Search Results - medical+therapeutics+gene+therapy

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Drugs That Regulate Heparan Sulfate Expression for Cancer Treatment
­Advantages: Developed a novel assay for identifying repurposed drugs targeting HS-related gene expression Revealed a dose-dependent inhibition of the HS-related gene EXT1 with Vitamin D/ Calcitriol EXT1 stable cell line with luciferase reporter ensures specificity in identifying EXT1 regulators, minimizing off-target effects Summary: Heparan...
Published: 9/3/2024   |   Inventor(s): Lianchun Wang
Keywords(s): Biotechnology, Cancer Treatment, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Localized In Vivo Electro Gene Therapy for Type 1 Diabetes
­Advantages: Novel gene therapy for Type 1 Diabetes (T1D) focused on reprogramming skeletal muscle cells to modulate glucose levels in vivo. Nano plasmid DNA of insulin and glucokinase decreased glucose levels in vitro and in vivo and enhanced insulin expression and secretion. Groundbreaking treatment for long-lasting blood glucose control...
Published: 7/2/2024   |   Inventor(s): Anna Bulysheva
Keywords(s): Diabetes, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Biotechnology
Secreted UBE3A for the Treatment of Neurological Disorders
­Advantages: Novel vector, composition, and method of treating a neurological disorder with UBE3A deficiency. High fidelity to human Angelman syndrome. Facilitates comprehensive symptom representation for diverse treatment investigations. Allows innovative experiments for pioneering treatment development. Summary: Angelman...
Published: 1/2/2024   |   Inventor(s): Kevin Nash
Keywords(s): Animal Models, Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience
Investigating the Role of BIN1's SH3 Domain in Alzheimer's Desease
­Advantages: The approach of targeting BIN1, a gene associated with AD increases the likelihood of finding effective therapeutic interventions. Determining the crystal structure of BIN1's SH3 domain provides detailed structural information which is crucial for designing small molecule inhibitors. The research reports promising preliminary...
Published: 1/23/2024   |   Inventor(s): Gopal Thinakaran
Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases, Neuroscience, Small Molecules
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Medical Diagnostics
Short Nuclear Repeat Element (SINE) RNA of Imprinted MicroRNA Clusters Mediate the Intrinsic, Type III Interferon-driven Viral Resistance of Hemochorial Placentas
­Advantages: Enhanced understanding of improved prenatal protection: Discovered a novel mechanism by which SINE RNA mediate intrinsic antiviral resistance in the placenta Opens the door to therapeutic intervention Summary: Addressing a fundamental challenge in prenatal health, this research investigates how the placenta at the maternal-fetal...
Published: 9/26/2023   |   Inventor(s): Hana Totary-Jain
Keywords(s): Medical Therapeutics Gene Therapy, Women’s Health
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Womens Health
Methods for Treating Symptoms of Kabuki Syndrome
­Advantages: Precision Control: Exogenous βHB enables precise and controlled administration, ensuring consistent and predictable βHB levels for tailored therapies. Easy Administration: It simplifies treatment compared to the ketogenic diet, particularly beneficial for pediatric patients and practical clinical use. Sustained Impact:...
Published: 2/6/2024   |   Inventor(s): Dominic D'Agostino, Sara Moss, Angela Poff
Keywords(s): Medical Therapeutics Gene Therapy, Therapeutics
Category(s): Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Therapeutics
RNA Aptamer Targeting of ADAM8 in the Tumor Microenvironment
­Advantages: Novel targeted RNA aptamers to inhibit ADAM8 and block cancer associated fibroblast maintenance in the tumor microenvironment. RNA aptamer benefits: high affinity, high specificity, and low immunogenicity Promising preclinical in vitro and in vivo outcomes Summary: This research delves into the intricate dynamics of cancer progression,...
Published: 5/20/2024   |   Inventor(s): Paul Kuo, Zhiyong Mi
Keywords(s): Cancer Treatment, Medical Therapeutics Cell Therapy, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Oncology, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Cell & Tissue Engineering
Novel small molecule targeting lncRNA in neurodegenerative diseases and tauopathies
­Advantages: Developed lead compound #67 to elevate GAS5 levels and also enhances neuronal insulin signaling, offering a comprehensive approach to neurodegenerative complexities. Noninvasive Insights: GAS5's presence as a serum biomarker enables noninvasive disease assessment and NPC86 treatment efficacy confirmation. Compound #67's...
Published: 3/14/2024   |   Inventor(s): Niketa Patel, Jianfeng Cai
Keywords(s): Medical Therapeutics Gene Therapy, Neurodegenerative Diseases
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Neuroscience
Novel FOXO1 Inhibitor for the Restoration of Lymphatic Valve Growth in Congenital Lymphedema
­Advantages: Foxo1 inhibitor increased the expression levels of valve-forming genes in vitro and valves in vivo MOA: Foxo1 inhibition increases β-catenin and activates downstream genes FOXO1 inhibition can be a viable strategy to rescue valve defects in congenital lymphedema Summary: Mutations in many genes that regulate lymphatic...
Published: 9/3/2024   |   Inventor(s): Ying Yang
Keywords(s): Genetics, Immunology, Medical Therapeutics Gene Therapy
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Biotechnology
Biomarker for Chronic Lung Disease: N-Myc-Interactor (NMI)
Competitive Advantages NMI Diagnostic Biomarker: predicting chronic lung allograft dysfunction (CLAD) in lung transplant patients NMI as a novel therapeutic target, to increase its expression in chronic lung disease Summary Lung transplant remains the primary treatment option for patients with advanced lung disease or irreversible pulmonary failure....
Published: 5/20/2024   |   Inventor(s): Nirmal Sharma, Mudassir Banday, Andreas Seyfang
Keywords(s): Biomarker, Cancer Treatment Lung Cancer, Medical Diagnostics, Medical Therapeutics Gene Therapy, Therapeutics
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical