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Search Results - neuroscience
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Fenchol: A Natural Therapeutic for Cognitive Health and Neurodegenerative Care
Advantages Targeting neuroinflammation and proteostasis Strong preclinical efficacy in cells, C. elegans, and Alzheimer’s mouse models GRAS-designated natural compound with excellent safety profile Multiple delivery formats: oral, nasal, buccal, topical, supplement Summary Neurodegenerative diseases such as Alzheimer’s Disease (AD)...
Published: 8/4/2025
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Inventor(s):
Hariom Yadav
,
Shalini Jain
,
Sidharth Mishra
Keywords(s):
Neurodegenerative Diseases
,
Neuroscience
,
Nutrition / Diet Health
Category(s):
Technology Classifications > Medical
,
Technology Classifications > Medical >
Neuroscience
Conditional Hs3st1/4/5 Mouse Lines for In-vivo Study of Heparan Sulfate (HS)
Advantages: Cell and Stage-specific Cre-loxP mediated ablation of Hs3st1/4/5 First-ever floxed alleles for Hs3st4 and Hs3st5 Captures complex neurological and behavioral phenotypes Evaluates drugs on HS pathways and 3-O-sulfation dependent motifs Summary: Heparan sulfate (HS) is a polysaccharide which plays a vital role in various biological...
Published: 6/26/2025
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Inventor(s):
Lianchun Wang
Keywords(s):
Animal Models
,
Neuroscience
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Medical >
Neuroscience
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI • Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...
Published: 5/30/2025
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Inventor(s):
Travis Jackson
Keywords(s):
Animal Models
,
Neuroscience
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Medical >
Neuroscience
,
Technology Classifications > Medical > Biotechnology
Computerized Cognitive Training for Insomnia (COGMUSE)
Advantages Gamified cognitive training that is aimed at adults with both autism and insomnia Flexibility in terms of the ability to incorporate user feedback Summary Older adults with insomnia as well as autistic adults with co-occurring insomnia often struggle with persistent cognitive and sleep disturbances. These issues are only marginally...
Published: 7/17/2025
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Inventor(s):
Ashley Curtis
Keywords(s):
Biotechnology
,
Computer Science
,
Computers Software and Information Technology
,
Health Tech
,
Human Computer Interfaces
,
Neuroscience
,
Psychiatry / Mental Health
,
Therapeutics
Category(s):
Technology Classifications > Computer Science > Computers Software & Information Technology
,
Technology Classifications > Medical >
Neuroscience
,
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Engineering > Computer Engineering
Treating Covid-19 Infection-Induced Dementia
Advantages: Novel gene therapy targeting FKBP5 and IFI204 to disrupt tauopathy-related signaling Targeted RNA delivery utilizing dendriplex nanoparticles to silence SARS-CoV-2 induced neurodegenerative pathways Preclinical animal studies indicate reduction of neuroinflammation and tau accumulation Intranasal delivery bypasses the blood-brain...
Published: 8/22/2025
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Inventor(s):
Subhra Mohapatra
,
Shyam Mohapatra
,
Karthick Mayilsamy
Keywords(s):
Covid-19
,
Neuroscience
Category(s):
Technology Classifications > Medical > Infectious Diseases
,
Technology Classifications > Medical >
Neuroscience
,
Technology Classifications > Medical > Therapeutics
A New High-Throughput Cell Biology Method to Screen for Genes Critical for Cell Differentiation
A high-throughput method for identifying genes involved in the process of stem cell differentiation into specialized cells. Background: One of the many draws of stem cells is their potential for regenerating tissues, nerves, and other organs, but the differentiation potential of stem cells is highly regulated by genes. Therefore, the ability to...
Published: 5/13/2025
|
Inventor(s):
Chunyu Liu
Keywords(s):
cell culture
,
development
,
differentiation
,
high-throughput
,
neuroscience
,
regenerative medicine
,
screen
Category(s):
Campus > Upstate Medical University
,
Technology Classifications > Therapeutics and Vaccines
Binding Between TREM2 and Heparan Sulfate Delineates the Role of Microglia in AD and Reveals Novel Treatment Strategies
Advantages: Discovered novel structural interactions between HS and TREM2, associated with neurodegeneration High-affinity binding: TREM2 specifically interacts with Heparan Sulfate (HS) modified with 6-O-sulfation and iduronic acid, enabling precise microglial modulation compared to broad-spectrum anti-inflammatory strategies Defined structural...
Published: 8/12/2025
|
Inventor(s):
Lianchun Wang
,
Ilayda McMillan
Keywords(s):
Immunology
,
Neurodegenerative Diseases
,
Neuroscience
Category(s):
zzNeurodegenerative Diseases Treatment
,
Technology Classifications > Medical >
Neuroscience
,
Technology Classifications > Medical > Therapeutics
Electrical Stimulation for Acute Stroke (Case No. 2020-787)
Summary: Researchers at the UCLA Department of Neurology have developed an individualized method of delivering non-invasive electrical stimulation to treat acute human ischemic stroke. Background: Stroke is a leading cause of mortality and morbidity across the world. Over 80% of strokes are ischemic due to blockage of blood vessels, causing a low...
Published: 2/14/2025
|
Inventor(s):
Mersedeh Bahr Hosseini
,
Jeffrey Saver
,
Marom Bikson
Keywords(s):
Acute ischemic stroke
,
CNS Rehabilitation
,
Electrical
,
Electrical Engineering
,
Electrical stimulation
,
Neurocognitive
,
Neuroimaging
,
Neurointervention
,
neurological disorders
,
Neurology
,
Neuromodulation
,
Neuron
,
Neuropathology
,
Neuropsychological Test
,
neuroscience
,
Neurostimulation
,
Neurosurgery
,
soft electrical circuits
,
Stroke
,
Stroke Geriatrics Energy Accounting Local Area Network
,
stroke rehabilitation
,
stroke therapeutics
,
Transcutaneous Electrical Nerve Stimulation
Category(s):
Electrical
,
Electrical > Flexible Electronics
,
Medical Devices
,
Medical Devices > Cardiac
,
Medical Devices > Hospital Systems
Stimulation of Parvalbumin Neurons to Enhance Recovery After Stroke (UCLA Case No. 2024-131)
UCLA researchers from the Department of Neurology have discovered a molecular compound that promotes activation of parvalbumin neurons in the brain, enhancing behavioral recovery after stroke. BACKGROUND: Stroke is a leading cause of death and disability worldwide. According to the World Health Organization, approximately 15 million people suffer from...
Published: 7/17/2025
|
Inventor(s):
Stanley Carmichael
Keywords(s):
Cns
,
Neurology
,
neuroscience
,
parvalbumin neurons
,
spinal cord
,
Stroke
,
stroke rehabilitation
,
stroke therapeutics
Category(s):
Therapeutics > CNS and Neurology
The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024
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Inventor(s):
Travis Jackson
Keywords(s):
Animal Models
,
Lab Apparatus
,
Laboratory Devices
,
Neuroscience
,
Research Tools
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Medical Devices
,
Technology Classifications > Medical >
Neuroscience
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