Search Results - mildred+acevedo-duncan

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Novel Potential Treatment for Glioblastoma Multiforme (GBM) via Potent Inhibitor of Atypical Protein Kinase C-iota
Advantages: ICA-1S uniquely inhibits aPKC-ι and Connexin 43, critical proteins in Glioblastoma Multiforme progression Significantly reduces glioblastoma cell proliferation, demonstrating superior efficacy compared to current chemotherapy agents Overcome therapeutic resistance by targeting Connexin 43, enhancing responsiveness to treatment Addressing...
Published: 3/25/2025   |   Inventor(s): Mildred Acevedo-Duncan, Grazielly Teodoro
Keywords(s): Cancer Treatment
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Stavudine as a Potential Anticancer Agent for the Treatment of Pancreatic Cancer
Advantages: Repurposes an existing FDA-approved drug Achieves dose-dependent inhibition of ASPC-1 pancreatic cancer cell proliferation May enhance treatment efficacy when combined with standard chemotherapy Summary: Pancreatic cancer remains one of the most lethal malignancies due to late diagnosis, limited treatment efficacy, and a tumor microenvironment...
Published: 3/10/2025   |   Inventor(s): Sadia Noosrat Boshra, Mildred Acevedo-Duncan, Kirpal Bisht
Keywords(s): Cancer Treatment Pancreatic Cancer
Category(s): Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas, Technology Classifications > Medical > Oncology
Method for Treating Melanoma using an Inhibitor of an Atypical Protein Kinase C (PKC)
­Advantages: Effectively decreases melanoma cell proliferation and suppresses tumor migration and metastasis. Promotes cancer cell death, specifically targeting melanoma cells and sparing healthy melanocytes. The method not only treats melanoma by targeting atypical PKC isoforms but also utilizes PKC-ι and PKC-ζ levels as biomarkers...
Published: 8/16/2024   |   Inventor(s): Mildred Acevedo-Duncan, Wishrawana Ratnayake, David Ostrov
Keywords(s): Cancer Treatment Melanoma
Category(s): Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas, Technology Classifications > Medical > Therapeutics, Technology Classifications > Cancer
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan, Sloan Breedy, Aaron Todman, Luke Lajmi
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Cancer
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Mildred Acevedo-Duncan, Kirpal Bisht
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer, Technology Classifications > Medical > Pharmaceuticals
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer
A Method of Treating Colorectal Cancer Using Atypical Protein Kinase C Inhibitors
Competitive Advantages Reduces colorectal cancer cell growth and proliferation Does not harm healthy cells Applicable as anti-atypical PKC therapy Summary USF scientists have discovered that by inhibiting PKC-iota and PKC-zeta with certain drugs (ACPD, DNDA and ICA-1), a significant decrease in cancer cell proliferation is shown. Furthermore,...
Published: 6/14/2023   |   Inventor(s): Mildred Acevedo-Duncan, Anisul Islam, David Ostrov
Keywords(s):  
Category(s): Technology Classifications > Cancer