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Search Results - covalent+inhibitor
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Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention
PROPOSED TITLE (cut & paste into Alternate Title): Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention NU 2023-007 SHORT DESCRIPTION A small molecule based approach that mitigates Alzheimer's neurodegeneration by inhibiting neuronal nitric oxide synthase to prevent tau phosphorylation and reduce Aβ oligomer formation. INVENTORS Richard...
Published: 4/27/2026
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Updated: 4/27/2026
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Inventor(s):
Keywords(s):
AD - Alzheimer’s Disease
,
Covalent inhibitor
,
Kinase Inhibitor
,
Neurodegenerative disease
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Neurology
,
nNOS
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Small molecule
,
Targeted therapy
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Therapeutics
Category(s):
Life Sciences > Therapeutics
Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION
Covalent inhibitor
s and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy. INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* Jindan...
Published: 5/6/2026
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Updated: 3/5/2026
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Inventor(s):
Keywords(s):
AUTM26C1
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BIAUTM1
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Bladder cancer
,
Breast cancer
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Cancer/Oncology
,
Covalent inhibitor
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Lymphoma
,
Melanoma
,
PreSeed/Seed
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Prostate cancer
,
PROTAC
,
Small molecule
,
Targeted protein degradation
,
Targeted therapy
,
Therapeutics
Category(s):
Life Sciences > Therapeutics