Search Results - diagnostic+markers+%3e+targets+and+assays

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NPEPPS Enhancers for Treating Tau-Induced Neurodegeneration (UCLA Case No. 2018-161)
UCLA researchers from the Department of Neurology have developed first-in-class small-molecule activators of NPEPPS that effectively lower pathological tau, offering a novel disease-modifying strategy for Alzheimer’s and other neurodegenerative disorders. BACKGROUND: Neurodegenerative dementias such as Alzheimer’s Disease (AD) and progressive...
Published: 10/22/2025   |   Inventor(s): Daniel Geschwind, Robert Damoiseaux, Liting Deng, Michael Jung, Jennifer Murphy, Gaoyuan Ma
Keywords(s):  
Category(s): Therapeutics > CNS and Neurology, Diagnostic Markers > Targets And Assays
Use of Blood, Bronchoalveolar Lavage Fluid (BALF) or Urine Cytokines Combined With Donor-Derived Cell-Free DNA (dd-cfDNA) as a Biomarker of Allograft (UCLA Case No. 2025-316)
UCLA researchers in the Department of Pulmonology have identified a novel non-invasive combinatorial biomarker for prediction, early detection, and monitoring of acute and chronic allograft injury. BACKGROUND: Post-surgery treatment and rejection surveillance for solid organ transplantation remains challenging, primarily due to a limited ability to...
Published: 10/3/2025   |   Inventor(s): Yusaku Shino
Keywords(s):  
Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Platforms > Diagnostic Platform Technologies
Antiviral Compounds Inhibiting Zika Virus (ZIKV), and Methods and Zika Treatment Thereof (UCLA Case No. 2025-241)
UCLA researchers from the Molecular and Medical Pharmacology Department and CNSI have identified antiviral compounds that effectively inhibit Zika virus infection and cytopathic effects, potentially leading to improved therapeutics and treatment outcomes. BACKGROUND: Zika virus (ZIKV), a flavivirus now endemic to several regions globally, can cause...
Published: 10/3/2025   |   Inventor(s): Vaithilingaraja Arumugaswami, Robert Damoiseaux
Keywords(s):  
Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Therapeutics > Infectious Diseases, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Platforms > Diagnostic Platform Technologies
Methods for Determining Drug-Target Structures by Combining Mass Spectrometry and Electron Diffraction (UCLA Case No. 2025-229)
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel approach to study protein-ligand interactions by integrating native mass spectrometry with electron diffraction. BACKGROUND: The accurate characterization of small molecule-protein interactions is crucial for biomedical research. High-throughput structural methods,...
Published: 10/29/2025   |   Inventor(s): Jose Rodriguez
Keywords(s):  
Category(s): Life Science Research Tools, Life Science Research Tools > Mass Spectrometry, Chemical > Synthesis, Chemical > Chemical Sensors, Chemical > Chemical Processing & Manufacturing, Chemical > Instrumentation & Analysis, Diagnostic Markers > Targets And Assays, Electrical > Sensors, Electrical > Instrumentation, Life Science Research Tools > Research Methods, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Screening Libraries, Life Science Research Tools > Lab Equipment, Mechanical > Sensors, Mechanical > Instrumentation, Optics & Photonics > Microscopy, Optics & Photonics > Spectroscopy
Self-Amplifying RNA Form of a Constitutively-Active Sting Protein for Enhancing T-Cell Response to Antigen-Presenting Cells (UCLA Case No. 2020-771)
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for delivering RNA to induce an immune response to cancer cells. BACKGROUND: Cancer therapy continues to remain a challenge despite improvements in detection and clinically available therapies. Recently, improvements to this field have been mainly in the...
Published: 10/22/2025   |   Inventor(s): William Gelbart
Keywords(s): Adenoviridae
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Diagnostic Markers > Targets And Assays
A Duplex Electrochemiluminescence Immunoassay for Total α-Synuclein and PS129-α-Synuclein (UCLA Case No. 2024-132)
Synucleinopathies are a group of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These diseases are characterized by the aggregation and deposition of α-synuclein (α-syn) in Lewy bodies (LBs) in PD and DLB or as glial cytoplasmic inclusions in MSA. In...
