Search Results - ad+-+alzheimer%e2%80%99s+disease

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Inhibitors of MNK Kinase for Targeted Cancer and CNS Therapeutics.
NU 2015-098 (NU 2015-098, NU 2018-036, NU 2025-036) INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* SHORT DESCRIPTION MNK kinase inhibitors that reduce cancer cell viability and proliferation and penetrates the brain for potential treatment of glioblastoma and CNS disorders. BACKGROUND Leukemia and brain...
Published: 4/30/2026   |   Updated: 4/29/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, AML - Acute myeloid leukemia, ASD - Autism Spectrum Disorder, Bladder cancer, Brain cancer, Breast cancer, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Lung cancer, Neurodegenerative disease, Pancreatic cancer, Prostate cancer, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment
SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU 2025-212 IP...
Published: 4/29/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Bladder cancer, Brain cancer, Breast cancer, Cancer Treatment, Cancer/Oncology, Cervical cancer, CNS - Central Nervous System, Colon cancer, Drug delivery, Endometrial cancer, Gastric cancer, GBM - Glioblastoma, Head and neck cancer, Immunology, Immunotherapy, Liver cancer, Lung cancer, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, Ovarian cancer, Pancreatic cancer, PD - Parkinson's Disease, Prostate cancer, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets
SHORT DESCRIPTION A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets. INVENTORS Shana Kelley* Weinberg College of Arts & Sciences, Department of Chemistry Yi Li * Principal Investigator NU 2025-050 IP STATUS PCT...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention
PROPOSED TITLE (cut & paste into Alternate Title): Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention NU 2023-007 SHORT DESCRIPTION A small molecule based approach that mitigates Alzheimer's neurodegeneration by inhibiting neuronal nitric oxide synthase to prevent tau phosphorylation and reduce Aβ oligomer formation. INVENTORS Richard...
Published: 4/27/2026   |   Updated: 4/27/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Covalent inhibitor, Kinase Inhibitor, Neurodegenerative disease, Neurology, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Noninvasive brain-specific inhibition of bone morphogenetic protein signaling for the prevention of tauopathy
NU2025-330 INVENTORS John Kessler* Justin Geier Chian-Yu Peng SHORT DESCRIPTION This invention uses a noninvasive gene therapy approach to prevent and treat tauopathies, such as Alzheimer's disease and frontotemporal dementia, by inhibiting bone morphogenetic protein (BMP) specifically within the central nervous system. BACKGROUND Tauopathies...
Published: 3/27/2026   |   Updated: 3/26/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Gene therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098 Inventors Leonidas C. Platanias* Gary E. Schiltz Rama K. Mishra Short Description A small molecule to treat glioblastoma multiforme by blocking the Mnk pathway. Background Glioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed...
Published: 3/5/2026   |   Updated: 3/5/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Netrin-1 mimetic peptide amphiphiles
Netrin-1 Mimetic Peptide Amphiphile Assemblies NU 2024-174 INVENTORS Samuel Stupp* Cara Smith Zaida Alvarez Pinto SHORT DESCRIPTION Nanofiber-shaped supramolecular assemblies that mimic netrin-1 bioactivity to stimulate neurite growth and synaptic maturation for enhanced CNS regeneration. BACKGROUND Neurotrophic factors are essential for...
Published: 2/20/2026   |   Updated: 2/20/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, CNS - Central Nervous System, CVA - Cerebrovascular Accident, Nanomaterials, Nanotechnology, Neurodegenerative disease, Regenerative medicine, SCI - Spinal cord injury, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU 2024-154 INVENTORS Songi Han* Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Samuel Lobo Peter C. Ryffel Lokeswara Rao Potnuru Karen Tsay Chung-Ta Han SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau...
Published: 3/23/2026   |   Updated: 10/30/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Drug discovery, Drug screening, HD - Huntington's Disease, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Compositions and Methods for Treating Alzheimer’s Disease
2018-043 INVENTORS Sergio T. Ferreira Diana Jerusalinsky William L. Klein* SHORT DESCRIPTION A novel gene transfer approach for brain delivery of an antibody for Alzheimer’s disease treatment BACKGROUND Alzheimer’s disease, a progressive form of neurodegeneration that causes impairs memory and cognition, currently impacts over...
Published: 11/6/2025   |   Updated: 6/1/2023   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206 INVENTORS Joseph Mazzulli* Iva Stojkovska SHORT DESCRIPTION A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases BACKGROUND Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 12/16/2025   |   Updated: 5/23/2022   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, ALS - Amyotrophic Lateral Sclerosis, HD - Huntington's Disease, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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