Search Results - pharmaceuticals

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Inhibitors of Transporters or Uptake of Monoaminergic Neurotransmitters
Background One form of medical treatment for depression and neuropathic pain features a dual inhibitor called Cymbalta. This drug is manufactured and marketed by Eli Lilly. Researchers at Oregon State University have discovered a very efficient way of synthesizing Synosutine, which is comparable to Cymbalta in limited in vitro and in vivo assay....
Published: 6/17/2024   |   Inventor(s): James White, David Chan, David Wong, Rajan Juniku, Jongtae Yang
Keywords(s): Biomedical, pharmaceuticals
Category(s): Chemistry
Regulated Delivery of Antibiotic and Antifungal Drugs Via Controlled Degradable Chondroitin Sulfate Particles
­Advantages: Novel synthesis of Chondroitin sulfate (CS) particles for encapsulation of antibiotic and antifungal drugs. Synthesis can be fine-tuned to produced non-degradable, slightly degradable, and completely degradable CS drug carriers, for a variety of therapeutic applications. CS particles were successfully tested for encapsulation...
Published: 5/14/2024   |   Inventor(s): NURETTIN SAHINER, Ramesh Ayyala
Keywords(s): Drug Delivery and Nanomedicine, Pharmaceuticals
Category(s): Technology Classifications > Medical > Cell & Tissue Engineering, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical
Biosynthetic Gene Cluster for the Peptide Antibiotic Enduracidin
Background The emerging and persistent threat of multidrug-resistant bacterial infections has resulted in enormous healthcare costs and poses major challenges to public health. To address the need for new antibiotics capable of combating the gowning problem of resistance, Oregon State University researchers cloned and patented the biosynthetic gene...
Published: 9/12/2024   |   Inventor(s): T. Zabriskie, Xihou 希厚 Yin 银
Keywords(s): Biomedical, Biotechnology, Medical Science & Technologies, pharmaceuticals
Category(s): Therapeutics
Semicarbazones Synthesis Using Ethyl Lactate or Dimethyl Isosorbide as a Green Solvent
A novel method for synthesizing semicarbazones without toxic solvents that is both faster and produces higher yields. Background: Semicarbazones comprise an important structural class of compounds with valuable and diverse biological properties. They are used to synthesize various heterocyclic compounds, which have wide ranges of pharmacological activities...
Published: 9/24/2024   |   Inventor(s): Eric Helms, Jacqueline Bennett
Keywords(s): chemicals, environment, environmental chemistry, organic chemistry, pharmaceuticals, polymers, TAF
Category(s): Technology Classifications > Materials and Chemicals, Campus > SUNY Geneseo, Campus > SUNY Oneonta
Improved drug delivery for solid tumors
A novel formulation paving the way for pancreatic cancer therapeutics Problem Pancreatic cancer therapeutics have a success rate of less than 8%. The solid nature of the tumor in pancreatic cancer renders the current standard of care, chemotherapy drugs, less effective. Unfortunately, the problem lies not with the drugs themselves, but with the drug...
Published: 11/1/2023   |   Inventor(s): Debadyuti Ghosh, Xinquan Liu
Keywords(s): Cancer, Drug delivery, Drug development, Drugs, Pharmaceuticals
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Biologic
BioPod: A platform for increasing efficiency and reducing costs of biomanufacturing
Problem statement Biology can be harnessed to produce a large share of the global economy’s physical materials, potentially with improved performance and sustainability. Fermentation, for centuries used to brew beer and make bread, is now being used to create high-value ingredients such as collagen and spider silk. According to McKinsey, biologically...
Published: 11/1/2023   |   Inventor(s): Hal Alper, Shuo-Fu Yuan, James Wagner, Trevor Johnston, Alshakim Nelson
Keywords(s): 3D printing, Biologics, Industrial manufacturing, Manufacturing, Pharmaceuticals, Synthesis methods
Category(s): Life sciences > Biomaterials, Life sciences > Therapeutics > Manufacturing platform
Antimicrobials From an Epigenetics Based Fungal Metabolite Screening Program
USF researchers have identified five novel antimicrobial compounds applicable against several drug targets such as ESKAPE pathogens, Leishmania donovani, Mycobacterium tuberculosis (TB), Clostridium difficile, Naegleria fowleri, and cancer. These five compounds were isolated via a fungal metabolite screening program. Each compound exhibited specific bioactivity...
Published: 8/25/2023   |   Inventor(s): Bill Baker, Danielle Demers
Keywords(s): Medical Pharmaceuticals, Pharmaceuticals
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Tetrazole & Coumarin Phosphonate Based Broad-Spectrum Beta-Lactamase Inhibitors
Competitive Advantages Combats bacterial antibiotic resistance to β-Lactamase Effectively inhibits against the different classes of β-Lactamase Enhances effectiveness of current β-lactam antibiotics treatments Summary Our inventors have discovered tetrazole and coumarin phosphonate based compounds can actively inhibit...
Published: 6/27/2024   |   Inventor(s): Yu Chen, Orville Pemberton, Adam Renslo, Priyadarshini Jaishankar
Keywords(s): Infectious Diseases Treatment, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Beta-Lactamase Inhibitor Compositions, Methods of Use, and Methods of Treatment
Competitive Advantages Can restore the efficacy of beta-lactam antibiotics Overcomes antibiotic resistance May help to develop new antibiotic treatment regimens Treats multi-drug resistant organisms Summary Our researchers have developed compositions comprised of a beta-lactamase inhibitor and methods of use to treat various infections and...
Published: 6/27/2024   |   Inventor(s): Adam Renslo, Derek Nichols, Priyadarshini Jaishankar, Yu Chen, Erica Lauterwasser
Keywords(s): Infectious Diseases Treatment, Pharmaceuticals
Category(s): Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical
Treatment for Metabolic Syndrome and Obesity Related Diseases
Background Abdominal obesity is the most commonly observed component of metabolic syndrome and a major risk factor for type II diabetes and cardiovascular disease. In addition to obesity, an individual’s risk of cardiovascular disease and type II diabetes is strongly correlated to a series of risk factors, collectively referred to as metabolic...
Published: 8/4/2022   |   Inventor(s): Jan Frederik Stevens, Paul Blakemore, Ines Paraiso, Luce Mattio
Keywords(s): Chemical Synthesis, medicinal, Metabolic syndrome, Obesity, pharmaceuticals, Type 2 Diabetes
Category(s): Therapeutics
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