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Search Results - gopal+thinakaran
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YTH Domain-Containing Family Protein 1 (YTHDF1): A Novel Therapeutic Target for Alzheimer’s Disease
Advantages: A novel method for targeting m6A methylation via YTHDF1 offers a potential therapy for tauopathies and Alzheimer’s disease YTHDF1 reduces neuroinflammation in Alzheimer’s disease by downregulating pro-inflammatory genes like Ccl6 and Cst7 Enhance working memory and reduce hyperactivity in tauopathy, suggesting cognitive...
Published: 3/6/2025
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Inventor(s):
Gopal Thinakaran
,
Shuai Wang
Keywords(s):
Animal Models
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Therapeutics
Investigating the Role of BIN1's SH3 Domain in Alzheimer's Desease
Advantages: The approach of targeting BIN1, a gene associated with AD increases the likelihood of finding effective therapeutic interventions. Determining the crystal structure of BIN1's SH3 domain provides detailed structural information which is crucial for designing small molecule inhibitors. The research reports promising preliminary...
Published: 1/23/2024
|
Inventor(s):
Gopal Thinakaran
Keywords(s):
Medical Therapeutics Gene Therapy
,
Neurodegenerative Diseases
,
Neuroscience
,
Small Molecules
Category(s):
Technology Classifications > Medical > Therapeutics
,
Technology Classifications > Medical > Pharmaceuticals
,
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Medical Diagnostics