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Enterovirus D68 capsid inhibitors as antivirals

Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...

Published: 1/27/2025 | Inventor(s): Jun Wang, Yanmei Hu, Kan Li

Keywords(s): Antibacterial, Small molecules

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics

PLpro Inhibitors Against SARS-CoV-2

There are two cysteine proteases that are encoded by SARS-CoV-2, the main protease (Mpro) and the papain-like protease (PLpro). Both of these proteases have been shown to be essential in viral replication and are validated antiviral drug targets. PLpro cleaves the viral SARS-CoV-2 polyprotein at three sites. In addition, it modulates host immune response...

Published: 7/26/2024 | Inventor(s): Jun Wang, Chunlong Ma, Naoya Kitamura, Yanmei Hu

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Small Molecules

Broad-Spectrum Antivirals Against Enterovirus D68, A71, and Coxsackievirus B3

This invention is a set of compounds which have antiviral activity against the enteroviruses D68, A71, and coxsackievirus B3. They can be used both prophylactically, to prevent infection, and therapeutically, to treat it. Background: Enteroviruses are a group of viruses that belong to the Picornaviridae family. One enterovirus, the polio virus,...

Published: 11/16/2023 | Inventor(s): Jun Wang, Rami Musharrafieh, Chunlong Ma, Jiantao Zhang, Yanmei Hu

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Healthcare Portfolios > Infectious Diseases, Technology Classifications > Life Sciences > Therapeutics