of Therapeutics
Abstract: Hydrogels represent an attractive controlled drug-delivery system that have been used in various clinical applications, such as: tissue engineering for wound healing, surgical procedures, pain management, cardiology, and oncology. High-water content of hydrogels confers tissue-like physical properties and the crosslinked fibrillar network...
Published: 4/8/2024   |   Inventor(s): Joel Schneider, Stephen Miller, Yuji Yamada, Steven Tau, Julie Hixon, Wenqing Li, Caroline Andrews, Scott Walsh
Keywords(s): DEVICE, IL-7, Nanoparticle, Peptide, Peptide-based Hydrogel, Protein, Schneider, small molecule, T Cell Enhancer, Whole Cell Delivery System
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, TherapeuticArea > Immunology
A peptide hydrogel for use in vascular anastomosis
Abstract: In collaboration with surgery specialists from Johns Hopkins University, researchers at the National Cancer Institute (NCI) developed novel hydrogel compositions and methods of using them in the microsurgical suturing of blood vessels, which is particularly beneficial for surgeons in whole tissue transplant procedures. The lead candidate electropositive...
Published: 12/6/2024   |   Inventor(s): Joel Schneider, Gerald Brandacher, Daniel Smith, Gabriel Brat, Johanna Grahammer
Keywords(s): Anastomosis, Hydrogel, Microsurgery, Peptide, Schneider, Surgery
Category(s): TherapeuticArea > Oncology, TherapeuticArea > Endocrinology, Application > Non-Medical Devices, TherapeuticArea > Reproductive Health, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Medical Devices, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Gastroenterology, TherapeuticArea > Cardiology, TherapeuticArea > Nephrology, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology
Peptide Inhibitors for Viral Infections and as Anti-inflammatory Agents
Abstract: IFN-gamma and IL-10 are cytokine signaling molecules that play fundamental roles in inflammation, cancer growth and autoimmune diseases.  Unfortunately, there are no specific inhibitors of IFN-gamma or IL-10 on the market to date. NCI investigators at the Cancer and Inflammation Program have synthesized short peptides that selectively interfere...
Published: 4/8/2024   |   Inventor(s): Nadya Tarasova, Giorgio Trinchieri, Howard Young, C. Andrew Stewart, Marco Cardone, Alan Perantoni
Keywords(s): IFN-gamma, Interferon gamma, INTERLEUKIN, Peptide, Peptidometic, psoriasis, Synthetic Peptide Inhibitors
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Immunology
Treatment of Chronic Kidney Disease with Synthetic Amphipathic Peptides
The invention is directed to treatment of chronic kidney disease by administering a synthetic, amphipathic helical peptide known as 5A-37pA, and novel derivatives thereof. Scientists at NIDDK have demonstrated that invention peptides antagonize activity of a particular scavenger receptor known as CD36. Using an in vivo model, NIDDK scientists have shown...
Published: 10/28/2024   |   Inventor(s): Peter Yuen, Robert Star, Alexander Bocharov, Alan Remaley, Thomas Eggerman, Ana Souza
Keywords(s): 5A-37pA, AMPHIPATHIC, Chronic, Disease, HELICAL, KIDNEY, Peptide, treatment, VDXXXX, VFXXXX, VGXXXX, VHXXXX, VIXXXX, VPXXXX, WIXXXX, WJXXXX, XHXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Ophthalmology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Research Materials
Recombinant Sulfated HIV Envelope Protein and Methods for Making Protein
This technology comprises sulfated recombinant gp120 proteins and peptides. Also included are methods for producing sulfated recombinant gp120 proteins. The focus of this technology is on sulfation of two tyrosines in the V2 loop of the HIV major envelope glycoprotein, gp120, which increase the stability of gp120 and promote the synthesis of gp120 protein...
Published: 10/28/2024   |   Inventor(s): Raffaello Cimbro, Paolo Lusso
Keywords(s): BETWEEN, CD4, DB4XXX, DBXXXX, DC5XXX, DCXXXX, DXXXXX, Envelope, gp120, HIV, INHIBIT, INTERACTION, Mimics, Peptide, Protein, RECEPTOR, That, V2-loop, VLXXXX, WIXXXX, WJXXXX, WKXXXX, YAXXXX, YBXXXX, YCXXXX, YFXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Therapeutics, Application > Vaccines
Multiple Antigenic Peptide Assays for Detection of HIV and SIV Type Retroviruses
CDC scientists have developed multiple antigenic peptide immunoassays for the detection of human immunodeficiency virus (HIV) and/or simian immunodeficiency virus (SIV). HIV can be subdivided into two major types, HIV-1 and HIV-2, both of which are believed to have originated as result of zoonotic transmission. Humans are increasingly exposed to...
Published: 10/28/2024   |   Inventor(s): Clement Ndongmo, Chou-Pong Pau, William Switzer, Thomas Folks, Marcia Kalish
Keywords(s): ANTIGENIC, assay, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4AXX, DA4BXX, DA4XXX, DAXXXX, DDXXXX, Detection, DXXXXX, HIV, MULTIPLE, OID-NCHHSTP-DHPSE, Peptide, Retroviruses, Serologic, SEROLOGICAL, SIV, TYPE, VLXXXX, VOXXXX, WBXXXX, WFXXXX, WIXXXX, WMXXXX, XAXXXX, XCXXXX, XEXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Consumer Products, TherapeuticArea > Infectious Disease, Application > Research Materials, Application > Occupational Safety and Health, Application > Diagnostics, ResearchProducts > Antibodies, Application > Therapeutics
Improved Botulism, Botulinum Neurotoxin Type-E Diagnostics
CDC researchers have improved upon a prior, HHS patented mass spectrometry-based Endopep-MS assay that is able to rapidly detect and differentiate all seven botulinum neurotoxin (BoNT) types A to G. This current improvement comprises the addition of two optimized substrate peptides that increases the assay's sensitivity,relative to prior substrates,...
Published: 10/28/2024   |   Inventor(s): Suzanne Kalb, John Barr, Dongxia Wang
Keywords(s): AAXXXX, ACXXXX, BACTERIA, Bacterial, Biodefense, Biodetection, Bolulinum, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DA5XXX, DAXXXX, DXXXXX, e, MASS SPECTROMETER, Mass spectrometry, Neurotoxin, Novel, Peptide, Recognizable, SUBSTRATES, toxin, TYPE, VBXXXX, VJXXXX, VKXXXX, VLXXXX, WAXXXX, WBXXXX, WCXXXX, WFXXXX, WIXXXX, WMXXXX, XCXXXX, XDXXXX, XHXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Consumer Products, Application > Non-Medical Devices, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Research Materials, Application > Diagnostics, Application > Occupational Safety and Health
Peptide Vaccines Against Group A Streptococci
This invention relates to synthetic immunoreactive peptides, which are portions of the M proteins of the most prevalent Group A Streptococcus (GAS) serotypes in the United States. These peptides may be useful in development of a flexible, multivalent GAS vaccine. They can be recognized by M type-specific antibodies and are capable of eliciting functional...
Published: 10/28/2024   |   Inventor(s): George Carlone, Jacquelyn Sampson, Edwin Ades, Bernard Beall
Keywords(s): Against, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DCXXXX, GROUP, OID-NCIRD-DBD, Peptide, Streptococci, vaccines
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease
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