Search Results - charles+rupprecht

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Rabies Vaccine for the Oral Immunization of Domesticated Animals, Wildlife and Feral Animals
This invention, developed by the CDC and collaborators, entails a live, attenuated recombinant rabies virus vaccine that can elicit an effective anti-rabies immune response in animal recipients. Inoculation with a live, attenuated, rabies virus allows for the optimized production of immunity in the absence of pathogenicity. Oral administration of...
Published: 10/28/2024   |   Inventor(s): Charles Rupprecht
Keywords(s): CDC Docket Import, CDC Docket Import NP, DC5BXX, DC5XXX, DCXXXX, Dogs, DXXXXX, ENGINEERED, GENETICALLY, Immunization, rabies, recombinant, Stray, Vaccine, VLXXXX, VOXXXX, WFXXXX, Wildlife, WJXXXX, WMXXXX, XEXXXX, YBXXXX, YCXXXX
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Occupational Safety and Health, Application > Therapeutics, Application > Vaccines, Application > Consumer Products
Novel Live-Attenuated Rabies Vaccine
The critical feature of this technology is the Evelyn-Rokitnicki-Abelseth (ERA) rabies whole genome DNA sequence. With the availability of the entire rabies genome, a recombinant vaccine can be developed using reverse genetics. Using this technology, CDC researchers have developed a recombinant, live-attenuated vaccine shown to confer protection against...
Published: 10/28/2024   |   Inventor(s): Xianfu Wu, Charles Rupprecht
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Genome, Genomes, Method, OID-NCEZID-DHCPP, RELATED, Sequences, sequencing, viral, Whole
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines
Novel Recombinant Rabies Vaccine Also Capable of Immunocontraception
This invention relates to a recombinant, attenuated rabies vaccine that is also capable of inhibiting reproductive fertility. An Evelyn-Rokitnicki-Abelseth (ERA) rabies vaccine backbone, combined with a reproductive-specific protein, such as gonadotropin-releasing hormone (GnRH) or the sperm-binding zona-pellucida-glycoprotein-3 (ZP3) receptor, allows...
Published: 10/28/2024   |   Inventor(s): Charles Rupprecht, Xianfu Wu
Keywords(s): AFXXXX, Agents, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DETECTING, DEXXXX, DXXXXX, IMMUNOCONTRACEPTIVE, Methods, OID-NCEZID-DHCPP, OID-NCIRD-DVD, PARECHOVIRUS, rabies, recombinant, VIRUS-BASED
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines, Application > Diagnostics
Recombinant Pan-Lyssavirus for Use in Rabies and Broad-Lyssavirus Vaccination
CDC researchers have developed recombinant lyssaviruses that can be used for the development of an improved, broad-spectrum vaccine against several rabies genotypes. Lyssaviruses are single-stranded RNA viruses that cause rabies and rabies-like diseases in mammals. Currently, there are commercially available vaccines that are considered to be effective...
Published: 10/28/2024   |   Inventor(s): Charles Rupprecht, Ivan Kuzmin, Xianfu Wu
Keywords(s): Against, CDC Docket Import, CDC Docket Import CDC Prosecuting, DB4XXX, DBXXXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, PAN-LYSSAVIRUS, rabies, vaccines
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines
Antigen-capture Electrochemiluminescent Assay for Determining Rabies Vaccine Potency
CDC researchers developed a more efficient method of assessing rabies vaccine potency using an antigen-capture electrochemiluminescent (ECL) assay. This assay utilizes SULFO-NHS-Ester labeled murine monoclonal antibodies to quantify glycoprotein concentration, which is an indicator of vaccine potency. Currently, the potency of rabies vaccines is determined...
Published: 10/28/2024   |   Inventor(s): Charles Rupprecht
Keywords(s): AAXXXX, ABXXXX, AG1XXX, AG2XXX, AGXXXX, ANALYSES, assay, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, GLYCOPROTEIN, rabies, virus
Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Infectious Disease, Application > Vaccines
Isolated Lyssavirus Nucleic Acid and Protein Sequences
A novel strain in the rabies family of viruses, the Shimoni bat virus (SHIBV), has been discovered. Phylogenic and antigenic patterns identify SHIBV as a new species of Lyssavirus. Phylogenic reconstructions of SHIBV and monoclonal antibody typing were used to demonstrate a distinct genetic antigenic pattern. This unique genetic information may be used...
Published: 4/8/2024   |   Inventor(s): Wanda Markotter, Charles Rupprecht, Ivan Kuzmin
Keywords(s): Acid, CDC Docket Import, CDC Docket Import CDC Prosecuting, DA4BXX, DA4XXX, DAXXXX, DB4BXX, DB4XXX, DBXXXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, ISOLATED, Lyssavirus, Nucleic, Protein, Sequences
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Diagnostics, Application > Vaccines