Search Results - blood-brain+barrier

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Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)
Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...
Published: 7/11/2024   |   Inventor(s): Michael Jung, Frank Pajonk
Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity
Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine
Development of Novel Compounds to Suppress Neuronal Stress and Cross the Blood Brain Barrier (UCLA Case No. 2021-165)
SUMMARY: An interdisciplinary group of UCLA researchers have developed and validated a library of compounds that alleviate symptoms of Rett Syndrome and hold enormous therapeutic potential for the long-term treatment of other intellectual disability syndromes. BACKGROUND: Intellectual disability (ID) affects more than 100 million people globally and...
Published: 5/8/2024   |   Inventor(s): William Lowry, Michael Jung, Xiaoguang Liu, Elena Korsakova
Keywords(s): blood-brain barrier, Drug, intellectual disability, Organoids, senescence
Category(s): Therapeutics > CNS and Neurology, Life Science Research Tools, Diagnostic Markers > Targets And Assays
Intelligent Stent System for Chronic On-Demand Drug Delivery (Case No. 2021-069)
Summary: UCLA researchers in the Department of Neurology have developed an intelligent stent system for chronic on-demand drug delivery, addressing the challenge of the blood-brain barrier hindering drug therapy in the central nervous system. Background: The blood-brain barrier poses a significant obstacle to effective drug delivery to the central...
Published: 7/9/2024   |   Inventor(s): Jose Morales, Haotian Lu, Huachen Cui, Xiaoyu (Rayne) Zheng
Keywords(s): blood flow management, blood-brain barrier, Drug, Drug Delivery, Drug monitoring, Invasiveness Of Surgical Procedures, MEMS, minimally invasive device, minimally invasive drug delivery systems, neural signals, neural stimulation, Neurocognitive, Neurodegeneration, neurological disorders, Neurology, neuro-oncology, Neuropathology, Neurosurgery, non-invasive, non-invasive drug monitoring, on-demand drug delivery, Pharmaceutical Drug, piezoelectric ultrasound transducers
Category(s): Platforms, Platforms > Drug Delivery, Medical Devices, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Oncology, Therapeutics > Musculoskeletal Disease
Size-dependent brain distribution of macromolecular drug delivery platform
Abstract: The blood brain barrier (BBB) is a specialized endothelium that prevents the uptake of substances from the systemic circulation into the central nervous system. This barrier, while protecting the sensitive physiological environment of the brain, is also a major impediment in administering therapeutics that need to pass through the BBB. A drug...
Published: 4/8/2024   |   Inventor(s): Stephan Stern, David Stevens
Keywords(s): BBB, Blood-brain Barrier, Brain Cancer, Controlled Drug Release, Drug Delivery Platform, Neurological Disorders, Stern
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology
Receptor-Ligand Combination for Specific Drug Delivery to the Brain
Molecule Crosses the Blood-Cerebrospinal Fluid Barrier to Deliver Therapy into Targeted CellsThis engineered receptor-ligand combination targets and crosses the brain barriers of mammals to deliver drugs and therapeutics to the brain. About 12 percent of all deaths worldwide are caused by neurological disorders such as Alzheimer’s, Parkinson’s...
Published: 12/20/2021   |   Inventor(s): Hector Mendez-Gomez, Nicholas Muzyczka
Keywords(s): Blood-brain barrier, brain delivery, brain-specific drug delivery, Gene Therapy, receptor-mediated transcytosis
Category(s): Technology Classifications > Human Health Care > Drug Delivery, Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Research Tools > Therapeutics
Use of fluorescent ANTS to examine the BBB-permeability of polysaccharide
Project ID: D2015-27Invention Description: Methods of generating and administering digestion products of FDA-approved low acyl gellan gum (LA-GAGR) to produce neuroprotective mega-GAGR, midi-GAGR, and mini-GAGR and administration thereof.Applications: Compositions comprising midi and/or mini-GAGR have been shown to be useful for treatment of neurodegenerative...
Published: 8/3/2022   |   Inventor(s): Joshua Park, Kevin Christopher, Vishruti Makani
Keywords(s): ALS, Alzheimer’s disease, Blood-brain Barrier, Brain Trauma, Neuritogenesis, Neurodegenerative, Neuroprotective, Spinal Cord Injury
Category(s):  
Novel agents and methods for treating neurodegenerative disorders
Project ID: D2013-69 IP Status: Issued Patents 10,792,301 B2, 11,197,885 B2 Invention Description: Methods of generating and administering digestion products of FDA-approved low acyl gellan gum (LA-GAGR) to produce neuroprotective mega-GAGR, midi-GAGR, and mini-GAGR and administration thereof. Applications: Compositions comprising midi and/or mini-GAGR...
Published: 10/4/2024   |   Inventor(s): Joshua Park, Dong Shik Kim, Kenneth Hensley
Keywords(s): ALS, Alzheimer’s disease, Blood-brain Barrier, Brain Trauma, Neuritogenesis, Neurodegenerative, Neuroprotective, Spinal, Spinal Cord Injury
Category(s): Neuroscience