Search Results - gopal+thinakaran

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A novel mouse model (TRE-HuAmy line) to achieve spatial and temporal control of human amylin transgene expression
Advantages Enables the in vivo switching on or off human amylin expression through the administration/ withdrawal of DOX Spatially restricted transgene activation: crossing tissue-specific rtTA/tTA lines achieves localized amylin expression without off-target effects. Single-copy Rosa26 knock-in for consistent expression: integration at Rosa26...
Published: 6/3/2025   |   Inventor(s): Gopal Thinakaran, Florin Despa
Keywords(s):  
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Neuroscience, zzDiabetes
YTH Domain-Containing Family Protein 1 (YTHDF1): A Novel Therapeutic Target for Alzheimer’s Disease
Advantages: A novel method for targeting m6A methylation via YTHDF1 offers a potential therapy for tauopathies and Alzheimer’s disease YTHDF1 reduces neuroinflammation in Alzheimer’s disease by downregulating pro-inflammatory genes like Ccl6 and Cst7 Enhance working memory and reduce hyperactivity in tauopathy, suggesting cognitive...
Published: 5/11/2025   |   Inventor(s): Gopal Thinakaran, Shuai Wang
Keywords(s): Animal Models, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics, Technology Classifications > Computer Science
Investigating the Role of BIN1's SH3 Domain in Alzheimer's Desease
­Advantages: The approach of targeting BIN1, a gene associated with AD increases the likelihood of finding effective therapeutic interventions. Determining the crystal structure of BIN1's SH3 domain provides detailed structural information which is crucial for designing small molecule inhibitors. The research reports promising preliminary...
Published: 1/23/2024   |   Inventor(s): Gopal Thinakaran
Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience, Small Molecules
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics