Search Results - small+molecules

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Identification of Small Molecules as Novel Adipogenic Enhancers for Edible Adipose Tissues (Case No. 2024-125)

Summary: UCLA researchers in the Department of Integrative Biology & Physiology have developed a novel small molecule-based approach for enhancing lipid accumulation and adipogenesis in edible adipose tissues for cultured meat production. Background: With the global population expanding rapidly, there is an urgent demand for sustainable protein...

Published: 7/23/2026 | Updated: 7/23/2026 | Inventor(s): Amy Rowat, Robert Damoiseaux, Qingwen Xie

Keywords(s): 3D biofabrication, Agbio, Agriculture, Biomaterial, Cell and tissue culture, Cell Culture, Cell Growth, cell proliferation, cell-extracellular matrix (ECM), cellular aggregates, Cellular agriculture, Cellular Differentiation, Confocal Microscopy, Cultured meat, fat quantification, fatty acids, High-Content Screening, High-Throughput Screening, Industrial applications: food processing, fermentation, lipidomics, meat, meat production, nutrition, scaffolds, Screening Libraries, Small molecule screening, small molecules, subcutaneous adipose tissue, Sustainable nutrition, Tissue Engineering

Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Screening Libraries, Life Science Research Tools > Cell Lines, Life Science Research Tools > Cell Counting And Imaging, Life Science Research Tools > Microscopy And Imaging, Therapeutics > Agtech And Animal Health, Chemical > Chemical Processing & Manufacturing, Materials > Functional Materials

Targeted Nanocarriers for Brain Inflammation and Cancer Cachexia

Nanocarriers deliver anti-inflammatory therapeutics across the blood-brain barrier to activated microglia Background Delivering therapeutics to the brain remains a major drug-development challenge because the blood-brain barrier restricts systemic agents from reaching therapeutically relevant concentrations in the central nervous system. This barrier...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s): Oleh Taratula, Olena Taratula, Yoon Tae Goo

Keywords(s): anti-inflammatory, Anti-inflammatory drugs, biodegradable, biodistribution, blood-brain barrier, brain delivery, brain inflammation, CNS drug delivery, cytokine expression, Drug Delivery, Drug Development, glutathione, immune cell, immunohistochemistry, irak4 inhibitor, lipopolysaccharides, microglia, mouse model, nanocarrier, nanocarriers, nanomedicine, neuroinflammation, pancreatic cancer, pharmaceuticals, pharmacokinetics, preservation, pro-inflammatory cytokine, small molecules, water-soluble, weight maintenance

Category(s): Therapeutics

ICA‑1S and ζ‑Stat: Selective aPKC Inhibitors for Anti‑Angiogenic Control Neuroblastoma

Advantages Upstream pathway control: Suppresses VEGF‑A by targeting aPKC, a master regulator of angiogenic signaling. Selective, small-molecule mechanism: offers lower immunogenicity and easier development than antibody-based therapies. Combination-therapy ready: upstream angiogenic pathway control enables synergy with existing treatments. Summary Neuroblastoma...

Published: 7/9/2026 | Updated: 2/16/2026 | Inventor(s): Sloan Breedy, Wishrawana Ratnayake, Mildred Acevedo-Duncan

Keywords(s): Cancer Treatment, Small Molecules

Category(s): Technology Classifications > Cancer, Technology Classifications > Chemistry, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

Spatiotemporal Drug Control in Autoimmune and Inflammatory Diseases: Photoswitchable JAK2 Inhibitors for Reversible Kinase Modulation

Advantages Precise spatiotemporal control and reversible modulation of kinase activity Reduced systemic toxicity and off-target effects Superior binding affinity and isomer selectivity than traditional Jak 2 inhibitor Summary Janus kinase 2 (JAK2), a key player in hematologic cancers and autoimmune diseases, is a particularly challenging target...

Published: 6/22/2026 | Updated: 8/18/2025 | Inventor(s): Shelby Kell, Chavdar Slavov

Keywords(s): Autoimmune Diseases, Inflammatory Diseases, Small Molecules, Therapeutics

Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals

Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates

Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...

Published: 7/8/2026 | Updated: 7/31/2025 | Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li

Keywords(s): Antiviral, Small molecules

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics

Novel Antibiotic Inhibiting Elongation Factor Complex in Gram-Positive Bacteria

Invention Summary: Antibiotic resistance remains a global health challenge with millions of related deaths each year. Gram-positive bacterial infections, like those caused by Staphylococcus aureus, are likely to acquire and develop resistance to clinically available antibiotics. Therefore, it is crucial to identify and develop novel antibiotics...

Published: 4/15/2026 | Updated: 6/5/2025 | Inventor(s): Wlodek Mandecki, Emanuel Goldman, Maxim Chudaev, Mark Henderson, Juan Marugan, Wenjuan Ye, Kenneth Wilson, Dane Parker

Keywords(s): Antibacterial, Small molecules

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics

Analoging and SAR-Based Chemical Approach to Improve the Therapeutic Potency of Small-Molecule Inhibitors of Metastasis (UCLA Case No. 2024-116)

UCLA researchers in the Department of Molecular and Medical Pharmacology have developed an analoging and SAR-based chemical approach to generate novel, safe, and effective small-molecule inhibitors for preventing and treating cancer metastasis. BACKGROUND: The limited understanding of the biological mechanisms underlying metastasis in clear cell renal...

Published: 7/20/2026 | Updated: 5/14/2025 | Inventor(s): Lily Wu, Moe Ishihara, Robert Damoiseaux, Stuart Conway

Keywords(s): Cancer, Metastasis, Oncology (Small Molecules, Peptides and Antibodies), Small molecule therapeutics, small molecules

Category(s): Therapeutics > Oncology

Enterovirus D68 capsid inhibitors as antivirals

Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...

Published: 7/8/2026 | Updated: 1/27/2025 | Inventor(s): Jun Wang, Yanmei Hu, Kan Li

Keywords(s): Antibacterial, Small molecules

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics

Small Molecule Humanin Mimetics and Enhancers That Normalize Neuronal p-AKT as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2023-230)

UCLA researchers in the Department of Neurology have discovered novel small molecule humanin mimetics for the treatment of Alzheimer's disease and other chronic conditions with dysregulated p-Akt. BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia accounting for 60-70% of all cases. Nearly 7 million Americans are living...

Published: 7/20/2026 | Updated: 7/22/2024 | Inventor(s): Varghese John

Keywords(s): Alzheimers disease, Cardiovascular, Cardiovascular Disease, Dementia, diabetes, mimetics, pAKT signaling, small molecules

Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular

Investigating the Role of BIN1's SH3 Domain in Alzheimer's Desease

Advantages: The approach of targeting BIN1, a gene associated with AD increases the likelihood of finding effective therapeutic interventions. Determining the crystal structure of BIN1's SH3 domain provides detailed structural information which is crucial for designing small molecule inhibitors. The research reports promising preliminary...

Published: 6/22/2026 | Updated: 9/28/2023 | Inventor(s): Gopal Thinakaran

Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience, Small Molecules

Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics

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