Search Results - scaffolds

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3D Scaffold for T Cell Delivery and Suppression of Tregs for Solid Tumors (UCLA Case No. 2020-193)
SUMMARY: UCLA researchers in the Department of Bioengineering have developed a small and biodegradable implant that when placed adjacent to solid tumors, enhances immune response to cancer cells. BACKGROUND: The body’s immune system uses proteins called antibodies to train the immune response to foreign pathogens. This mechanism can combat...
Published: 12/3/2024   |   Inventor(s): Manish Butte
Keywords(s): cytokines, Drug Delivery, Immunotherapy, Nanoparticles, scaffolds, solid tumors, T-cell activation, t-cells
Category(s): Platforms > Drug Delivery > Nanoparticles
2023-102 A Dynamic Cholesteric Liquid Crystal for Organoid, Spheroid, 3D Cell Aggregate Manufacturing
Summary: UCLA and University of Connecticut researchers have engineered a novel liquid-crystal-based biomaterial with a simple fabrication process for organoid, spheroid and 3D cell aggregate manufacturing that enables rapid cell growth. Background: The current waiting list for people who need a lifesaving organ transplant is over 100,000 cases...
Published: 7/19/2023   |   Inventor(s): Paul Weiss, Amir Nasajpour, Ali Tamayol, Mohamadmahdi Samandari
Keywords(s): 3D biofabrication, 3D Printing, Biocompatibility, biocompatible, Biomaterial 3D Printing, biomedical implantation, Cell and tissue culture, Cell Culture, cell-extracellular matrix (ECM), cellular aggregates, Cellular agriculture, Cholesterol, cholesteryl ester liquid crystals (CLCs), Cultured meat, Electrode 3D Printing, liquid crystal, liquid crystal nanofibers, mesogens, Organ Transplant, organogenesis, scaffolds, self-assemble, Stem Cells / Regenerative Medicine, Tissue Engineering
Category(s): Chemical, Chemical > Polymers, Materials, Materials > Functional Materials, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Other Reagents, Medical Devices, Medical Devices > Surgical Tools, Therapeutics, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
Novel System for HIV-1 Vaccine Development
The available technologies describe specific immunogenic peptides, peptide modifications and methods for identifying additional immunogens against HIV-1 surface proteins, gp120 and gp41. Additionally, detailed methods for use of the described immunogenic peptides in the development of vaccines and diagnostics for HIV-1 are disclosed. The current technologies...
Published: 10/28/2024   |   Inventor(s): Peter Kwong
Keywords(s): Against, ANTIGENIC, Anti-HIV-1, ATOMIC, Biotechnology, Broadly, CONFORMATIONALLY, Cryptic, DC5AXX, DC5XXX, DCXXXX, DEFINITION, Details, DXXXXX, Ectodomain, ELICIT, Envelope, Epitope, Epitopes, Epitope-transplant, FUNCTION, Gp120:, gp41, HIV, HIV-1, Immunization, IMMUNOGENS, Level, Membrane-Proximal, Neutralizing, Patent Category - Biotechnology, Reveal, Scaffolds, Stabilized, Strategies, structure, Their, Triggering, V3-Loop, Vaccine
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines