Search Results - mimetics

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In-vivo System to Interrogate the Functions of Mucous Membranes and Identify Mucin/Glycan Mimetics and JAK/STAT Inhibitors for the Treatment of Diseases of the Oral Cavity and Digestive Tract
This technology includes a Drosophila mutant strain that can be used as an in vivo model for diseases of the oral cavity and digestive tract (Sjogren's syndrome, colitis, colon cancer, inflammatory bowel disease), where the mucous membrane is disrupted or non-functional. This mutant lacks a mucous membrane and displays epithelial cell damage, uncontrolled...
Published: 12/26/2024   |   Inventor(s): Liping Zhang, Kelly Ten Hagen
Keywords(s): FUNCTIONS, IDENTIFY, Inhibitors, Interrogate, Jak/STAT, MEMBRANES, MIMETICS, Mucin/glycan, Mucous, System, Vivo, VPXXXX, WIXXXX, XEXXXX
Category(s): TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Cardiology
Small Molecule Humanin Mimetics and Enhancers That Normalize Neuronal p-AKT as Novel Therapeutics for Alzheimer's Disease (UCLA Case No. 2023-230)
UCLA researchers in the Department of Neurology have discovered novel small molecule humanin mimetics for the treatment of Alzheimer's disease and other chronic conditions with dysregulated p-Akt. BACKGROUND: Alzheimer’s disease (AD) is the most common form of dementia accounting for 60-70% of all cases. Nearly 7 million Americans are living...
Published: 7/22/2024   |   Inventor(s): Varghese John
Keywords(s): Alzheimers disease, Cardiovascular, Cardiovascular Disease, Dementia, diabetes, mimetics, pAKT signaling, small molecules
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Cardiovascular
Boron Amino Acid Mimetics for PET Imaging of Cancer
Available for licensing and commercial development as imaging agents for positron emission tomography of cancer are boramino acid compounds. The inventors showed that mimetics created by substituting the carboxylate group (-COO-) of an amino acid with trifluoroborate (-BF3-) are metabolically stable and allow for the use of fluorene-18 (18F) as the...
Published: 10/28/2024   |   Inventor(s): Zhibo Liu, Xiaoyuan (Shawn) Chen
Keywords(s): AA3CXX, Boramino, CA1CXX, CA2BXX, CA2CXX, Cancer diagnosis, Cancer diagnostic, fluorene-18, Mimetic, MIMETICS, positron emission, VCXXXX, WBXXXX, WIXXXX, XFXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Medical Devices, Application > Diagnostics, Application > Non-Medical Devices, Application > Software / Apps, TherapeuticArea > Oncology
Salen-Manganese Compounds for Therapy of Viral Infections
Salen-manganese compounds are synthetic, stable, low toxicity, low cost agents that may provide protection from immune reaction-related oxidative cell damage associated with many illnesses. In particular, oxidative cell damage has been associated with many viral infections including influenza. This invention demonstrates that treating mice with salen-manganese...
Published: 10/28/2024   |   Inventor(s): Jeffery Taubenberger, Rodney Levine, Susan Doctrow, John Kash
Keywords(s): Catalase/Superoxide, DB4BXX, DB4XXX, DBXXXX, DISMUTASE, DXXXXX, INFECTIONS, MIMETICS, Synthetic, viral
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Infectious Disease