Search Results - nucleotide

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Potent Nucleotide Inhibitors of Ecto-5'-Nucleotidase (CD73)
These small molecules are novel nucleotide derivatives, containing either a purine or pyrimidine nucleobase, that competitively block the enzyme CD73, also known as ecto-5'-nucleotidase. This enzyme converts extracellular AMP (not a potent activator of adenosine receptors) to adenosine (the native activator of 4 subtypes of adenosine receptors. CD73...
Published: 7/25/2024   |   Inventor(s): Christa Mueller, Anna Junker, Kenneth Jacobson
Keywords(s): CB5EXX, CD73, Ecto-5-nucleotidase, Inhibitors, Nucleotide, POTENT
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Application > Therapeutics
Probe Set Global Optimization
Available for licensing and commercial development are methods to optimize sequence-based assays such as microarrays, multiplexed PCR or multiplexed antibody methods. This computational method uses numerical optimization to identify an optimal probe set to be used in an assay for the measurement of a specified set of targets. The method incorporates...
Published: 4/8/2024   |   Inventor(s): Kevin Brown, Eric Billings
Keywords(s): AA5XXX, AAXXXX, AC4XXX, ACXXXX, assay, AXXXXX, Bacterial, CA1AXX, CA1XXX, CAXXXX, computer methods, CXXXXX, DAXXXX, DXXXXX, Global, IAXXXX, IXXXXX, Nucleotide, OPTIMIZATION, PATHOGEN, Probe, probe set, Protein, SELECTION, Sequences, splice variants, VIRAL DIAGNOSTIC
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Infectious Disease, Application > Therapeutics, TherapeuticArea > Oncology
Development of Dengue Virus Type 3 Vaccine Candidates
The disease burden associated with dengue virus infection has increased over the past several decades in the tropical and semi-tropical regions of the world, where over 2 billion people live at risk of dengue infection. Annually, there are an estimated fifty (50) to one hundred (100) million cases of dengue fever, making development of an effective...
Published: 7/25/2024   |   Inventor(s): Joseph Blaney, Brian Murphy, Stephen Whitehead
Keywords(s): 1, 2, 3, 30, 3'-UTR, CANDIDATES, CONSISTING, Containing, Contiguous, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion, DELETIONS, Delta30, DEN4, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, Dervived, Development, DXXXXX, Either, Genome, Hepatitis A, Hepatitis D, Hepatitis E, Iin, MULTIPLE, Nucleotdies, Nucleotide, ONE, Q fever, Regions, THAN, TYPE, UAXXXX, UBXXXX, Vaccine, virus
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
Attenuated Human Parainfluenza Virus (PIV) for Use as Live, Attenuated Vaccines and as Vector Vaccines
The identified technologies describe self-replicating infectious recombinant paramyxoviruses with one or more attenuating mutations, such as a separate variant polynucleotide encoding a P protein and a separate monocistronic polynucleotide encoding a V protein, or at least one temperature sensitive mutation and one non-temperature sensitive mutation....
Published: 7/25/2024   |   Inventor(s): Peter Collins, Sheila Nolan, Mario Skiadopoulos, Brian Murphy
Keywords(s): cDNA, CIS-ACTING, Complete, DC5BXX, DC5XXX, DCXXXX, Determination, DXXXXX, FOR..., FRAMES, Gene, Generate, Generation, Genomic, HPIV2, HPIV2., HPIV2/V94, Identification, MEASLES, Mumps, MUTATION, Novel, Nucleotide, Overlapping, P/V, Parainfluenza virus type 3, Parainfluenza virus type 3; Human parainfluenza virus type 3, Reading, recombinant, rHPIV2, Separated, sequence, Strain, UA1XXX, USEFUL, V94
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines, TherapeuticArea > Infectious Disease
Dengue Tetravalent Vaccine Containing a Common 30 Nucleotide Deletion in the 3'-UTR of Dengue Types 1, 2, 3, and 4
The invention relates to a dengue virus tetravalent vaccine containing a common 30-nucleotide deletion (delta30) in the 3'-untranslated region (UTR) of the genome of dengue virus serotypes 1, 2, 3, and 4. The previously identified delta30 attenuating mutation, created in dengue virus type 4 (DEN4) by the removal of 30 nucleotides from the 3'-UTR, is...
Published: 7/25/2024   |   Inventor(s): Brian Murphy, Lewis Markoff, Barry Falgout, Kathryn Hanley, Joseph Blaney, Stephen Whitehead
Keywords(s): 3'-UTR, ANTIGENIC, chimeric, Chromosome 7, monosomy, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, Deletion, Deletion 7, DENGUE, Dengue (Flaviviridae), DXXXXX, Nucleotide, Tetravalent, UAXXXX, UBXXXX, Vaccine, Viruses
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines
2021-255 Benchmarking Computational Doublet-detection Methods For Single-cell RNA Sequencing Data
SUMMARY: UCLA researchers in the Department of Statistics have developed a software to compare existing doublet detection algorithms for Single-Cell RNA Sequencing Data. BACKGROUND: Single-cell RNA sequencing (scRNA-seq) provides the expression profiles of individual cells and is considered the gold standard for defining cell states and phenotypes...
Published: 7/19/2023   |   Inventor(s):  
Keywords(s): Algorithm, DNA Sequencing, Error Detection And Correction, Nucleotide, Polymorphism (Biology), RNA, RNA-Seq, Sequencing, Software, Software & Algorithms
Category(s): Software & Algorithms, Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Software & Algorithms > Programs
TUNABLE RNA INTERFERENCE VIA NUCLEOTIDE MISMATCH DESIGN
TUNABLE RNA INTERFERENCE VIA NUCLEOTIDE MISMATCH DESIGN Researchers at Stanford, the University of Massachusetts and the Chan Zuckerberg Biohub have developed methods to increase or decrease RNA interference target cleavage rates. Harnessing the power of RNA interference (RNAi), the biological process of RNA-guided and sequence-specific gene expression...
Published: 3/17/2023   |   Inventor(s): William Greenleaf, Phillip Zamore, Winston Becker, Benjamin Ober-Reynolds, Karina Jouravleva, Samson Jolly
Keywords(s): Gene Expression, miRNA, Nucleotide, RNAi, siRNA
Category(s): Technology Classifications > Biology