Search Results - asthma

6 Results Sort By:
Suppressive Molecules of Diseases with Altered IgE Regulation
Provides a new platform for the development of diseases associated with abnormal regulation of immunoglobulin E (IgE). Background: Previous research has demonstrated that congeners of tetracycline, minocycline, and doxycycline suppress asthmatic symptoms in vivo, and immunoglobulin E (IgE) from asthmatics in vitro in a dose-dependent manner. In theory,...
Published: 5/13/2025   |   Inventor(s): Helen Durkin (Deceased), Martin Bluth, Rauno Joks, Tamar Smith-Norowitz
Keywords(s): allergy, asthma, atopy, immunoglobulin E (IgE)
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Biomedical Science and Engineering
Improved Acoustic Plethysmograph System for Noninvasive Measurement of Pulmonary Function
CDC researchers have developed a novel acoustic whole body plethysmograph (AWBP) that allows measurement of tidal volume in lab animals, independent of gas compression in the lung. This system provides particular advantages over the traditional whole body plethysmograph (WBP) when measuring model animals with increased gas compression due to increased...
Published: 4/18/2025   |   Inventor(s): David Frazer, Jeffrey Reynolds
Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC1XXX, AC2XXX, AC3XXX, AC6XXX, Acoustic, ACXXXX, ADXXXX, AE1BXX, AE1XXX, AE3XXX, AE4XXX, AEXXXX, ANIMAL, Animal Model, ANIMAL welfare, ASTHMA, Breath, BREATHING, CDC Docket Import, CDC Docket Import CDC Prosecuting, DDXXXX, DEVICE, DEXXXX, DXXXXX, FUNCTION, IA3XXX, IA5XXX, ICXXXX, IDXXXX, LUNG, lung cancer, Lung Disease, LUNGS, Lung-Targeted, Measuring, NIOSH, NIOSH-HELD, Plethysmograph, Pulmonary, Pulmonary edema, PULMONARY FIBROSIS, research, RESEARCH TOOL, RESPIRABLE, Respiration, respiratory, Respiratory Diseases, respiratory INFECTION, Tool, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, VPXXXX, WAXXXX, WBXXXX, WCXXXX, WGXXXX, WIXXXX, WMXXXX, XDXXXX, XHXXXX, XIXXXX, XJXXXX, YCXXXX, YEXXXX, YFXXXX
Category(s): Collaboration Sought > Licensing, Application > Software / Apps, Application > Medical Devices, Application > Diagnostics, TherapeuticArea > Pulmonology, TherapeuticArea > Immunology, Application > Research Materials, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Non-Medical Devices, TherapeuticArea > Ophthalmology, Application > Vaccines, Application > Therapeutics, Application > Occupational Safety and Health, TherapeuticArea > Infectious Disease, Application > Consumer Products, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, ResearchProducts > Computational models/software, TherapeuticArea > Oncology
Defensin-Based Therapeutics for the Treatment of Pulmonary Disease
Investigators at the National Heart, Lung and Blood Institute have developed modified defensins that are resistant to degradation, have improved characteristics compared to unmodified defensins, and are promising candidates for pulmonary disease therapeutics. Defensins are small cationic peptides that defend the lung against pathogenic microorganisms...
Published: 10/28/2024   |   Inventor(s): Joel Moss
Keywords(s): ADP-ribose, ADP-ribose-arginine, ADP-RIBOSYLARGININE, ADP-ribosylation, AIRWAY, Arginines, ASTHMA, BBXXXX, cytotoxic, CYTOTOXICITY, DBXXXX, defensin, Defensins, DXXXXX, HNP-1, human neutrophil peptide 1, IB4XXX, IBXXXX, Inflammation, IXXXXX, neutrophil, Patent Category - Biotechnology, Pulmonary, PULMONARY FIBROSIS
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Pulmonology, Application > Diagnostics, Application > Research Materials
A Gene Knockout Mouse Model to Study Lung Disease and a Lung Disease Drug Target
Our researchers have created a gene knockout mouse model that lacks the cytochrome c oxidase subunit IV-2 in order to study the gene’s effects on controlling asthma. Background & Unmeet Need: Asthma is an inflammatory disease of the airways that affects 155 million people of all ages worldwide. Cytochome c oxidase (CcO) is a multi-subunit...
Published: 12/17/2024   |   Inventor(s): Maik Huettemann, Lawrence Grossman, David Bassett
Keywords(s): Asthma, Disease, Drug Target, Gene, Knock-out, Lung, Mouse Model
Category(s): Animal models, Biological materials, Life Science, Research tools, Protein/peptides
“Sweet-P”: Molecule for Targeting Human Glucocorticoid Receptor Beta in Asthma and Cancer
Project ID: D2016-49Background:Despite many breakthrough innovations occurring in the $14 billion Asthma market, numerous people are still affected by fatal asthma, and the United States contains the largest population affected by severe asthma. Glucocorticoids (GCs) are the most effective and commonly prescribed anti-inflammatory agents in treating...
Published: 5/9/2024   |   Inventor(s): Terry Hinds, Lucien McBeth
Keywords(s): Asthma, Bladder Cancer, Glucocorticoid (GC), Glucocorticoid Receptor α (GRα), Glucocorticoid Receptor β (GRβ), Leukemia, Peptide Nucleic Acid (PNA), Prostate Cancer, Sweet P
Category(s): Oncology, Inflammation & Immunity
Novel Synthetic Lung Surfactant Peptides
A novel synthetic lung surfactant for the treatment of neonatal and acute respiratory distress syndromes.Problem Solved by the TechnologyLung surfactant replacement therapy is commonly used on premature infants with neonatal respiratory distress syndrome (NRDS). NRDS, caused by a lack of surfactant, occurs in 10% of premature babies (1% of all newborns)...
Published: 5/7/2024   |   Inventor(s): Robert Notter, Alan Waring, Zhengdong Wang, Adrian Schwan, Larry Gordon, Frans Walther
Keywords(s): Asthma, Peptide, Pulmonary
Category(s): Therapeutic