Search Results - pathogen

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Novel Safe Potent Single Vector Platform Vaccines Against Melioidosis (UCLA Case No. 2023-119)
UCLA researchers in the School of Medicine have developed a novel single-vector platform vaccine for preventing melioidosis, an infection caused by Burkholderia pseudomallei. BACKGROUND: Melioidosis, also known as Whitmore’s disease, is an infectious disease that can infect both humans and animals. The bacterium Burkholderia pseudomallei (Bp)...
Published: 2/21/2024   |   Inventor(s): Marcus Horwitz
Keywords(s): Burkholderia pseudomallei, Intracellular Pathogens, Live attenuated vaccine, Melioidosis, Pathogen, Select Agents, Tier 1 Diseases, Vaccines
Category(s): Therapeutics > Infectious Diseases
Swabseq Agnostic Diagnostic Platform (Case No. 2023-293)
Summary: UCLA researchers in the Departments of Computer Science and Anatomic Pathology have developed an untargeted NGS diagnostic tool capable of detecting all known and emerging respiratory RNA viruses in a single test, enhancing our capacity to rapidly address public health crises through improved diagnostics. Background: Most clinical diagnostic...
Published: 9/17/2024   |   Inventor(s): Eleazar Eskin, Valerie Arboleda
Keywords(s): agnostic detection, Bioinformatics, bioinformatics pipeline, Computer-Aided Diagnosis, Diagnostic Markers & Platforms, Diagnostic Test, DNA Sequencing, Medical diagnostics, metagenomic diagnostic platform, meta-genomics, next generation sequencing (NGS), Pathogen, Pathogenesis, Sequencing
Category(s): Platforms, Platforms > Diagnostic Platform Technologies, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Software & Algorithms, Software & Algorithms > Digital Health, Software & Algorithms > Bioinformatics
LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS
LOWER RESPIRATORY TRACT INFECTION DIAGNOSTICS Researchers at UCSF, CZ Biohub SF, CZI and University of Colorado have developed a host/pathogen classifier to differentiate patients with lower respiratory tract infections (LRTI) from those with non-infectious acute respiratory illnesses. Lower respiratory tract infections (LRTI) are a leading cause...
Published: 5/18/2023   |   Inventor(s): Charles (Chaz) Langelier, Peter Mourani, John Kamm, Eran Mick, Alexandra Tsitsiklis, Katrina Kalantar, Lilliam Ambroggio, Joseph DeRisi
Keywords(s): Disease Classifier, Pathogen, Respiratory
Category(s): Technology Classifications > Biology
Detection and Differentiation of Pathogenic Fungi in Clinical Samples Using a Multi-Analyte Profiling System
This invention provides a rapid, sensitive and specific diagnostic tool for the detection of pathogenic fungi and subsequent species-specific discrimination. CDC scientists have developed nucleic acid probes to identify the six most medically important Candida species and endemic mycoses, and to differentiate them from other medically important fungi...
Published: 7/25/2024   |   Inventor(s): Sanchita Das, Teresa Brown, Brian Holloway, Christine Morrison
Keywords(s): Bead, Beads, CANDIDA, CDC Docket Import, CDC Docket Import CDC Prosecuting, Clinical, Clinical SAMPLE, Compositions, DA1XXX, DAXXXX, Detection, Diagnose, Diagnosis, diagnostic, Diagnostic assay, Discriminate, discrimination, DXXXXX, FUNGAL, FUNGI, fungus, Methods, microarray, Nucleic, nucleic acid, OID-NCEZID-DFWED, PATHOGEN, PATHOGENIC, Probe, Species, VKXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, XEXXXX, XHXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Occupational Safety and Health, Application > Diagnostics, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease, ResearchProducts > Research Equipment
Nucleic Acid Detection of the Fungal Pathogen Histoplasma capsulatum from Clinical and Environmental Samples
This invention relates to detecting Histoplasma capsulatum by PCR using oligonucleotide probes specific for the fungus. Histoplasmosis is a mycotic infection of varying severity, usually localized in the lungs. Caused by H. capsulatum, infections are usually symptomatic but can develop into chronic disease, especially in immunocompromised individuals. Test...
Published: 7/25/2024   |   Inventor(s): Thomas Reid, Millie Schafer
Keywords(s): AA5XXX, AAXXXX, AIDS, assay, Avian, AXXXXX, CAPSULATUM, CDC, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA1XXX, DAXXXX, DETECTING, Detection, diagnostic, DXXXXX, FUNGAL, FUNGI, fungus, HISTOPLASMA, Histoplasmosis, HIV, Method, NESTED, NIOSH-DART, Nucleic, nucleic acid, NUCLEIC ACID DETECTION, PATHOGEN, PATHOGENIC, PATHOGENS, PCR, PCR ASSAY, RAPID, SENSITIVE, VKXXXX, VOXXXX, VPXXXX, WBXXXX, WCXXXX, WFXXXX, WGXXXX, WIXXXX, WMXXXX, XCXXXX, XEXXXX, XHXXXX, XIXXXX, YBXXXX, Zoo, Zoonotic
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, Application > Consumer Products, TherapeuticArea > Infectious Disease, TherapeuticArea > Dental, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Ophthalmology, Application > Occupational Safety and Health, Application > Therapeutics
Novel Targets to Prevent Borrelia burgdorferi Infection and Lyme Disease
B. burgdorferi-infected ticks can cause Lyme disease in mammalian hosts. This technology relates to the use of B. burgdorferi outer surface proteins (BBA64 and BBA66) as Lyme disease vaccine candidates. In vivo animal studies demonstrate these outer surface proteins inhibit tick-to-host B. burgdorferi transmission. Presently, there is no vaccine approved...
