Search Results - targeted

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Hspa2 Knockout Mice for Study of Spermatogenesis and Male Infertility
HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Researchers discovered that HSPA2 protein is expressed in spermatogenesis during the meiotic phase. Spermatogenic cells lacking the HSPA2 protein arrest in mid-meiosis and undergo apoptosis. HSPA2 is present in the synaptonemal complex of wild-type mice...
Published: 10/28/2024   |   Inventor(s): Edward Eddy
Keywords(s): Deletion, Gene, Generation, Hsp70-2, Hspa2, IDXXXX, IXXXXX, KNOWN, Mouse, previously, Spermatogenesis, Strain, Targeted
Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Therapeutics, Application > Research Materials
Platform Technology Using Ubiquitin to Improve the Delivery and Efficacy of Cytosolic Targeted Toxins
Targeted toxins (TT) are hybrid protein drugs consisting of ligands that bind to the surface of cancer cells and deliver polypeptide toxins that kill malignant cells by inactivating cytosolic protein synthesis and inducing cell death. A major challenge in the construction of targeted toxins is reducing the nonspecific binding of the toxin moiety to...
Published: 8/15/2024   |   Inventor(s): Stephen Leppla, Shihui Liu, Thomas Morley, Christopher Bachran
Keywords(s): ACTING, CBXXXX, CXXXXX, Cytosolic, EFFICACY, FUSIONS, IMPROVING, Targeted, TOXINS, Ubiquitin
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
A Mouse with a Targeted Mutation in the Uncoupling Protein-3 (upc3) Gene
The NIH announces the development of a transgenic mouse with a targeted mutation in the ucp3 gene. The ucp3 gene is implicated I the function of regulating energy metabolism. This regulatory function is thought to be accomplished by changing metabolic efficiency (causing energy expended as heat rather than used for ADP/ATP conversion) and/or by participating...
Published: 4/8/2024   |   Inventor(s):  
Keywords(s): AC5XXX, ACXXXX, Animal Model, AXXXXX, BAXXXX, Gene, Mouse, MUTATION, Protein-3, Q fever, Targeted, UCP3, Uncoupling
Category(s): Collaboration Sought > Licensing, ResearchProducts > Animal Models