Search Results - mouse+model

13 Results Sort By:
Knockout and Conditional Knockout Mice-GPR116
Abstract: Pulmonary surfactant plays a critical role in preventing alveolar collapse by decreasing surface tension at the alveolar air-liquid interface. Surfactant deficiency contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), common disorders that can afflict patients of all ages and carry a mortality...
Published: 12/6/2024   |   Inventor(s): Brad St. Croix, Mi Young Yang
Keywords(s): acute lung injury, Acute respiratory distress syndrome, GPR116, lung surfactant homeostasis, mouse model
Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
A Preclinical Orthotopic Model for Glioblastoma Multiforme that Represents Key Pathways Aberrant in Human Brain Cancer
Abstract: Current therapies for glioblastoma multiforme (GBM), the highest grade malignant brain tumor, are mostly ineffective, and better preclinical model systems are needed to increase the successful translation of drug discovery efforts into the clinic. Scientists at the National Cancer Institute (NCI) have developed and characterized an orthotopic...
Published: 4/8/2024   |   Inventor(s): Zoe Ohler, Rajaa El Meskini, Anthony Lacovelli, Alan Kulaga, Michelle Gumprecht, Terry Van Dyke
Keywords(s): Brain Cancer, GBM, GEM, Genetically Engineered Mouse, Meskini, mouse model, Multiforme, Ohler Weaver, Orthotopic Glioblastoma
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Neurology
A Preclinical Model for Mutant Human EGFR-driven Lung Adenocarcinoma
Abstract: Previously described epidermal growth factor receptor- (EGFR) driven tumor mouse models develop diffuse tumors, which are dissimilar to human lung tumor morphology and difficult to measure by CT and MRI scans. Scientists at the National Cancer Institute (NCI) have developed and characterized a genetically engineered mouse (GEM) model of human...
Published: 4/8/2024   |   Inventor(s): Simone Difilippantonio, Lionel Feigenbaum, Deborah Householder, Philip Martin, Zoe Ohler, Terry Van Dyke
Keywords(s): EGFR, Epidermal Growth Factor Receptor, GEM, Genetically Engineered Mouse, Lung adenocarcinoma, lung cancer, mouse model, Ohler Weaver, respiratory
Category(s): Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Genetically Engineered Mouse-Derived Allograft for Preclinical Studies of Metastatic Melanoma
Abstract: The invention listed below is owned by an agency of the U.S. Government and is available for licensing and/or co-development in the U.S. in accordance with 35 U.S.C. 209 and 37 CFR part 404 to achieve expeditious commercialization of results of federally-funded research and development. Before testing drugs in humans, drug developers are required...
Published: 5/23/2024   |   Inventor(s): Chi-Ping Day, Glenn Merlino, Zoe Ohler, Rajaa El Meskini, Terry Van Dyke, Thomas Tuting
Keywords(s): Allograft, GDA, Genetically Engineered Mouse-Derived Allograft, MELANOMA, Metastasis, mouse model, Preclinical, therapeutics
Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Mouse Xenograft Model for Mesothelioma
Abstract: The National Cancer Institute is seeking parties interested in collaborative research to co-develop, evaluate, or commercialize a new mouse model for monoclonal antibodies and immunoconjugates that target malignant mesotheliomas.  Applications of the technology include models for screening compounds as potential therapeutics for mesothelioma...
Published: 12/6/2024   |   Inventor(s): Mitchell Ho
Keywords(s): ASBESTOS, CANCER, Immunoconjugate, malignant mesothelioma, mouse model, RESEARCH TOOL, SS1P
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Licensing
Syringe Stabilization Device for Ultrasound-Guided Procedures (UCLA Case No. 2023-045)
Summary: UCLA researchers in the Department of Surgery have developed a novel, minimally invasive ultra-sounded guided metastatic mouse model and device enabling more secure and precise usage of in-plane ultrasound imaging of needles. Background: Cancer is the second leading cause of death globally and in the United States. Pancreatic cancer remains...
