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Exogenous Acetate Formulations for Treating Alcohol Use Disorder and Withdrawal
Advantages Mechanistic Innovation: stabilizes brain energy metabolism and modulates adenosine signaling mechanisms not targeted by current addiction therapies. Targeted Brain Delivery: formulations enable effective acetate transport across the blood-brain barrier, (BBB) Controlled and sustained release Versatile Administration Routes: compatible...
Published: 9/30/2025   |   Inventor(s): Dominic D'Agostino
Keywords(s): Neuroscience, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics, Technology Classifications > Chemistry, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Neuroscience
Methionine Sulfoxide Reductase A (MsrA) Gene Therapy for Retinal Degeneration
Advantaages Targeted Protection Against Oxidative Stress Dual-Vector Delivery System (AAV and Lenti) Simple and scalable plasmid design for efficient production Suitable for major ophthalmology indications: Age-related macular degeneration (AMD), Retinitis pigmentosa, other oxidative stress-related retinal degenerations Summary Oxidative stress...
Published: 10/14/2025   |   Inventor(s): Manas Biswal
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Semicarbazones Synthesis Using Ethyl Lactate or Dimethyl Isosorbide as a Green Solvent
A novel method for synthesizing semicarbazones without toxic solvents that is both faster and produces higher yields. Background: Semicarbazones comprise an important structural class of compounds with valuable and diverse biological properties. They are used to synthesize various heterocyclic compounds, which have wide ranges of pharmacological activities...
Published: 10/24/2025   |   Inventor(s): Eric Helms, Jacqueline Bennett
Keywords(s): chemicals, environment, environmental chemistry, organic chemistry, pharmaceuticals, polymers, TAF
Category(s): Technology Classifications > Materials and Chemicals, Campus > SUNY Geneseo, Campus > SUNY Oneonta
Novel Combination Treatment for Glioblastoma
Advantages: Temozolomide (TMZ), Cannabidiol (CBD), and CCR6/CCL20 inhibitors work together to overcome Glioblastoma resistance and enhance efficacy Targeted CCL20/CCR6 inhibition blocks survival pathways in glioblastoma, reducing resistance and relapse while improving outcomes Enhances CD8+ T cells and rewires immunity, offering powerful, lasting...
Published: 4/30/2025   |   Inventor(s): Subhra Mohapatra, Shyam Mohapatra, Ryan Green, Karthick Mayilsamy
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Colorectal Cancer Gene Expression Signature as a Predictor for Therapy Outcomes
Advantages: Novel biomarker development: Unique 10-gene signatures distinguish the contributions of tumor epithelium (EPI) & tumor microenvironment (TME) in colorectal cancer (CRC) Clinical Relevance: EPIS signature predicts better progression-free survival in cetuximab-treated metastatic CRC patients; TMES correlates with worse survival outcomes Enhanced...
Published: 10/14/2025   |   Inventor(s): Timothy Yeatman, Mingli Yang
Keywords(s): Cancer Treatment, Pharmaceuticals
Category(s): Technology Classifications > Cancer, Technology Classifications > Medical, Technology Classifications > Chemistry
Anti-Thrombin Nanoparticles and Therapeutics to Treat Necrotizing Enterocolitis
Advantages: Bivalirudin-tagged nanoparticles bind and neutralize nascent thrombin in clots, minimizing systemic anticoagulant effects Anti-thrombin nanoparticle confines its anticoagulant activity to sites of clot formation, limiting excessive systemic coagulation inhibition Dual therapeutic and diagnostic potential allows clinicians to treat NEC...
Published: 2/5/2025   |   Inventor(s): Akhil Maheshwari, Samuel Wickline, Koppenruncholan Namachivayam, Hua Pan
Keywords(s): Gastrointestinal / Digestive Health, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals
4-Aminopyridine to Enhance Arousal
We anticipate that this topical treatment will increase genital sensitivity in women, facilitating sexual arousal and helping treat sexual dysfunction. Background: As the population ages, there has been increased focus around sexual dysfunction as a medical issue. This has resulted in a number of successful treatments that ameliorate sexual dysfunction...
Published: 5/13/2025   |   Inventor(s): Steven Rothman
Keywords(s): molecular pharmacology, multiple sclerosis, pharmaceuticals, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines
SLURP1 is a Novel Therapeutic Target for Ocular Surface Inflammatory Disorders
Advantages: Identification and validation of SLURP1 as a therapeutic target for treating ocular therapies SLURP1 enhances antioxidant defenses SLURP1 counteracts TGF-β-induced EMT in corneal epithelial cells Potential for Formulating eye care products with SLURP1 to mitigate oxidative stress and maintain corneal epithelial homeostasis (e.g....
Published: 10/14/2025   |   Inventor(s): Shivalingappa Swamynathan, Sudha Swamynathan, Satinder Kaur
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology
New Target for Heart Failure Therapies: Modifying MRPS5/ATF4 Signaling in Cardiomyocytes
Advantages: Identification of MRPS5 as a Therapeutic Target: Reduction of MRPS5 expression stimulates cardiomyocyte proliferation and enhances heart function Discovery of the MRPS5 signaling axis: Decreased MRPS5 enhances ATF4 and Knl1, which promote cardiomyocyte, boosting cardiac recovery after myocardial injury Improved Survival and Cardiac...
Published: 10/14/2025   |   Inventor(s): Da-Zhi Wang, John Mably
Keywords(s): Biotechnology, Cardiological Diseases Treatment, Cell & Tissue Culture & Engineering, Medical Diagnostics, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Pharmaceuticals
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