Search Results - neuroscience

20 Results Sort By:
Stimulation of Parvalbumin Neurons to Enhance Recovery After Stroke (UCLA Case No. 2024-131)
UCLA researchers from the Department of Neurology have discovered a molecular compound that promotes activation of parvalbumin neurons in the brain, enhancing behavioral recovery after stroke. BACKGROUND: Stroke is a leading cause of death and disability worldwide. According to the World Health Organization, approximately 15 million people suffer from...
Published: 8/28/2024   |   Inventor(s): Stanley Carmichael
Keywords(s): Cns, Neurology, neuroscience, parvalbumin neurons, spinal cord, Stroke, stroke rehabilitation, stroke therapeutics
Category(s): Therapeutics > CNS and Neurology
The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
­Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Lab Apparatus, Laboratory Devices, Neuroscience, Research Tools
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience
Secreted UBE3A for the Treatment of Neurological Disorders
­Advantages: Novel vector, composition, and method of treating a neurological disorder with UBE3A deficiency. High fidelity to human Angelman syndrome. Facilitates comprehensive symptom representation for diverse treatment investigations. Allows innovative experiments for pioneering treatment development. Summary: Angelman...
Published: 1/2/2024   |   Inventor(s): Kevin Nash
Keywords(s): Animal Models, Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience
Investigating the Role of BIN1's SH3 Domain in Alzheimer's Desease
­Advantages: The approach of targeting BIN1, a gene associated with AD increases the likelihood of finding effective therapeutic interventions. Determining the crystal structure of BIN1's SH3 domain provides detailed structural information which is crucial for designing small molecule inhibitors. The research reports promising preliminary...
Published: 1/23/2024   |   Inventor(s): Gopal Thinakaran
Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience, Small Molecules
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics
UBE3A Gene Therapy for the Treatment of Tauopathies
Advantages: Reduction in Pathology Improved Memory and Cognitive Function Targeted Delivery and Brain-wide Distribution Business Summary: Alzheimer’s disease (AD) is a neurodegenerative disease that involves the accumulation of A-Beta proteins and Tau proteins within the brain and leads to cognitive impairments. The accumulation of these...
Published: 9/26/2023   |   Inventor(s): Jazmin Pena, Kevin Nash
Keywords(s): Medical Diagnostics, Neurodegenerative Diseases, Neuroscience, Therapeutics
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Therapeutics
A New High-Throughput Cell Biology Method to Screen for Genes Critical for Cell Differentiation
A high-throughput method for identifying genes involved in the process of stem cell differentiation into specialized cells. Background: One of the many draws of stem cells is their potential for regenerating tissues, nerves, and other organs, but the differentiation potential of stem cells is highly regulated by genes. Therefore, the ability to...
Published: 7/11/2023   |   Inventor(s): Chunyu Liu
Keywords(s): cell culture, development, differentiation, high-throughput, neuroscience, regenerative medicine, screen
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy
Use of Auranofin for Treatment of Neurodegenerative Disorders
­Competitive Advantages Potential treatment for Alzheimer’s, FTD, and other neurodegenerative disorders Results show that various factors including insulin lead to activation of aPKC and the NFkappa-B inflammatory pathway in brain neurons and glial cells Auranofin (AF) is an FDA approved drug for other uses, thus relatively easy to conduct...
Published: 1/25/2024   |   Inventor(s): Robert Farese, Mini Sajan
Keywords(s): Medical Pharmaceuticals, Neurodegenerative Diseases, Neuroscience
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
A Software Model for Mapping Negative Epilepsy Network in Brain
Competitive Advantages A non-invasive method that improves the chances of the cure of epilepsy Increases the efficacy of surgery by generating a negatively correlated epilepsy model which represents a protective anti-seizure network to be preserved in the surgery This software algorithm needs readily available on the desk equipment to produce the...
Published: 7/12/2023   |   Inventor(s): Elliot Neal, Fernando Vale
Keywords(s): Neuroscience, Surgery, Surgical Tools
Category(s): Technology Classifications > Computer Science > Algorithms, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Imaging, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Surgery
Accounting for Affect in Pain Level Recognition
­Competitive Advantages Differentiates between pain and non-pain stimuli Assesses pain in a real-world setting Might help doctors know the criticality of the injury based on the accurate pain measurement Will help detect the pain level of babies and unconscious patients Summary Automated pain assessment is an essential component in clinical...
Published: 9/25/2023   |   Inventor(s): Shaun Canavan, Md Taufeeq Uddin, Ghadh Alzamzmi
Keywords(s): Image Tracking, Medical Devices, Medical Imaging, Neuroscience, Pain Relief / Management, Sensor
Category(s): Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Imaging
Creation Of Split Tau Oligomerization Assay
Competitive Advantages Allows for live-cell measurement of tau oligomerization A valuable tool for investigating tau oligomer modifying drugs Summary Oligomeric tau species are crucial to induce tau transmission between neurons and toxicity within neurons. USF investigators established a novel technique to measure tau oligomierization via visualizing...
Published: 9/25/2023   |   Inventor(s): Daniel Lee, Chao Ma
Keywords(s): Medical Diagnostics, Medical Pharmaceuticals, Neuroscience
Category(s): Technology Classifications > Medical > Medical Diagnostics
1 2