Published: 4/8/2024   |   Inventor(s): Robert Gilmore
Keywords(s): BBA66, BORRELIA, BURGDORFERI, CDC Docket Import, CDC Docket Import CDC Prosecuting, COMPONENT, DA3XXX, DAXXXX, DB3XXX, DBXXXX, DC4XXX, DXXXXX, Gene, Infectivity, MAMMALIAN, Necessary, PATHOGEN, TICK, TRANSMISSION, Vector, Via
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, Application > Diagnostics
Method of Enhancing Opsonophagocytosis
This invention aims to bolster the human body's own mechanisms to fight infection by enhancing an innate immune response, opsonophagocytosis. The specific 24 amino acid sequence (P4) acts as a polymorphonuclear cell activator. P4 can be administered in vivo along with a disease's specific antibody to enhance systemic bacterial clearance, thus leading...
Published: 7/25/2024   |   Inventor(s): GowriSankar Rajam, Sandra Steiner, George Carlone, Nikkol Atwell-Melnick Melnick, Jacquelyn Sampson, Joseph Martinez, Joseph Caba, Edwin Ades
Keywords(s): ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA3XXX, DAXXXX, DB3XXX, DB5XXX, DBXXXX, DC1XXX, DC4XXX, DCXXXX, DXXXXX, ENHANCING, Epitopes, FUNCTIONAL, Listed LPM Surabian as of 4/15/2015, Methods, OID-NCIRD-DBD, Opsonophagocytosis, PATHOGEN, PNEUMONIAE, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PsaA, RESPONSE, Streptococcus, THEREOF, USES
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease
Probe Set Global Optimization
Available for licensing and commercial development are methods to optimize sequence-based assays such as microarrays, multiplexed PCR or multiplexed antibody methods. This computational method uses numerical optimization to identify an optimal probe set to be used in an assay for the measurement of a specified set of targets. The method incorporates...
Published: 4/8/2024   |   Inventor(s): Kevin Brown, Eric Billings
Keywords(s): AA5XXX, AAXXXX, AC4XXX, ACXXXX, assay, AXXXXX, Bacterial, CA1AXX, CA1XXX, CAXXXX, computer methods, CXXXXX, DAXXXX, DXXXXX, Global, IAXXXX, IXXXXX, Nucleotide, OPTIMIZATION, PATHOGEN, Probe, probe set, Protein, SELECTION, Sequences, splice variants, VIRAL DIAGNOSTIC
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology
2019-737 Deep Learning-Based Color Holographic Microscopy
Summary: UCLA researchers in the Department of Electrical Engineering have developed a novel deep learning-based method that performs high-fidelity color image reconstruction using a single hologram. Background: Pathology slides are currently the gold standard in diagnostics for many diseases. Accurate color representations of well stained pathology...
Published: 7/19/2023   |   Inventor(s): Aydogan Ozcan, Yair Rivenson, Tairan Liu, Yibo Zhang, Zhensong Wei
Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Artificial Neural Network, Computer Aided Learning, Confocal Microscopy, Cytopathology, Digital Holography, Electron Microscope, Fluorescence Microscope, Fluorescence-Lifetime Imaging Microscopy Leading Lights, Histology, Histopathology, Holography, Image Resolution, Imaging, Immunohistochemistry, Machine Learning, Magnetic Resonance Imaging Pathology, Medical Imaging, Microscope, Microscopy, Microscopy And Imaging, Neuropathology, Pathogen, Pathogenesis, Pathophysiology, Perceptual Learning, Unsupervised Learning , Wavelength
Category(s): Electrical, Electrical > Imaging, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Diagnostic Markers, Medical Devices > Medical Imaging
Anti-Biofilm Compound 1 (ABC-1) and Associated Derivative Molecules
IntroductionBacteria commonly attach to living and nonliving surfaces in the form of biofilms. In this morphology, the bacteria synthesize a matrix of extracellular polymeric substances (EPS) that provide the biofilm with protection and structural support. The EPS also gives the biofilm resistance to antibiotics and immune system clearance, making biofilms...
Published: 11/21/2023   |   Inventor(s): Christopher Waters, Karthik Sambanthamoorthy, Matthew Neiditch, Martin Semmelhack
Keywords(s): Biofilm, Film, Pathogen
Category(s): Biotechnology