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The critical feature of this technology is the Evelyn-Rokitnicki-Abelseth (ERA) rabies whole genome DNA sequence. With the availability of the entire rabies genome, a recombinant vaccine can be developed using reverse genetics. Using this technology, CDC researchers have developed a recombinant, live-attenuated vaccine shown to confer protection against...

Published: 10/28/2024 | Inventor(s): Xianfu Wu, Charles Rupprecht

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Genome, Genomes, Method, OID-NCEZID-DHCPP, RELATED, Sequences, sequencing, viral, Whole

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines

Novel Recombinant Rabies Vaccine Also Capable of Immunocontraception

This invention relates to a recombinant, attenuated rabies vaccine that is also capable of inhibiting reproductive fertility. An Evelyn-Rokitnicki-Abelseth (ERA) rabies vaccine backbone, combined with a reproductive-specific protein, such as gonadotropin-releasing hormone (GnRH) or the sperm-binding zona-pellucida-glycoprotein-3 (ZP3) receptor, allows...

Published: 10/28/2024 | Inventor(s): Charles Rupprecht, Xianfu Wu

Keywords(s): AFXXXX, Agents, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DETECTING, DEXXXX, DXXXXX, IMMUNOCONTRACEPTIVE, Methods, OID-NCEZID-DHCPP, OID-NCIRD-DVD, PARECHOVIRUS, rabies, recombinant, VIRUS-BASED

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Diagnostics

Recombinant Pan-Lyssavirus for Use in Rabies and Broad-Lyssavirus Vaccination

CDC researchers have developed recombinant lyssaviruses that can be used for the development of an improved, broad-spectrum vaccine against several rabies genotypes. Lyssaviruses are single-stranded RNA viruses that cause rabies and rabies-like diseases in mammals. Currently, there are commercially available vaccines that are considered to be effective...

Published: 10/28/2024 | Inventor(s): Charles Rupprecht, Ivan Kuzmin, Xianfu Wu

Keywords(s): Against, CDC Docket Import, CDC Docket Import CDC Prosecuting, DB4XXX, DBXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, PAN-LYSSAVIRUS, rabies, vaccines

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines

The Combination of Curcumin and Vitamin B6 in the prevention of colorectal tumorigenesis and inflammation related to excess adiposity

SUMMARYTufts University investigator, Joel Mason and his team, has discovered a novel drug with Curcumin and Vitamin B6 that effectively alters pro-oncogenic inflammatory pathways trigged by obesity. This regimen has demonstrated the ability to significantly reduce tumor multiplicity and tumor burden in obese mice. PROBLEM Colorectal cancer (CRC) is...

Published: 9/30/2020 | Inventor(s): Joel Mason, Xian Wu

Keywords(s):

Category(s): Therapeutic