Search Results - wishrawana+ratnayake

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ICA‑1S and ζ‑Stat: Selective aPKC Inhibitors for Anti‑Angiogenic Control Neuroblastoma
Advantages Upstream pathway control: Suppresses VEGF‑A by targeting aPKC, a master regulator of angiogenic signaling. Selective, small-molecule mechanism: offers lower immunogenicity and easier development than antibody-based therapies. Combination-therapy ready: upstream angiogenic pathway control enables synergy with existing treatments. Summary Neuroblastoma...
Published: 3/6/2026   |   Updated: 2/16/2026   |   Inventor(s): Sloan Breedy, Wishrawana Ratnayake, Mildred Acevedo-Duncan
Keywords(s): Cancer Treatment, Small Molecules
Category(s): Technology Classifications > Cancer, Technology Classifications > Chemistry, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Method for Treating Melanoma using an Inhibitor of an Atypical Protein Kinase C (PKC)
­Advantages: Effectively decreases melanoma cell proliferation and suppresses tumor migration and metastasis. Promotes cancer cell death, specifically targeting melanoma cells and sparing healthy melanocytes. The method not only treats melanoma by targeting atypical PKC isoforms but also utilizes PKC-ι and PKC-ζ levels as biomarkers...
Published: 8/16/2024   |   Updated: 8/16/2024   |   Inventor(s): Mildred Acevedo-Duncan, Wishrawana Ratnayake, David Ostrov
Keywords(s): Cancer Treatment Melanoma
Category(s): Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer > Cancer Diagnostics, Technology Classifications > Cancer > Cancer Treatment Adenocarcinomas, Technology Classifications > Medical > Therapeutics, Technology Classifications > Cancer
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Updated: 11/3/2023   |   Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan, Sloan Breedy, Aaron Todman, Luke Lajmi
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Cancer
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Updated: 11/3/2023   |   Inventor(s): Wishrawana Ratnayake, Mildred Acevedo-Duncan, Kirpal Bisht
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer, Technology Classifications > Medical > Pharmaceuticals
Novel Compounds and Methods for Treating Metastatic Melanoma and Prostate Cancer
­Advantages: Precision Targeting: Selective cancer cell targeting minimizes harm to healthy tissues, enhancing safety. Preclinical Efficacy: Induces cancer cell apoptosis, showing promise for treating metastatic melanoma and prostate cancer. Scientific Rigor: Grounded in robust research, offering innovative oncology solutions. Summary: Metastatic...
Published: 7/11/2024   |   Updated: 11/3/2023   |   Inventor(s): Wishrawana Ratnayake, Kirpal Bisht, Mildred Acevedo-Duncan
Keywords(s): Cancer Treatment Melanoma, Cancer Treatment Prostate Cancer
Category(s): Technology Classifications > Chemistry, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Cancer > Cancer Treatment Melanoma, Technology Classifications > Cancer