Search Results - antimicrobial

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A Human Monoclonal Antibody Against Deacetylated PNAG for Use as an Antimicrobial Agent
Abstract: Biofilms are complex microbial communities, surface attached and held together by self-produced polymer matrices.  These matrices are mainly composed of polysaccharides, secreted proteins and nucleic acids.  Poly-N-acetyl glucosamine (PNAG) is a highly conserved surface polysaccharide expressed by a range of bacterial, fungal and protozoan...
Published: 5/22/2024   |   Inventor(s): Jeffrey Gildersleeve, Joel Temme
Keywords(s): ANTIMICROBIAL, Biofilm, Deacetyleated Poly-N-Acetyl Glucosamine, dPNAG, Gildersleeve, Mab, Monoclonal Antibody, TG10
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing
Combining Aminoglycoside Antibiotics and PKZ18 Analogs
Significantly enhances the efficacy of aminoglycosides drugs while reducing the risk of microbial drug resistance. Background: To increase drug efficacy and reduce the risk of the development of resistance to treatment, clinicians often prescribe multiple drugs of different classes in combination. For example, many topical creams use an aminoglycoside...
Published: 1/24/2024   |   Inventor(s): Ville Väre, Ryan Schneider
Keywords(s): antibiotics, antimicrobial, drug development, Staphylococcus aureus, synergistic interaction, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
New Method for Discovery of Bioactive Molecules
INV-20024 Background Microbes are a foundation of the discovery of bioactive molecules because they produce an enormous variety of secondary metabolites, some with desirable activities ranging from antibiotics to anti-inflammatory to anticancer to industrial enzymes. The advent of next-generation sequencing technologies uncovered that microbial genomes...
Published: 9/10/2024   |   Inventor(s): Slava Epstein
Keywords(s): Antimicrobial, Biomolecules, Cancer, Drugs, Microbiology
Category(s): -Method, Antimicrobial, Technology Classifications > 1. Life Science > Gene sequencing, Technology Classifications > 1. Life Science > Drug Discovery
Poly (ionic liquid) surgical and tissue adhesive
TechnologyThis is a new method to improve the adhesion properties of any biomaterial. This method is very general and applicable with wide range of materials. This method is simple and easy to use. Dr. Iman Noshadi in the Department of Chemical Engineering has developed a modified hydrogel to make antimicrobial, highly adhesive for surgical applications....
Published: 11/1/2024   |   Inventor(s): Iman Noshadi
Keywords(s): Adhesive, Antimicrobial, Hydrogels, Surgical, Tissue Engineering
Category(s): Human Health Care > Biomaterials
Use of Silver-containing Layers in and on Implant Surfaces
BackgroundMedical devices implanted in the human body can react with internal bio fluids and cause infection or compromise the health of surrounding bone and/or tissue. Treating infections with antibiotics is not always desired because it can be difficult to direct the antibiotic to the specifically needed location, treatment can take between 3 to 14...
Published: 11/2/2024   |   Inventor(s): Greg Caputo
Keywords(s): Antimicrobial, Biomedical, Coatings, Implant, Medical Devices
Category(s): Human Health Care > Biomaterials, Human Health Care > Medical Devices
Mouse Model for Vitamin D Regulated Antimicrobial Peptide Expression
Technology Description Oregon State University is seeking collaborative research opportunities or licensees for a humanized mouse model for vitamin D regulated antimicrobial peptide expression. The developed animal model is a transgenic mouse that carries a 6.2 kb human genomic DNA that possess the cathelicidin antimicrobial peptide (CAMP) gene. Vitamin...
Published: 1/16/2023   |   Inventor(s): Adrian Gombart
Keywords(s): Animal Model, Antimicrobial, Biotechnology, Vitamin D regulation
Category(s): Therapeutics, Biological Materials, Research Tools
Peptide Inhibitors of Gonorrhoeae
Technology Description Antigonococcal peptide inhibitors of Neisseria gonorrhoeae that act against a non-conventional new target, nitrite reductase AniA, that is necessary for N. gonorrhoeae anaerobic respiration and biofilm formation. The anaerobic life style is an important state during disease and favored in biofilms, which form in cervical gonococcal...
Published: 12/23/2021   |   Inventor(s): Aleksandra Sikora, Konstantin Korotkov
Keywords(s): Antibiotics, Antimicrobial, Drug, Drug Development, Gonorrhea, Inhibitor, Microbiology, Peptide, Therapeutic
Category(s): Therapeutics, Vaccines
Antimicrobial Surface Coating
Background of Invention Advances in biomaterials engineering have led to numerous successful technologies in the medical field and have improved the quality of life for millions of people. However, there are still problems with blood coagulation, fibrosis, and infections associated with currently available materials. Most materials used in medical...
Published: 6/17/2024   |   Inventor(s): Joseph Mcguire, Pranav Joshi
Keywords(s): Advanced Technology and Manufacturing Inst. (ATAMI), Antimicrobial, Peptide, polymer
Category(s): Engineering
Development of Novel Antibiotic Agents to Treat Drug-Resistant Microorganisms
Project ID: D2015-58 Invention Description: The expanding populations of microbes that have developed resistance to many of the available antibiotics require new drugs which can act through novel mechanisms to thwart this increasing resistance. Our technology provides the basis for development of selective drugs that can function through a novel...
Published: 5/9/2024   |   Inventor(s): Ronald Viola, Bharani Thangavelu, Pravin Bhansali
Keywords(s): Antibiotic, Antimicrobial, Drug-resistance, Enzyme, Inhibitor, Target
Category(s): Rare Disease
Anti-Infective Antibacterial Agents against Mycobacterium Tuberculosis and other Mycobacterium Species
Project ID: D2016-53 Background Mycobacterium tuberculosis is an acid-fast gram-positive bacterium that causes tuberculosis (TB). TB ranks first for the number of deaths in humans caused by an infectious agent. It has been difficult to eradicate TB even though the infection is treatable. Treatment for TB takes at least 6 months and, sometimes, up...
Published: 5/9/2024   |   Inventor(s): Steven Sucheck, Sandeep Thanna, Slayden Richard
Keywords(s): Antibacterial, Antimicrobial, Multi-drug resistant, Mycobacterium, Tuberculosis
Category(s): Inflammation & Immunity
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