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Mice with humanized telomere homeostasis

Unmet Need: The imperative need for mouse models in advancing research on human aging and tumorigenesis Telomeres play a key role in human aging and tumorigenesis. However, studying telomeres in mouse models presents challenges due to significant difference in telomere length, which is up to 10 times longer than in humans. To address this limitation,...

Published: 10/8/2024 | Inventor(s): Jiyue Zhu, Shuwen Wang, Fan Zhang, De Cheng

Keywords(s): Animal Research, Biotechnology, Cancer and aging, Genome editing, Human Research, Male Infertility, Telomere and telomerase

Category(s): Technologies > Health & Well-being > Biotechnology

Masked-Based Learning Method for Neural Network Multiple Task Adaption

Nowadays, one practical limitation of deep neural networks (DNNs) is their high degree of specialization to a single task. This motivates researchers to develop algorithms that can adapt the DNN model to multiple tasks sequentially, while still performing well on past tasks. This process of gradually adapting the DNN model to learn from different...

Published: 4/19/2023 | Inventor(s): Deliang Fan, Fan Zhang, Li Yang

Keywords(s): Algorithm Development, Computational Machine, Computing Architecture, Cyber-Physical System, Machine Learning, Neural Computing

Category(s): Computing & Information Technology, Physical Science

Processing-In-Memory (PIM) Platform for mRNA Quantification

The study of human genetics is a rapidly expanding field, fueled in part by developments in large-scale protein and genomic sequencing technologies. Biopharmaceutical companies and modern healthcare rely heavily on sequencing technologies and the acquired data to develop new drugs and provide effective treatments to patients. However, the results...

Published: 2/23/2023 | Inventor(s): Deliang Fan, Fan Zhang, Shaahin Angizi

Keywords(s): Algorithm Development, Biomarker discovery, Computing Architecture, DNA and protein sequencing, Genomics, Proteomics, Sequencing

Category(s): Physical Science, Computing & Information Technology, Bioanalytical Assays, Chemistries & Devices, Genomic Assays/Reagents/Tools

Fast and Efficient Max/Min Searching in DRAM

In the era of big data, min/max searching from bulk data arrays is one of the most important and widely used fundamental operations in data-intensive applications such as sorting, ranking, bioinformatics, data mining, graph processing, and route planning. Online news and social media require real-time ranking using fast min/max searching from...

Published: 2/23/2023 | Inventor(s): Deliang Fan, Fan Zhang, Shaahin Angizi

Keywords(s): Algorithm Development, Computational Machine, Computing Architecture, Data Center, Data Mining, Microprocessors, Processing

Category(s): Computing & Information Technology, Physical Science

Method for 3D Nonlinear Structured Illumination Super-resolution Imaging

Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...

Published: 4/3/2023 | Inventor(s): Leilei Peng, Yu Li, Han Zhang

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry

Monolithic White and Multi-Color Lasers Tunable in Full Visible Spectrum

Semiconductor lasers able to emit over the full visible color spectrum have a wide range of practical applications such as solid-state lighting, full-color displays, visible color communications, and multi-color fluorescence sensing. To the human eye, light with a mixture of four monochromatic lasers is visually equivalent to a white illuminant. Current...

Published: 2/23/2023 | Inventor(s): Cun-Zheng Ning, Sunay Turkdogan, Zhicheng Liu, Fan Fan

Keywords(s): Materials and Electronics

Category(s): Advanced Materials/Nanotechnology, Chemical/Biological Sensors, Energy & Power, Imaging, Medical Imaging, Physical Science, Physics, Proteomic Assays/Reagents/Tools, Semiconductor Devices, Semiconductors, Materials & Processes