Search Results - inflammation+%26+immunity

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Pranlukast for Inhibition of Oral Microbe Biofilms
Project ID:TECH2023-37 Background Streptococcus mutans is a bacterium that lives in the oral cavity of humans and is a major cause of caries, also known as dental cavities. In order to cause caries, the bacterium must form a biofilm. The biofilm creates a microenvironment in which the enamel of teeth is degraded and caries form. True anti-biofilm...
Published: 7/30/2024   |   Inventor(s): Rudolph Sloup, Jyl Matson
Keywords(s):  
Category(s): Inflammation & Immunity, Antimicrobial
Improved resuscitation in hemorrhagic shock using polyethelyne glycol modified albumin (PEG-Alb).
Background Capillary leakage of important ions and proteins, such as albumin from blood vessels can lead to a buildup of fluid in interstitial space (organ swelling) as well as hypoperfusion of organs. Capillary leak (CL) is a central component of multiorgan failure and a secondary component to severe sepsis caused by bacterial or viral infections,...
Published: 5/9/2024   |   Inventor(s): Ragheb Assaly, J Dignam, Joseph Shapiro
Keywords(s):  
Category(s): Inflammation & Immunity
Inducing plasticity to prime immune system for CAR-Treg therapy
Project ID: D2022-28 Background Regulatory T cells (Tregs) are the critical regulators of peripheral immune tolerance; when defective, Tregs can lead to autoimmune disorders, such as Type 1 Diabetes (T1D) A more recent approach to prevent/treat autoimmunity is to refit immune cells towards their non-inflammatory phenotype in the affected organ. Chimeric...
Published: 6/18/2024   |   Inventor(s): Shahnawaz Imam, Juan Jaume
Keywords(s): CAR-T, Chimeric Antigen Receptor, EIF5A, Notch
Category(s): Cardiovascular, Renal, & Metabolism, Inflammation & Immunity
Osteoanabolism by 14-3-3zeta
Project ID: D2021-48 Background Bone loss is one of the common symptoms associated with normal aging and pathologies. An increased bone mass loss and mineral density are the primary reason for osteoporosis, arthritis, fractures, etc. Together it affects millions of individuals in the US alone. While several drugs targeting the prevention of bone...
Published: 6/18/2024   |   Inventor(s): Ritu Chakravarti, Saurabh Chattopadhyay
Keywords(s): 14-3-3z, 14-3-3 zeta, Arthritis, Autoimmune, Osteoarthritis, Rheumatoid Arthritis
Category(s): Inflammation & Immunity, Long Bone/Joint Repair
Cofilin inhibitor for the treatment of hemorrhagic brain injury-induced inflammation
Project ID D2019-35 Background Cofilin regulates actin filament assembly and organization in most cells, including during macrophage, T-cell, and dendritic activation and migration. Over-activation of cofilin can lead to microglia inflammation in the brain. Although Cofilin has been shown to be involved in the secondary injury of intracerebral hemorrhage...
Published: 11/27/2024   |   Inventor(s): Zahoor Shah, Saleh Alaqel, Liyanaaratchige Tillekeratne
Keywords(s): Cofilin, Hemorrhagic, Stroke
Category(s): Cardiovascular, Renal, & Metabolism, Neuroscience, Inflammation & Immunity
Therapeutic and Prophylactic for Arthritis
Project ID: D2019-15Background Rheumatoid Arthritis (RA) is an autoimmune disease that causes swelling of the joints. Treatments are limited to anti-inflammatories, DMARDs, corticosteroids or biologics. Genetic research has identified several genetic factors that determine susceptibility to developing RA. However, there are no prophylactics or therapeutics...
Published: 6/18/2024   |   Inventor(s): Ritu Chakravarti, Bina Joe
Keywords(s): 14-3-3z, 14-3-3 zeta, Arthritis, Autoimmune
Category(s): Inflammation & Immunity
Spontaneous Type I Diabetes Mouse Model
Project ID: D2015-60 Background Although the NOD mouse is the current standard for studies of type I diabetes (T1D), no curative therapies resulting from this model have passed clinical trials. Knock in/out models cannot be used to mimic the total pathophysiology of diabetes. In order to develop a cure for T1D, there is a need for an animal model...
Published: 6/18/2024   |   Inventor(s): Juan Jaume, Maria Alfonso-Jaume, Shahnawaz Imam
Keywords(s): Diabetes, Mouse model, NOD mouse, Type I diabetes
Category(s): Tools, Cardiovascular, Renal, & Metabolism, Neuroscience, Inflammation & Immunity
Methods for detecting exposure to cyantoxins
Project ID: D2018-46Background Harmful Algal Blooms (HAB) are becoming more frequent worldwide due to factors such as temperature increase and pollution. Microcystins (MC) are carcinogenic toxins released by the algae during a blooms. MC exposure can occur via skin contact, inhalation, and ingestion and can cause illness in people and animals. MC detection...
Published: 6/18/2024   |   Inventor(s): David Kennedy, Steven Haller, Ronald Wooten, Deepa Mukundan, Jason Huntley, Bruce Levison, John Presloid, Apurva Lad
Keywords(s): Diagnostic, ELISA, Microcystin
Category(s): Diagnostics, Tools, Inflammation & Immunity
Enhanced Immunogenicity Vaccine Development Platform
Project ID: D2012-14BackgroundExtensive research is being carried out globally to develop vaccines for the treatment of different types of infections and diseases. However, improved immunogenicity and efficient delivery of antigens to the antigen producing cells (APCs) via these vaccines is still a challenge. Also, it is very costly and time consuming...
Published: 6/18/2024   |   Inventor(s): Steven Sucheck, Katherine Wall, Sourav Sarkar
Keywords(s): Antigen, Cancer, Immune, Liposome, MUC1, Vaccine
Category(s): Oncology, Inflammation & Immunity
Novel Isoselenazolone Derivatives Show Effectiveness Against Multiple Human Disease-causing Pathogens
Project ID: D2015-17Invention Description:Neurodegenerative, inflammatory and other physiological diseases are linked to the activity of reactive oxygen species (ROS). Glutathione peroxidase is a Selenium-based enzyme that has been shown to protect biomembranes and other cellular components from damage caused by ROS, by scavenging hydrogen peroxide...
Published: 6/18/2024   |   Inventor(s): Steven Sucheck, Donald Ronning, Sandeep Thanna, Alexander Landgraf
Keywords(s): Antibiotics, Anti-inflammatory, Antioxidant, Bipolar, Cancer, Cytoprotective, Hearing, Neurodegenerative, Reperfusion, Stroke
Category(s): Inflammation & Immunity
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