Search Results - tpd+-+targeted+protein+degradation

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Compounds and methods for FBXW7-R465C-mediated protein degradation
NU 2024-224 INVENTORS Xiaoyu Zhang* Ananya Basu SHORT DESCRIPTION This invention describes novel heterobifunctional compounds that exploit a somatic mutant of the FBXW7 E3 ligase for targeted protein degradation. BACKGROUND Targeted protein degradation (TPD) is a powerful therapeutic strategy that harnesses the cell's natural machinery...
Published: 6/17/2026   |   Updated: 11/18/2025   |   Inventor(s):  
Keywords(s): AUTM26C1, BIO2026, Cancer/Oncology, PROTAC, Targeted therapy, Therapeutics, TPD - Targeted protein degradation
Category(s): Life Sciences > Therapeutics
Compounds and methods of identifying novel E3 ligases for targeted protein degradation
NU 2023-096 INVENTORS Ananya Angela Basu Xiaoyu Zhang* SHORT DESCRIPTION A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22 BACKGROUND Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...
Published: 6/17/2026   |   Updated: 3/29/2024   |   Inventor(s):  
Keywords(s): AUTM26C1, BIO2026, Drug discovery, Proteomics, Small molecule, Targeted therapy, Therapeutics, TPD - Targeted protein degradation
Category(s): Life Sciences > Therapeutics