Search Results - bin+tan

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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates

Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...

Published: 7/31/2025 | Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li

Keywords(s): Antiviral, Small molecules

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics

Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates

Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...

Published: 7/31/2025 | Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Ahmadullah Ansari, Francesc Ruiz Figueras, Edward Arnold

Keywords(s):

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics

Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates

A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...

Published: 7/31/2025 | Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan

Keywords(s): Antiviral

Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics

SARS-COV-2 papain-like protease inhibitors as antivirals

Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....

Published: 7/9/2025 | Inventor(s): Jun Wang, Edward Arnold, Francesc Ruiz Figueras, Prakash Jadhav, Bin Tan, Ahmadullah Ansari, Ashima Chopra

Keywords(s): Antiviral, Small molecules

Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences

Tunable Degradation of Fibers

Executive Summary Degradation of polymeric materials is an important process in recycling, composting and rendering them innocuous to the environment. Controlling the rate by which the materials degrade remains challenging and impacted by the nature of the materials and their use in applications where combinations of materials exist to fulfil...

Published: 4/29/2025 | Inventor(s): John Dorgan, Bin Tan

Keywords(s):

Category(s): Advanced Materials, Environment, Packaging