Search Results - small+molecules

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Inhibitors of the N-terminal Domain of the Androgen Receptor (UCLA Case No. 2023-075)
Researchers at UCLA under the guidance of Drs. Matthew Rettig and Michael Jung have developed novel molecular compounds that reduce growth of prostate cancer cells. Dr. Jung in collaboration with Dr. Rettig have furthered the development of these compounds by synthesizing a new series of analogues that have similar inhibitory effects. BACKGROUND: Prostate...
Published: 9/23/2024   |   Inventor(s): Matthew Rettig, Michael Jung
Keywords(s): androgen receptor therapy, castration resistant prostate cancer, Oncology, Oncology (Small Molecules, Peptides and Antibodies), prostate cancer, small molecules
Category(s): Therapeutics > Oncology, Therapeutics > Oncology > Oncology (Small Molecules)
Small Molecule Humanin Mimetics and Enhancers That Normalize Neuronal p-AKT as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2023-230)
UCLA researchers in the Department of Neurology have discovered novel small molecule humanin mimetics for the treatment of Alzheimer's disease and other chronic conditions with dysregulated p-Akt. BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia accounting for 60-70% of all cases. Nearly 7 million Americans are living...
Published: 7/22/2024   |   Inventor(s): Varghese John
Keywords(s): Alzheimers disease, Cardiovascular, Cardiovascular Disease, Dementia, diabetes, mimetics, pAKT signaling, small molecules
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular
Investigating the Role of BIN1's SH3 Domain in Alzheimer's Desease
­Advantages: The approach of targeting BIN1, a gene associated with AD increases the likelihood of finding effective therapeutic interventions. Determining the crystal structure of BIN1's SH3 domain provides detailed structural information which is crucial for designing small molecule inhibitors. The research reports promising preliminary...
Published: 1/23/2024   |   Inventor(s): Gopal Thinakaran
Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience, Small Molecules
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics
A treatment to promote skin wound healing
Treatment of wounds with TGM shows improved recovery compared to control group in a span of 10 days. Invention Summary: Helminths are potent modulators of immune function capable of stimulating an immune response that includes significant wound healing effector functions. Effective wound repair requires both the direct reconstruction...
Published: 7/26/2024   |   Inventor(s): William Gause, Fei Chen, Zhugong Liu, Pankaj Mishra
Keywords(s): Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 8/20/2024   |   Inventor(s): Jun Wang, Edward Arnold, Francesc Ruiz Figueras, Prakash Jadhav, Bin Tan, Ahmadullah Ansari, Ashima Chopra
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
Use of Retinoids in Congenital Erythropoietic Porphyria
Invention Summary: Congenital erythropoietic porphyria (CEP) is an unaddressed orphan disease caused by a rare genetic disorder leading to accumulation of uro/coproporphyrin-I (uro-I) in tissues due to inhibition of the enzyme uroporphyrinogen-III synthase. Clinical manifestations of CEP include bone fragility, severe photosensitivity, and photo-mutilation....
Published: 8/28/2024   |   Inventor(s): Bishr Omary, Jordan Shavit
Keywords(s): Small molecules
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
Combined Opioidergic and Beta-Adrenergic Drugs for Cancer and Immune Diseases
­​ Figure 1. (Left) Combined, synergistic treatment with naltrexone (NTX), propranolol (PRO), and Anti-PD1 antibody shows decrease in tumor size, by volume. (Right) Combined treatment of NTX, DPDPE, and PRO similarly decreases tumor size compared to controls. Invention Summary: One of the major cancer therapy approaches that is being...
Published: 5/8/2024   |   Inventor(s): Dipak Sarkar
Keywords(s): Anti-cancer, Small molecules
Category(s): Technology Classifications > Cancer, Technology Classifications > Healthcare & Life Sciences
Novel Selective Anti-chlamydial Compounds and Use
ze: 12px;color: #4F81BD;line-height: 1;border-collapse: collapse; } A set of photographs showing inhibition of C. trachomatis by acylpyrazoline (Using compound 4) Invention Summary: Chlamydia trachomatis is the most common sexually transmitted pathogenic bacterium worldwide. If left untreated...
Published: 1/31/2024   |   Inventor(s): Huizhou Fan, Jacques Roberge
Keywords(s): Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Sigma-1 Receptor Antagonists – Non-Addictive Pain Management
Invention Summary: The sigma 1 receptor (S1R), a molecular chaperone protein located in the endoplasmic reticulum and plasma membranes, plays important roles in various pathological disorders including pain. The potential commercial applications of novel S1R antagonists are twofold: 1) as stand-alone therapy for the treatment of chronic neuropathic...
Published: 5/1/2024   |   Inventor(s): William Welsh, Youyi Peng
Keywords(s): Antiviral, Neurological disorder & neuropathic pain, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Novel Inhibitors of Keap1-Nrf2 Protein-Protein Interaction
Novel Small Molecule Direct Inhibitors of Keap1-Nrf2 Protein-Protein Interaction Invention Summary: Nrf2 is a key transcription factor mediating anti-inflammatory and antioxidant responses in the body. Keap1 is a well-known repressor of Nrf2 that targets Nrf2 for its rapid proteasomal degradation. Dysfunctional Keap1-Nrf2 axis contributes to...
Published: 5/15/2024   |   Inventor(s): Longqin Hu, Dhulfiqar Abed
Keywords(s): Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
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