Search Results - single-cell

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SINGLE-CELL EPIGENOMIC PROFILING USING DROPLET FLUIDICS AND CHEMICALLY MODIFIED HYDROGELS
SINGLE-CELL EPIGENOMIC PROFILING USING DROPLET FLUIDICS AND CHEMICALLY MODIFIED HYDROGELS Researchers at UCSF have developed materials and methods for high throughput single cell epigenomic sequencing using a capture/profiling approach with hydrogel scaffolds, thus facilitating a scale and form of epigenomic profiling beyond what has been previously...
Published: 7/6/2023   |   Inventor(s): Adam Abate, Xiangpeng Li
Keywords(s): DNA Capture, Droplet, Epigenomic, High-Throughput, Hydrogel, Microfluidic, Single-Cell
Category(s): Technology Classifications > Biology
PARTITIONING CELLS FOR HIGH-THROUGHPUT SINGLE-CELL SEQUENCING
PARTITIONING CELLS FOR HIGH-THROUGHPUT SINGLE-CELL SEQUENCING Researchers at UCSF have developed a method for high throughput single-cell multi-omic sequencing that is rapid, simple to operate, and offers key innovations over existing technologies. Single-cell sequencing technologies refer to the methods to obtain genomics, transcriptomics or multi-omics...
Published: 4/20/2023   |   Inventor(s): Adam Abate, Xiangpeng Li, Benjamin Demaree
Keywords(s): Genomic DNA, Hydrogel, Microfluidic, Partitioning, Sequencing, Single-Cell, Transcriptomics
Category(s): Technology Classifications > Biology
Genome Wide DNase I Hypersensitive Sites Detection in Formalin-Fixed Paraffin-Embedded Single Cells
A method of detecting DNase I hypersensitive sites ((DHS) in a single cell or very small number of cells, including cells recovered from formalin-fixed paraffin-embedded (FFPE) tissue slides of patient samples. DHS has revealed a large number of potential regulatory elements for transcriptional regulation in various cell types. The application of...
Published: 4/8/2024   |   Inventor(s): Qingsong Tang, Keji Zhao
Keywords(s): amplification, AMPLIFICATION-BASED, assay, CHROMATIN, DNase-Seq, Listed LPM Contreras as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Single-cell, TECHNIQUE, VCXXXX, WBXXXX, WIXXXX, XGXXXX, XHXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Diagnostics, Application > Research Materials
Model Cell Lines With and Without AKT1 Mutations Derived from Proteus Syndrome Patients
The Proteus syndrome is a congenital disorder characterized by patchy overgrowth and hyperplasia (cell proliferation) of multiple tissues and organs, along with susceptibility to developing tumors. It is a rare disorder, with incidence of less than one case per million, caused by a somatic mutation. It is also a mosaic disorder, that is one in which...
Published: 10/28/2024   |   Inventor(s): Marjorie Lindhurst, Leslie Biesecker
Keywords(s): CC3AXX, CCXXXX, CXXXXX, DERIVED, Lines, Patients, Proteus, Single-cell, Syndrome
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Research Materials