Search Results - ad+-+alzheimer%e2%80%99s+disease

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TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU2024-139 INVENTORS Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Sam Lobo Peter C. Ryffel Songi Han* SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau fibrils. BACKGROUND A major hallmark of several neurodegenerative...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, CNS - Central Nervous System, Neurodegenerative disease, Neurology, Research tool, Synthetic biology
Category(s): Life Sciences > Therapeutics
Compositions and Methods for Treating Alzheimer’s Disease
2018-043 INVENTORS Sergio T. Ferreira Diana Jerusalinsky William L. Klein* SHORT DESCRIPTION A novel gene transfer approach for brain delivery of an antibody for Alzheimer’s disease treatment BACKGROUND Alzheimer’s disease, a progressive form of neurodegeneration that causes impairs memory and cognition, currently impacts over...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Combination Treatment to Reduce Pathological Proteins in Neurodegenerative and Lysosomal Storage Diseases
NU 2021-206 INVENTORS Joseph Mazzulli* Iva Stojkovska SHORT DESCRIPTION A small molecule combination treatment to improve lysosomal function in neurodegenerative and lysosomal storage diseases BACKGROUND Many neurodegenerative disorders are characterized by a collapse in proteostasis, as shown by the accumulation of insoluble protein aggregates...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Biomedical, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, Small molecule
Category(s): Life Sciences > Therapeutics
Deep Learning Structural Analysis Of Cerebral Cortex Predicts Features From MRI Data
NU 2020-152 INVENTORS Pierre Alain Besson S. Kathleen Bandt* SHORT DESCRIPTION Graph convolutional neural networks (gCNNs) successfully predict patient age and sex from T1-weighted brain surface MRI data. BACKGROUND As clinical image-based data sets grow in resolution and size, the promise of machine learning greatly expedites image classification...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Artificial Intelligence & Machine Learning, Computer software, CVA - Cerebrovascular Accident, Data processing/analysis, Image/Signal processing, Neurologic disease, PD - Parkinson's Disease
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Nanostructures for Diagnosis and Therapy of Alzheimer's Disease
NU 2009-169 Inventors Vinayak Dravid* Saurabh Sharma Kristen Viola William Klein* Short Description Novel magnetic nanostructures that recognize toxic beta-amyloid protein oligomers responsible for Alzheimer's disease progression Abstract Northwestern University researchers have developed a new magnetic nanostructure that can be used to detect and...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Biomarker, Devices, Diagnostics, Health IT, Medical device, Nanoparticle, Neurodegenerative disease, Neurologic disease, Research tool, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Tau-7: Monoclonal Antibody Specific for the C-Terminus of Tau
NU 2008-109InventorLester BinderShort DescriptionTau-7 is a mouse monoclonal antibody (mAb) that binds to the carboxy terminal region of human tau. AbstractResearcher Lester Binder has created a series of useful antibodies that are specific for the human tau protein. This particular antibody, Tau-7 mAb, is of the IgG1 isotype and would be useful to...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Antibody, Diagnostics, Imaging, Neurodegenerative disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Selective Human Sirtuin-2 Inhibitors, the Therapeutic Candidate for Huntington's Disease
NU 2012-145InventorsRichard Silverman*Hua WangMohammad KhanfarAleksey KazantsevShort DescriptionSelective human sirtuin-2 inhibitors for use in treating Huntington's diseaseAbstractNorthwestern researchers have discovered a new series of selective human sirtuin-2 inhibitors which show excellent neuronal protection in the Huntington's disease model....
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Stable, Potent Compounds to Selectively Inhibit Neuronal Nitric Oxide Production
NU 2011-053 Inventors Haitao Mark Ji Richard B. Silverman* He Huang Abstract Nitric oxide (NO) is a critical neurotransmitter. Overproduction of NO has been implicated in a variety of neurological diseases, including Parkinson's, Alzheimer's, and Huntington's, as well as neuronal damage occurring in stroke patients. Inhibitors of the enzyme...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, CVA - Cerebrovascular Accident, Neurologic disease, Neurology, PD - Parkinson's Disease, Research reagent, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
Tau-C3: Monoclonal Antibody Specific to Tau Truncated at Aspartic Acid
NU 2003-065 Inventor Lester Binder* Short Description Tau-C3, is a mouse monoclonal antibody (mAb) that binds to human tau truncated at aspartic acid 421 Abstract Researcher Lester Binder has created a series of useful antibodies that are specific for the human tau protein, pertinent to Alzheimer research. This particular antibody, Tau-C3,...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Antibody, Diagnostics, Neurodegenerative disease, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098InventorsLeonidas C. Platanias*Gary E. SchiltzRama K. MishraShort DescriptionA small molecule to treat glioblastoma multiforme by blocking the Mnk pathway. BackgroundGlioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed patients die...
Published: 7/9/2025   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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