Published: 11/8/2023   |   Inventor(s): Amanda Labora
Keywords(s): Breast Cancer, Cancer, cancer detection, Cancer Immunotherapy, Catheterization, In-plane ultrasound, Intratumoral drug delivery, Metastasis, metastatic mouse model, Mouse model, Orthotopic cancer models, Pancreatic cancer, Preclinical model development, Preclinical surgical innovation
Category(s): Life Science Research Tools, Life Science Research Tools > Animal Imaging, Life Science Research Tools > Animal Models, Medical Devices > Medical Imaging, Therapeutics, Therapeutics > Oncology, Medical Devices > Medical Imaging > Ultrasound
Transgenic Human Interleukin-21 Mouse Model
Available for licensing is a mouse model that constitutively expresses human interleukin-21 (IL-21). Traditionally, human IL-21 transgenic mouse models are difficult to produce as those with high IL-21 levels exhibit growth retardation and die before sexual maturity. The investigators generated transgenic mice that express human IL-21, which can stimulate...
Published: 10/28/2024   |   Inventor(s): Katsutoshi Ozaki, Warren Leonard
Keywords(s): AC5XXX, ACXXXX, AXXXXX, CCXXXX, CXXXXX, IDXXXX, IL-21, INTERLEUKIN, interleukin 21, IXXXXX, Mice, Mouse, Mouse animal model, mouse model, TRANSGENIC
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics
Mouse Model for Cerebral Cavernous Malformation, an Inherited Brain Disorder
Cerebral Cavernous Malformation (CCM) is a brain disease affecting up to 0.5% of the worldwide population. CCM is characterized by grossly dilated vessels prone to leaking and hemorrhage which result in severe headaches, seizures, and strokes. Inherited forms of the disease are due to mutations in one of three loci, CCM1, CCM2, and CCM3. Prior efforts...
Published: 10/28/2024   |   Inventor(s): YoSuke Mukoyama, Ulrich Siebenlist (Estate)
Keywords(s): brain, Cavernous Cerebral Malformation, CCM, CEREBRAL, Conditional, Cre, cre-lox, Floxed, Human, IDXXXX, Inherited, IXXXXX, Mouse, mouse model, RXXXXX
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
A Mouse Model of Multiple Endocrine Neoplasia, Type I
The current invention embodies a mouse model which is heterozygous for a null allele at the Men1 locus of murine chromosome 19. Men1 has similar exon-intron organization and amino acid identity compared with its human analog MEN1, which has been implicated in the pathogenesis of multiple endocrine neoplasia, type I (MENI). This mouse model has been...
Published: 8/12/2024   |   Inventor(s): Judy Crabtree, Francis Collins
Keywords(s): CC1XXX, CC3XXX, CCXXXX, CXXXXX, endocrine, GB1A3X, GB1AXX, GB1XXX, GB2BXX, GB2XXX, GBXXXX, GCXXXX, GXXXXX, Men1 locus, Model, Mouse, mouse model, MULTIPLE, Multiple endocrine neoplasia, Multiple endocrine neoplasia type 1, Multiple endocrine neoplasia, type 2, murine chromosome 19, NEOPLASIA, tumor formation, TYPE, Zollinger-Ellison syndrome
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Oncology
A Gene Knockout Mouse Model to Study Lung Disease and a Lung Disease Drug Target
Our researchers have created a gene knockout mouse model that lacks the cytochrome c oxidase subunit IV-2 in order to study the gene’s effects on controlling asthma. Background & Unmeet Need: Asthma is an inflammatory disease of the airways that affects 155 million people of all ages worldwide. Cytochome c oxidase (CcO) is a multi-subunit...
Published: 12/17/2024   |   Inventor(s): Maik Huettemann, Lawrence Grossman, David Bassett
Keywords(s): Asthma, Disease, Drug Target, Gene, Knock-out, Lung, Mouse Model
Category(s): Animal models, Biological materials, Life Science, Research tools, Protein/peptides
1 2