Published: 9/15/2025   |   Inventor(s): Gal Bitan
Keywords(s):  
Category(s): Diagnostic Markers > Targets And Assays, Therapeutics > CNS and Neurology
Subgraph Matching for High-Throughput DNA-Aptamer Secondary Structure Classification and Machine Learning Interpretability (Case No. 2025-104)
Intro Sentence: UCLA researchers in the Department of Mathematics have developed machine learning methods to rapidly identify novel aptamer sequences for target binding to accelerate highly-accurate diagnostic and therapeutic development. Background: Aptamers are single-stranded nucleotide polymers that bind with high affinity to targets such as...
Published: 8/19/2025   |   Inventor(s): Andrea Bertozzi, Anne Andrews, Matthew Tyler, Paolo Climaco, Noelle Mitchell
Keywords(s): Advanced Computing / AI, advanced computing methods, Aptamers, Artifical Intelligence (Machine Learning, Data Mining), artificial intelligence/machine learning models, bioinformatics pipeline, cancer target, clustering, computational efficiency, computational efficiency and analysis, design software, DNA clustering, DNA oligomer, DNA Sequencing, Drug, Drug Delivery, Drug Development, Drug Discovery, drug screening, high throughput, high throughput assays, high throughput testing, high-throughput analysis, High-Throughput Screening, interpretability, pipeline, large-scale parallelization, Machine Learning, machine learning modeling, motif structures, open source, open source code, OpenAI, Pharmaceutical Drug, protein classification, secondary structure, SELEX, sequences of interest, single strand DNA sequences, Software, Software & Algorithms, Software Development Tools, Software-enabled learning, subgraph matching, target binding, target detection, Targeted Therapy, Targets And Assays, tissue targeting accuracy
Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Data Analytics, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Screening Libraries, Platforms, Platforms > Drug Delivery, Diagnostic Markers > Targets And Assays, Diagnostic Markers, Software & Algorithms > Bioinformatics
A Diagnostic Epigenetic Score for Determining the Effect of Biomarkers for Asthma Drug Response (UCLA Case No. 2024-106)
UCLA researchers in the Department of Computational Medicine have developed a novel machine learning algorithm to generate an accurate molecular score for determining asthma drug response. BACKGROUND: Asthma is a globally prevalent, high-burden disease marked by substantial clinical heterogeneity and variable treatment response. This heterogeneity...
Published: 7/17/2025   |   Inventor(s): Elior Rahmani
Keywords(s):  
Category(s): Platforms > Diagnostic Platform Technologies, Diagnostic Markers > Targets And Assays, Software & Algorithms > AI Algorithms, Software & Algorithms > Digital Health, Therapeutics > Inflammation And Inflammatory Diseases
Saliva Anti-SSA/Ro IgA1 Differentiates Sjögren’s from Non-Sjögren’s Syndrome Patients (UCLA Case No. 2023-292)
UCLA researchers in the Department of Dentistry have developed a novel methodology to accurately differentiate patients with Sjögren’s Disease from non-Sjögren’s Disease patients by monitoring saliva IgA1 forms, enabling more accurate tracking of disease progression. BACKGROUND: The presence and detection of autoantibodies within...
Published: 7/17/2025   |   Inventor(s): David Wong
Keywords(s):  
Category(s): Therapeutics > Autoimmune, Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Therapeutics > Ophthalmology
Deep Learning-Enhanced Chemiluminescence Vertical Flow Assay for High-Sensitivity Cardiac Troponin I Testing (Case No. 2025-128)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering & Bioengineering have developed a novel, high-sensitivity chemiluminescence vertical flow assay for rapid cardiac diagnostics, addressing current challenges in both modern and underserved healthcare settings. Background: Point-of-care (POC) testing is performed...
Published: 10/17/2025   |   Inventor(s): Aydogan Ozcan, Gyeo-Re Han, Artem Goncharov, Hyouarm Joung, Dino Di Carlo, Merve Eryilmaz
Keywords(s):  
Category(s): Chemical, Chemical > Instrumentation & Analysis, Diagnostic Markers, Diagnostic Markers > Targets And Assays, Electrical, Electrical > Imaging, Software & Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Therapeutics, Therapeutics > Cardiovascular
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