Search Results - immunology+and+inflammation+treatments

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MVA and DNA Based SARS-CoV-2 Vaccines
Application Modified Vaccinia virus Ankara (MVA)- and deoxyribonucleic acid (DNA)-based vaccine for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Key Benefits Safety profile is known. Demonstrated antiviral activity against related Coronaviruses. Single dose of vaccination was shown to be effective against related Coronaviruses...
Published: 2/13/2025   |   Inventor(s): Rama Rao Amara, Sailaja Gangadhara
Keywords(s): Biologics, COVID19, DNA and RNA Vaccines, Immunology and Inflammation Treatments, Microbiology and Infectious Disease Treatments
Category(s): TechPub Algolia > Vaccines
Vaccine-pulsed Dendritic Cells as a Treatment for Aggressive Breast Cancers
Application Immunotherapy for HER2+ and triple-negative breast cancer. Key Benefits Autologous vaccine comprising patient-specific tumor antigens and immune stimulatory components against aggressive breast cancers. Prepared outside of the body and then administered to patients. Preclinical data indicate treatment decreases tumor growth and improves...
Published: 2/13/2025   |   Inventor(s): Periasamy (Selva) Selvaraj, Luis Munoz, Ramireddy Bommireddy, Christopher Pack, Shaker Reddy, Sampath Ramachandiran
Keywords(s): Immunology and Inflammation Treatments, Oncology Treatments, Women's Health
Category(s): TechPub Algolia > Therapeutics
Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System
Application Protein-based therapeutics for the treatment of IgG-mediated diseases. Key Benefits A new class of endoglycosidases for the treatment of IgG-mediated diseases. Four novel compounds have been developed that exhibited robust in vitro activity. Potential to become first-in-class medications for dysregulation of the adaptive immune system,...
Published: 2/13/2025   |   Inventor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos
Keywords(s): Enzyme and Protein Research, Immunology and Inflammation Treatments, Metabolic Disease Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
Vital Sign Trajectory Algorithm
Application A precision medicine algorithm that reduces mortality in sepsis patients by individualizing and targeting specific therapies to specific patients. Key Benefits An algorithm that uses bedside routine vital signs to optimize the precision treatment of sepsis. Clinical data show the ability of the algorithm to identify a subset of patients...
Published: 2/13/2025   |   Inventor(s): Sivasubramanium (Siva) Bhavani
Keywords(s): Algorithm, AI, and Machine Learning, Immunology and Inflammation Treatments
Category(s): TechPub Algolia > Software
Improving Pediatric Asthma Management for Urban Families
Application Home-based family psychoeducational intervention for low-income children with persistent asthma. Key Benefits Medical and psychosocial needs of patients and family members can be addressed simultaneously. Significantly improved asthma management and caregiver stress in randomized controlled clinical trial. Market Summary Asthma...
Published: 2/13/2025   |   Inventor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
Keywords(s): Healthcare Professional Education and Training, Immunology and Inflammation Treatments, Pediatrics, Respiratory Treatments
Category(s): TechPub Algolia > Therapeutics
Methods for Enhancing MSC Therapeutic Potential for Treatment of Osteoarthritis by Measuring and Targeting Intracellular Pathways
Application Highly transformative new strategy to enhance mesenchymal stromal cell consistency and efficacy for taking MSC therapies to clinical stage. Key Benefits Currently there is no method to determine if an MSC donor line will be therapeutically effective. Provides a point of use assay in the clinical setting which can determine MSC efficacy...
Published: 2/13/2025   |   Inventor(s): Nick Willett, Levi Wood, Jay McKinney
Keywords(s): Cell Therapy, Immunology and Inflammation Treatments
Category(s): TechPub Algolia > Research Tools, TechPub Algolia > Therapeutics
KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations, is...
Published: 2/13/2025   |   Inventor(s): Haian Fu, Cong Tang, Xiulei Mo
Keywords(s): Drug Target Identification, Enzyme and Protein Research, Immunology and Inflammation Treatments, Oncology Treatments
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Interleukin-37 to Enhance Effectiveness of CAR T-cell Therapy
­ Application IL-37-expressing CAR T-cells to treat B-cell acute lymphoblastic leukemia. Key Benefits Boosts the function of aged T-cells. Enhances the effectiveness of CAR T-cell therapy. Therapeutic potential to overcome aging-associated immune-senescence. Potent suppressor of chronic inflammation or pro-inflammatory cytokines. Market...
Published: 2/13/2025   |   Inventor(s): Curtis Henry, Sunil Raikar, Sarwish Rafiq
Keywords(s): Cell Therapy, Immunology and Inflammation Treatments, Oncology Treatments
Category(s): TechPub Algolia > Therapeutics
HIV-1 Clade C Protein Immunogen as HIV-1 Vaccine
Application Novel stabilized HIV-1 Clade C gp140 trimeric immunogen useful as a vaccine. Key Benefits Vaccine for HIV-1 infections. Induces both neutralizing and V1V2 scaffold directed antibody responses. V1V2 scaffold directed antibodies bind to multiple strains of HIV-1 from different clades including Clades B and C. Market Summary HIV-1...
Published: 2/13/2025   |   Inventor(s): Rama Rao Amara, Sailaja Gangadhara, Tiffany Styles, Anusmita Sahoo
Keywords(s): Immunology and Inflammation Treatments, Microbiology and Infectious Disease Treatments, Therapeutic Vaccines
Category(s): TechPub Algolia > Vaccines
Boosting Immunogenicity of Vaccines Using Saponins and Agonists of the Intracellular STING Pathway
Application Vaccine formulation of an activator of the stimulator of interferon genes (STING) pathway and saponin adjuvant for enhanced protection of aged population. Key Benefits Significantly improved protective immunity of vaccine in the aged. More efficient than the current methods of influenza vaccination of population 65 years of age or...
Published: 2/13/2025   |   Inventor(s): Elena Vassilieva, Richard Compans
Keywords(s): Immunology and Inflammation Treatments, Microbiology and Infectious Disease Treatments, Small Molecule, Vaccine Adjuvants
Category(s): TechPub Algolia > Vaccines
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