Search Results - respiratory

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Smartphone Diagnostic for Rapid Respiratory Virus Detection
Application Diagnostic and automatic surveillance platform to identify RSV, Influenza A, and COVID-19 in real-time. Key Benefits Rapid smartphone-based detection of multiple respiratory viruses in nasal swab, breath condensate, and saliva. Requires few reagents and no expensive equipment. Limit of detection on par with PCR and rapid readout. Enables...
Published: 8/22/2024   |   Inventor(s): Selma Piranej, Khalid Salaita
Keywords(s): COVID19, Microbiology/Infectious Diseases, Platform, Respiratory
Category(s): TechPub Algolia > Diagnostics
RSV Vaccine for Infants and Children
Application Vaccine for Respiratory Syncytial Virus (RSV) in infants and children. Key Benefits A novel vaccine targeting both the F and G proteins of the respiratory syncytial virus (RSV), including its variants. Preliminary data in in mice show the vaccine induced the production of antibodies associated with preventing disease. Potential to...
Published: 7/30/2024   |   Inventor(s): Larry Anderson, Binh Ha, Heying Sun
Keywords(s): Microbiology/Infectious Diseases, Pediatrics, Respiratory
Category(s): TechPub Algolia > Vaccines
A Preclinical Model for Mutant Human EGFR-driven Lung Adenocarcinoma
Abstract: Previously described epidermal growth factor receptor- (EGFR) driven tumor mouse models develop diffuse tumors, which are dissimilar to human lung tumor morphology and difficult to measure by CT and MRI scans. Scientists at the National Cancer Institute (NCI) have developed and characterized a genetically engineered mouse (GEM) model of human...
Published: 4/8/2024   |   Inventor(s): Simone Difilippantonio, Lionel Feigenbaum, Deborah Householder, Philip Martin, Zoe Ohler, Terry Van Dyke
Keywords(s): EGFR, Epidermal Growth Factor Receptor, GEM, Genetically Engineered Mouse, Lung adenocarcinoma, lung cancer, mouse model, Ohler Weaver, respiratory
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Repurposing an FDA-Approved Drug for Treating Age-Associated Lung Fibrosis
Application New use of an FDA-approved therapeutic, diroximel fumarate (Vumerity), for treating Idiopathic Pulmonary Fibrosis. Key Benefits Novel use of an FDA-approved drug, diroximel fumarate - DRF (Vumerity), for treating age-dependent lung fibrosis. Lung-targeted inhaled delivery of DRF is effective for boosting lung antioxidant responses...
Published: 8/22/2024   |   Inventor(s): Louise Hecker, Kosuke Kato
Keywords(s): Repurposed Drug, Respiratory
Category(s): TechPub Algolia > Therapeutics
LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS
LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS Researchers at UCSF, CZ Biohub SF, CZI and University of Colorado have developed a host/pathogen classifier to differentiate patients with lower respiratory tract infections (LRTI) from those with non-infectious acute respiratory illnesses. Lower respiratory tract infections (LRTI) are a leading cause...
Published: 5/18/2023   |   Inventor(s): Charles (Chaz) Langelier, Peter Mourani, John Kamm, Eran Mick, Alexandra Tsitsiklis, Katrina Kalantar, Lilliam Ambroggio, Joseph DeRisi
Keywords(s): Disease Classifier, Pathogen, Respiratory
Category(s): Technology Classifications > Biology
Therapeutic to Treat Age-Dependent Idiopathic Pulmonary Fibrosis
Application Therapeutic for treating age-associated lung fibrosis. Key Benefits Tecfidera (dimethyl fumarate - DMF) is an FDA approved therapy to treat multiple sclerosis via oral administration. A novel formulation for inhaled delivery demonstrated efficacy for a new indication: Idiopathic Pulmonary Fibrosis (IPF), where it promotes the reversal...
Published: 8/22/2024   |   Inventor(s): Louise Hecker, Kosuke Kato, Priyadarshini Muralidharan, Heidi Mansour
Keywords(s): Repurposed Drug, Respiratory
Category(s): TechPub Algolia > Therapeutics
Small Molecules for Treating Cystic Fibrosis
ApplicationSmall molecule compounds to potentiate most common type of CFTR mutation in cystic fibrosis patients.Key BenefitsPotentiates ΔF508-hCFTR mutation, addressing more than 60 percent of CF patients. Market SummaryCystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and ion channel that malfunctions in the genetic...
Published: 7/30/2024   |   Inventor(s): Nael McCarty, Guiying Cui, Hanoch Senderowitz, Netaly Khazanov
Keywords(s): Rare/Orphan Diseases, Respiratory, Small Molecule
Category(s): TechPub Algolia > Therapeutics, TechPub Algolia > Drug Discovery
Improving Pediatric Asthma Management for Urban Families
Application Home-based family psychoeducational intervention for low-income children with persistent asthma. Key Benefits Medical and psychosocial needs of patients and family members can be addressed simultaneously. Significantly improved asthma management and caregiver stress in randomized controlled clinical trial. Market Summary Asthma...
Published: 7/30/2024   |   Inventor(s): Marianne Celano, Lisa Kobrynski, Chanda Holsey
Keywords(s): Education & Training, Immunology/Inflammation, Respiratory
Category(s): TechPub Algolia > Therapeutics
Mononegavirales Vectors Expressing Chimeric Antigens
Human respiratory syncytial virus (RSV) continues to be the leading viral cause of severe acute lower respiratory tract disease in infants and children worldwide, and also is an important cause of morbidity and mortality in the elderly. A licensed vaccine or antiviral drug suitable for routine use remains unavailable. This invention relates to the use...
Published: 7/25/2024   |   Inventor(s): Linda Brock, Ursula Buchholz, Peter Collins, Shirin Munir
Keywords(s): Added, Attenuated, DA4BXX, DA4XXX, DC5BXX, DC5XXX, DCXXXX, DD1XXX, DDXXXX, DEXXXX, DXXXXX, Expressing, F, Fusion, Gene, Highly, Human, Immunogenic, Macaques, MPV, Murine, PNEUMONIA, Protein, respiratory, RHESUS, RSV, Syncytial, virus
Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
Recombinant Chimeric Bovine/Human Parainfluenza Virus 3 Expressing SARS-CoV-2 Spike Protein and Its Use
Vaccines for SARS-CoV-2 are increasingly available under emergency use authorizations; however, indications are currently limited to individuals twelve (12) years or older. They also involve intramuscular immunization, which does not directly stimulate local immunity in the respiratory tract, the primary site of SARS-CoV-2 infection, shedding and spread....
Published: 7/25/2024   |   Inventor(s): Shirin Munir, Cindy Luongo, Peter Collins, Cyril Le Nouen, Xueqiao Liu, Ursula Buchholz
Keywords(s): 2, ACUTE, Attenuated, B/HPIV3, BOVINE/HUMAN, chimeric, CORONAVIRUS, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DEXXXX, DXXXXX, Expression, GLYCOPROTEIN, PIV3, respiratory, S, SARS-CoV-2, SEVERE, spike, Syndrome
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Research Materials
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