Search Results - genome

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Compositions for Modification of Genomic DNA and Exogenous Gene Expression
A novel method of targeted insertion of transgenes at CLYBL locus directly in human cells is disclosed. Also, methods and compositions for increasing targeted insertion of a transgene into a specific location within the cell or increasing the frequency of gene modification in a targeted locus are disclosed. Genome modification by precise gene targeting...
Published: 7/30/2024   |   Inventor(s): Mahendra Rao, Jizhong Zou
Keywords(s): Cl, Compositions, GB2BXX, GB2CXX, Genome, Harbor, LOCUS, Methods, MODIFICATION, SAFE, Targeted, VEXXXX, WIXXXX, WJXXXX, XEXXXX, YAXXXX, YBL, YBXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Therapeutics, TherapeuticArea > Neurology
Novel Live-Attenuated Rabies Vaccine
The critical feature of this technology is the Evelyn-Rokitnicki-Abelseth (ERA) rabies whole genome DNA sequence. With the availability of the entire rabies genome, a recombinant vaccine can be developed using reverse genetics. Using this technology, CDC researchers have developed a recombinant, live-attenuated vaccine shown to confer protection against...
Published: 7/25/2024   |   Inventor(s): Xianfu Wu, Charles Rupprecht
Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, Compositions, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Genome, Genomes, Method, OID-NCEZID-DHCPP, RELATED, Sequences, sequencing, viral, Whole
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Vaccines
Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis
CDC researchers developed a simple target-specific isothermal nucleic acid amplification technique, termed Genome Exponential Amplification Reaction (GEAR). The method employs a set of four primers (two inner and two outer). The outer primer pair targets three specific nucleic acid sequences at a constant 60°C, while the inner pair of primers accelerates...
Published: 7/25/2024   |   Inventor(s): Prithiviraj Jothikumar, Vincent Hill, Jothikumar Narayanan
Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, Acids, ACXXXX, amplification, AMPLIFYING, AXXXXX, DA1XXX, DA2XXX, DA3XXX, DA4XXX, DA5XXX, DAXXXX, DXXXXX, Exponential, Gear, Genome, Isothermal, Methods, Nucleic, REACTION, REAGENTS, UBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Diagnostics
Development of Dengue Virus Type 3 Vaccine Candidates
The disease burden associated with dengue virus infection has increased over the past several decades in the tropical and semi-tropical regions of the world, where over 2 billion people live at risk of dengue infection. Annually, there are an estimated fifty (50) to one hundred (100) million cases of dengue fever, making development of an effective...
Published: 7/25/2024   |   Inventor(s): Joseph Blaney, Brian Murphy, Stephen Whitehead
Keywords(s): 1, 2, 3, 30, 3'-UTR, CANDIDATES, CONSISTING, Containing, Contiguous, DA4BXX, DA4XXX, DAXXXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, Deletion, DELETIONS, Delta30, DEN4, DENGUE, Dengue (Flaviviridae), DENGUE FEVER, Dervived, Development, DXXXXX, Either, Genome, Hepatitis A, Hepatitis D, Hepatitis E, Iin, MULTIPLE, Nucleotdies, Nucleotide, ONE, Q fever, Regions, THAN, TYPE, UAXXXX, UBXXXX, Vaccine, virus
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics, Application > Vaccines, TherapeuticArea > Infectious Disease
Construction of an Infectious Full-Length cDNA Clone of the Porcine Enteric Calicivirus RNA Genome
Porcine enteric calicivirus (PEC) is a member of the genus Sapovirus in the family Caliciviridae. This virus causes diarrheal illness in pigs, and is presently the only enteric calicivirus that can be grown in cell culture. In addition to its relevance to veterinary medicine as a diarrheal agent in pigs, PEC serves as an important model for the study...
Published: 7/25/2024   |   Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot, Kyeong-Ok Chang
Keywords(s): CALICIVIRUS, cDNA, CLONE, Construction, DA4BXX, DAXXXX, DB4BXX, DBXXXX, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENTERIC, FULL-LENGTH, Genome, INFECTIOUS, PORCINE, RNA
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Research Materials
Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins
The invention provides for a full-length cloned cDNA copy of the RNA genome of a predominant norovirus strain (Genogroup II.4) designated MD145-12 that was associated with human gastrointestinal illness. The noroviruses, which were formerly known as "Norwalk-like" viruses are estimated to cause 23 million cases of acute gastroenteritis in the USA each...
Published: 4/8/2024   |   Inventor(s): Stanislav Sosnovtsev, Lisbeth Kim Green, Gael Belliot
Keywords(s): Active, Biological, cDNA, CLONE, CONSENSUS, DC5BXX, DCXXXX, DDXXXX, DXXXXX, ENCODES, FULL-LENGTH, Genome, Human, MD145-12, Norovirus, proteins, Respresenting, RNA, sequence, Strain, That
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Research Materials
Reversible Microwells for Single Cells Culture and Recovery
INV-20077 Background Microwells are popular single cell-level culture platforms where small wells of tens of microns in size are able to hold only one cell or cell pairs according to the scope. Arrays of these wells are useful to separate cell populations and culture or image them. However, these wells are monolithic and normally engraved in the...
Published: 9/10/2024   |   Inventor(s): Giovanni Ugolini, Tania Konry
Keywords(s): Genome, Healthcare Innovation, Immunoengineering, Microarray, Microfluidics, Singe cell
Category(s): Technology Classifications > 1. Life Science > Bioengineering/Tissue Engineering
Man 1-2 Man-PEGylated Derivative as a Tool for in vitro and in vivo Dendritic Cell Targeting
INV-1151 Background The immune system (IS) has a delicate equilibrium between its cells. The most important cells of the IS are the B lymphocytes (BL), macrophages (MO), and dendritic cells (DC), so-called antigen presenting cells (APC). They are the key-linkers between the innate and the adaptive immunity, which is a crucial factor that will lead...
Published: 9/10/2024   |   Inventor(s): Vladimir Torchilin, Tatiana Levchenko, Juan Pappalardo, Stefano Salmaso, Micaela Toniutti
Keywords(s): Cancer, Chemistry, COVID, Drug Delivery, Genome, Health, Healthcare Innovation, Medical, Nanomedicine, Research Tool
Category(s): -Health, -Nanomedicine, -Cancer, Technology Classifications > 1. Life Science > Therapeutics, Technology Classifications > 1. Life Science > Drug Delivery