Search Results - cell+lines+and+organoids

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Repurposing a Potent MDM2 Inhibitor for Leukemia Treatment
Application VERU-111, also known as sabizabulin, is a potent microtubule inhibitor and, notably, an MDM2 inhibitor. This repurposed compound demonstrates remarkable efficacy in the treatment of Acute Myeloid Leukemia (AML). Key Benefits Unique dual-action functionality as a microtubule and MDM2 inhibitor. Successful inhibition of MDM2, an oncogene...
Published: 2/13/2025   |   Inventor(s): Deborah DeRyckere, Muxiang Zhou, Lu Bing Gu, Douglas Graham, Tao Liu
Keywords(s): Cell Lines and Organoids, Hematology and Blood Products, Oncology Treatments, Repurposed Drug
Category(s): TechPub Algolia > Drug Discovery
Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease. Key Benefits An immortalized caspase-3-deficient MEF cell line. Tool to study protease induced apoptosis. Technical Summary Emory inventors have discriminated a previously unknown role...
Published: 2/13/2025   |   Inventor(s): Lawrence Boise, Katelyn Ponder
Keywords(s): Cell Lines and Organoids, Enzyme and Protein Research
Category(s): TechPub Algolia > Research Tools
HIF/Hypoxia-Reporter Cell Lines
Application Hypoxia/Hypoxia-inducible factor 1 (HIF-1) inducible luciferase/LacZ reporter cell lines. Key Benefit Expression of luciferase and beta-galactosidase in response to hypoxia treatment. Technical Summary Emory University researcher, Erwin Van Meir, has made HIF/hypoxia reporter cell lines by stably transfecting the cells with pBIGL-V6R-HRE-Luc/LacZ...
Published: 2/13/2025   |   Inventor(s): Erwin Van Meir
Keywords(s): Cell Lines and Organoids, Oncology Treatments
Category(s): TechPub Algolia > Research Tools
ADGRB3/BAI3-Expressing Cell Lines
ApplicationADGRB3/BAI3 expressing human brain tumor cell lines.Technical SummaryAdhesion G protein coupled receptor B3 (ADGRB3), also called Brain-specific angiogenesis inhibitor 3 (BAI3) is a protein that in humans is encoded by the ADGRB3 gene. Emory University researcher Erwin Van Meir has developed medulloblastoma cell lines DAOY, UW288-1 and PFSK1,...
Published: 2/13/2025   |   Inventor(s): Erwin Van Meir
Keywords(s): Cell Lines and Organoids, Neurology and Pain Treatments, Oncology Treatments
Category(s): TechPub Algolia > Research Tools
Spatiotemporal Genomic Analysis to Identify and Extract Rare Cancer Cells
Application Isolation and analysis of phenotype and genome of rare cell types within a tumor for research and potential diagnostics. Key Benefits Allows the identification of a single cell or group of cells within a tumor sample using phenotypic criteria. Enables both phenotypic and genetic analysis of the same rare cells within a tumor. Market...
Published: 2/13/2025   |   Inventor(s): Adam Marcus, Jessica Konen
Keywords(s): Cell Lines and Organoids, Oncology Treatments, Platform
Category(s): TechPub Algolia > Diagnostics, TechPub Algolia > Research Tools
Immortalized Mouse Aortic Endothelial Cell Lines
Application Immortalized (using polyoma middle T-antigen) mouse aortic endothelial primary cell lines for studying vascular biology and pathophysiology, including cardiovascular research. Key Benefits Immortalized from mouse artery endothelial cells using polyoma middle T-antigen. Validated retention of primary endothelial markers and structural...
Published: 2/13/2025   |   Inventor(s): Hanjoong Jo, Chih-Wen Ni, Sandeep Kumar
Keywords(s): Cardiology and Vascular Devices, Cell Lines and Organoids
Category(s): TechPub Algolia > Research Tools
Chemically Induced Pluripotent Stem (CiPS) Cells
Application Generation of pluripotent stem cells from adult somatic cells for medical use. Key Benefits No exogenous genetic manipulations, which minimize oncogenic effects, were observed in current methods. Peripheral blood can be used as a source of parent cell instead of fibroblasts or keratinocytes. Market Summary The economic and psychological...
Published: 2/13/2025   |   Inventor(s): Young-Sup Yoon, Ji Woong (Jay) Han, Xiaodong Cheng, Antonello Mai
Keywords(s): Cell Lines and Organoids, Cell Therapy
Category(s): TechPub Algolia > Therapeutics
A Cellular Model for Huntington's Disease
Applications Diagnosis and treatment of Huntington's disease. Technical Summary Huntington's disease (HD) is a genetically inherited disease that leads to progressive neurodegeneration, resulting in motor disturbances, loss of memory and cognition, and psychiatric manifestations. The underlying molecular and biochemical basis of HD are not...
Published: 2/13/2025   |   Inventor(s): Xiao-Jiang Li, Shi Hua (Shihua) Li
Keywords(s): Cell Lines and Organoids, Neurology and Pain Treatments
Category(s): TechPub Algolia > Research Tools