Search Results - inflammatory+diseases

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A Human Origin Probiotics- Lactobacillus Rhamnosus HL-200 to Reduce Leaky Gut by Metabolizing Ethanolamine
­Advantages Might be an effective treatment for leaky gut syndrome associated chronic inflammation. The novel probiotic induces ethanolamine metabolizing activity thus strengthening the gut barrier. Might help evade from several other diseases causes by leaky gut syndrome. Summary Leaky gut syndrome is a key source of chronic inflammation,...
Published: 5/16/2024   |   Inventor(s): Hariom Yadav, Shalini Jain, Sidharth Mishra
Keywords(s): Diabetes, Inflammatory Diseases, Medical Pharmaceuticals, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics
Shift of Metabolic ATP Production and Cellular Oxygen Consumption
Competitive Advantages Increased endothelial cell anaerobic glycolysis Edema prevention Enhanced endothelial barrier function A potential treatment for many diseases Summary Our researchers have developed a method which utilizes agents that activate σ1. The activation of σ1 encourages the metabolic production of...
Published: 11/16/2023   |   Inventor(s): Jerome Breslin, Zeinab Motawe
Keywords(s): Cardiovascular Diseases, Diabetes, Inflammatory Diseases, Stroke Treatment, Therapeutics
Category(s): Technology Classifications > Medical
2013-741 Bioengineered Thymic Aggregates for Implantation
Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...
Published: 7/19/2023   |   Inventor(s): Gay Crooks, Amelie Montel Hagen, Brile Chung
Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy
2019-641 LATE TRANSITION METAL MEDIATED BASE PAIRS AND APPLICATIONS IN BIOTECHNOLOGY AND SYNTHESIS
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method of metal-mediated base pair stabilization in vivo, with additional applications in the detection of small nucleic acids and regulation of transition metal catalysis. BACKGROUND:Recent studies of the interactions between transition metals and DNA have led...
Published: 7/19/2023   |   Inventor(s): Hosea Nelson
Keywords(s): Catalysts, Chemical Manufacturing & Industrial/Bulk Chemicals, Inflammatory Diseases, Life Science Research Tools, Other, Therapeutics & Vaccines
Category(s): Chemical > Synthesis, Therapeutics > Inflammation And Inflammatory Diseases
2019-876 MAINTAINING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION
UCLA researchers in the Departments of Dentistry and Plastic Surgery have developed a novel suppressor of Npas2 for the regeneration of connective tissues.BACKGROUND:Open wounds of the skin and oral cavity are subject to infection and scarring if not properly closed. Patients may experience a variety of social consequences due to unclosed wounds of...
Published: 7/19/2023   |   Inventor(s): Ichiro Nishimura, Akishige Hokugo, Hodaka Sasaki, Hiroko Okawa, Lixin Wang
Keywords(s): Dental, Inflammatory Diseases, Therapeutics & Vaccines
Category(s): Therapeutics > Dental, Therapeutics > Inflammation And Inflammatory Diseases
2019-958 SELECTIVE HDAC INHIBITORS
UCLA researchers in the Department of Chemistry and Biochemistry have synthesized a series of novel hydroxamic acids and derivatives as selective histone deacetylase (HDAC) inhibitors from simple starting materials.BACKGROUND:Histone deacetylase (HDAC) inhibitors are chemical compounds that regulates gene expression by inhibiting histone deacetylases....
Published: 7/19/2023   |   Inventor(s): Michael Jung, Jonghoon Kim
Keywords(s): Chemical Manufacturing & Industrial/Bulk Chemicals, Cns, Gene Editing Systems, Gene Therapy, Infectious Diseases, Inflammatory Diseases, Therapeutics & Vaccines
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Infectious Diseases, Therapeutics > Gene Therapy And Editing, Therapeutics > Inflammation And Inflammatory Diseases, Chemical > Industrial & Bulk Chemicals
2019-731 EARLY PREDICTION OF PROGRESSION IN IDIOPATHIC PULMONARY FIBROSIS USING A SINGLE TIME POINT HRCT SCAN
Summary: UCLA researchers in the Department of Radiological Sciences have developed a novel single time point high-resolution computed tomography (HRCT) scan method for the early prediction of idiopathic pulmonary fibrosis disease progression. Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease that results in scarring of the lungs...
Published: 7/12/2024   |   Inventor(s): Hyun (Grace) Kim, Jonathan Gerald Goldin
Keywords(s): CT, Diagnostic Markers & Platforms, Inflammatory Diseases, Life Science Research Tools, Medical Imaging, Microscopy And Imaging
Category(s): Life Science Research Tools > Microscopy And Imaging, Medical Devices > Medical Imaging > CT, Therapeutics > Inflammation And Inflammatory Diseases
2019-468 PERIODONTAL MICROPATCH AND USES THEREOF
INTRODUCTION:UCLA researchers in the Departments of Bioengineering and Dentistry have developed a patch-based drug delivery system for dental applications.BACKGROUND:Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth, and it is estimated that 50% of the U.S. population suffers from some type of periodontal disease....
Published: 7/19/2023   |   Inventor(s):  
Keywords(s): Dental, Drug Delivery, Inflammatory Diseases, Medical Devices and Materials, Other Polymers
Category(s): Platforms > Drug Delivery > Other Polymers
2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration
Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...
Published: 7/19/2023   |   Inventor(s): John Chute, Michael Jung, Emelyne Diers
Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology
Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
Wide-Field Imaging Of Birefringent Crystals In Synovial Fluid Using Lens-Free Polarized Microscopy For Crystal Arthropathy Diagnosis
UC Case No. 2016-848SUMMARYUCLA researchers in the Department of Electrical Engineering have developed a new diagnostic tool for arthropathic diseases, such as gout.BACKGROUNDConventionally, the diagnosis of gout relies on the observation of monosodium urate (MSU) crystals in synovial fluid aspirated from the joint of the patient and then examined under...
Published: 7/19/2023   |   Inventor(s): Yibo Zhang, Aydogan Ozcan, Seung Yoon Lee
Keywords(s): Autoimmune, Inflammatory Diseases, Medical Imaging
Category(s): Therapeutics > Autoimmune, Medical Devices > Medical Imaging, Therapeutics > Inflammation And Inflammatory Diseases
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