Search Results - inflammatory+diseases

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A Human Origin Probiotics- Lactobacillus Rhamnosus HL-200 to Reduce Leaky Gut by Metabolizing Ethanolamine
­Advantages Might be an effective treatment for leaky gut syndrome associated chronic inflammation. The novel probiotic induces ethanolamine metabolizing activity thus strengthening the gut barrier. Might help evade from several other diseases causes by leaky gut syndrome. Summary Leaky gut syndrome is a key source of chronic inflammation,...
Published: 5/16/2024   |   Inventor(s): Hariom Yadav, Shalini Jain, Sidharth Mishra
Keywords(s): Diabetes, Inflammatory Diseases, Medical Pharmaceuticals, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Therapeutics
Shift of Metabolic ATP Production and Cellular Oxygen Consumption
Competitive Advantages Increased endothelial cell anaerobic glycolysis Edema prevention Enhanced endothelial barrier function A potential treatment for many diseases Summary Our researchers have developed a method which utilizes agents that activate σ1. The activation of σ1 encourages the metabolic production of...
Published: 11/16/2023   |   Inventor(s): Jerome Breslin, Zeinab Motawe
Keywords(s): Cardiovascular Diseases, Diabetes, Inflammatory Diseases, Stroke Treatment, Therapeutics
Category(s): Technology Classifications > Medical
2013-741 Bioengineered Thymic Aggregates for Implantation
Bioengineered Thymic Aggregates For ImplantationSUMMARYResearchers led by Gay Crooks from the Department of Pathology and Laboratory Medicine at UCLA have bioengineered a thymus implant to treat immune diseases.BACKGROUNDThe thymus plays an important role in the immune cells by producing specialized white blood cells called T cells. Thymus implantation...
Published: 2/14/2025   |   Inventor(s): Gay Crooks, Amelie Montel-Hagen, Brile Chung
Keywords(s): Autoimmune, Drug Delivery, Hematology, Inflammatory Diseases, Other Polymers, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery, Therapeutics > Autoimmune, Therapeutics > Hematology, Platforms > Drug Delivery > Other Polymers, Therapeutics > Immunology And Immunotherapy
2019-876 MAINTAINING FUNCTIONS AND PHENOTYPES OF CONNECTIVE TISSUE THROUGH NPAS2 SUPPRESSION
UCLA researchers in the Departments of Dentistry and Plastic Surgery have developed a novel suppressor of Npas2 for the regeneration of connective tissues.BACKGROUND:Open wounds of the skin and oral cavity are subject to infection and scarring if not properly closed. Patients may experience a variety of social consequences due to unclosed wounds of...
Published: 7/17/2025   |   Inventor(s): Ichiro Nishimura, Akishige Hokugo, Hodaka Sasaki, Hiroko Okawa, Lixin Wang
Keywords(s): Dental, Inflammatory Diseases, Therapeutics & Vaccines
Category(s): Therapeutics > Dental, Therapeutics > Inflammation And Inflammatory Diseases
Early Prediction of Progression in Idiopathic Pulmonary Fibrosis Using a Single Time Point HRCT Scan (Case No. 2019-731)
Summary: UCLA researchers in the Department of Radiological Sciences have developed a novel single time point high-resolution computed tomography (HRCT) scan method for the early prediction of idiopathic pulmonary fibrosis disease progression. Background: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease that results in scarring of the lungs...
Published: 7/17/2025   |   Inventor(s): Grace Hyun Kim, Jonathan Goldin
Keywords(s): CT, Diagnostic Markers & Platforms, Inflammatory Diseases, Life Science Research Tools, Medical Imaging, Microscopy And Imaging
Category(s): Life Science Research Tools > Microscopy And Imaging, Medical Devices > Medical Imaging > CT, Therapeutics > Inflammation And Inflammatory Diseases
2019-468 PERIODONTAL MICROPATCH AND USES THEREOF
INTRODUCTION:UCLA researchers in the Departments of Bioengineering and Dentistry have developed a patch-based drug delivery system for dental applications.BACKGROUND:Periodontitis is a chronic inflammatory disease that affects tissues surrounding the teeth, and it is estimated that 50% of the U.S. population suffers from some type of periodontal disease....
Published: 7/17/2025   |   Inventor(s):  
Keywords(s): Dental, Drug Delivery, Inflammatory Diseases, Medical Devices and Materials, Other Polymers
Category(s): Platforms > Drug Delivery > Other Polymers
2016-518: Inhibition of Protein Tyrosine Phosphatase-Sigma for Hematopoietic Regeneration
Inhibition Of Protein Tyrosine Phosphatase - Sigma For Hematopoietic RegenerationSUMMARYUCLA Researchers have identified a novel pharmacological target for hematopoietic stem cell regeneration. They have developed small molecule inhibitors against the target and shown that the inhibitors cause rapid stem cell regeneration.BACKGROUNDDepletion of white...
Published: 7/17/2025   |   Inventor(s): John Chute, Michael Jung, Emelyne Diers
Keywords(s): Autoimmune, Hematology, Inflammatory Diseases, iPS/stem cells, Oncology
Category(s): Therapeutics > Autoimmune, Therapeutics > Oncology, Therapeutics > Hematology, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Stem Cells And Regenerative Medicine > Ips Stem Cells
2018-388 METABOLIC REQUIREMENTS FOR ALTERNATIVE MACROPHAGE ACTIVATION
Metabolic Requirements for Alternative Macrophage ActivationSUMMARYUCLA researchers in the Department of Molecular and Medical Pharmacology have discovered that Coenzyme A is a targetable requirement for anti-inflammatory macrophage differentiation.BACKGROUNDA dysregulated immune response is a hallmark of many disease phenotypes. For instance, cancer...
Published: 7/17/2025   |   Inventor(s): Steven Bensinger, Ajit Divakaruni, Anne Murphy, Wei Yuan Hsieh
Keywords(s): Autoimmune, Drug Delivery, Infectious Diseases, Inflammatory Diseases, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Autoimmune, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases
2018-159 Therapeutic Approach to Prevent or Alleviate Drug-, Noise- and Age-Related Hearing Loss
Therapeutic Approach To Prevent Or Alleviate Drug-, Noise- And Age-Related Hearing LossSUMMARYUCLA researchers in the Department of Head and Neck Surgery have developed a novel therapeutic approach to treating hearing loss using inflammation-resolving molecules.BACKGROUNDMore than 350 million people worldwide exhibit some degree of hearing loss, with...
Published: 7/17/2025   |   Inventor(s): Jennifer Long, Federico Kalinec
Keywords(s): Drug Delivery, Inflammatory Diseases, Nanoparticles, Therapeutics & Vaccines
Category(s): Platforms > Drug Delivery, Therapeutics, Therapeutics > Inflammation And Inflammatory Diseases, Platforms > Drug Delivery > Nanoparticles
A Novel Method To Enhance Tg6f Amelioration Of Dyslipidemia
SummaryUCLA researchers in the Department of Medicine have developed a novel protocol that enhances the effects of Tg6F in treating dyslipidemia.BackgroundDyslipidemia is characterized as having abnormal levels of cholesterol or triglycerides in the blood, resulting in an imbalance of circulating lipids. Patients with dyslipidemia tend to have a higher...
Published: 7/17/2025   |   Inventor(s): Alan Fogelman, Srinivasa Reddy, Mohamad Navab
Keywords(s): Cardiovascular, Inflammatory Diseases, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > Cardiovascular, Therapeutics > Inflammation And Inflammatory Diseases
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