Search Results - tpd+-+targeted+protein+degradation

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SHORT DESCRIPTION A novel first-in-class proteolysis targeting chimera (PROTAC) that selectively degrades CD73 to reverse tumor immune evasion and inhibit cancer progression. INVENTORS Bin Zhang* Northwestern University Feinberg School of Medicine, Department of Medicine (Hematology & Oncology) Gary Schiltz* Weinberg...

Published: 7/6/2026 | Updated: 7/6/2026 | Inventor(s):

Keywords(s): BIO2026, Breast cancer, Cancer/Oncology, Colon cancer, Lung cancer, Melanoma, PROTAC, Targeted therapy, Therapeutics, TPD - Targeted protein degradation

Category(s): Life Sciences > Therapeutics

Inhibitors of MNK Kinase for Targeted Cancer and CNS Therapeutics

NU 2015-098B (NU 2015-098, NU 2018-036, NU 2025-036) INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* SHORT DESCRIPTION MNK kinase inhibitors that reduce cancer cell viability and proliferation and penetrates the brain for potential treatment of glioblastoma and CNS disorders. BACKGROUND Leukemia and brain...

Published: 7/2/2026 | Updated: 4/29/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, AML - Acute myeloid leukemia, ASD - Autism Spectrum Disorder, BIO2026, Bladder cancer, Brain cancer, Breast cancer, Cancer/Oncology, CNS - Central Nervous System, Colon cancer, Lung cancer, Neurodegenerative disease, Pancreatic cancer, Prostate cancer, Small molecule, Targeted therapy, Therapeutics, TPD - Targeted protein degradation

Category(s): Life Sciences > Therapeutics

Compounds and methods for FBXW7-R465C-mediated protein degradation

NU 2024-224 INVENTORS Xiaoyu Zhang* Ananya Basu SHORT DESCRIPTION This invention describes novel heterobifunctional compounds that exploit a somatic mutant of the FBXW7 E3 ligase for targeted protein degradation. BACKGROUND Targeted protein degradation (TPD) is a powerful therapeutic strategy that harnesses the cell's natural machinery...

Published: 6/17/2026 | Updated: 11/18/2025 | Inventor(s):

Keywords(s): AUTM26C1, BIO2026, Cancer/Oncology, PROTAC, Targeted therapy, Therapeutics, TPD - Targeted protein degradation

Category(s): Life Sciences > Therapeutics

Compounds and methods of identifying novel E3 ligases for targeted protein degradation

NU 2023-096 INVENTORS Ananya Angela Basu Xiaoyu Zhang* SHORT DESCRIPTION A CRISPR-activation screen for discovering E3 ligases amenable to targeted protein degradation, and a novel PROTAC for FBXO22 BACKGROUND Traditional small molecule drugs function by directly interfering with the activities of proteins. However, many proteins lack suitable...

Published: 6/17/2026 | Updated: 3/29/2024 | Inventor(s):

Keywords(s): AUTM26C1, BIO2026, Drug discovery, Proteomics, Small molecule, Targeted therapy, Therapeutics, TPD - Targeted protein degradation

Category(s): Life Sciences > Therapeutics