Search Results - david+wong

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Physical Separation of Ultrashort Single-Stranded Cell-Free DNA in Biofluids Using Differential Filtration and Next-Generation Sequencing Pipeline to Detect Methylation Status of Ultrashort Single-Stranded Cell-Free DNA (UCLA 2023-077, 2023-082)

UCLA researchers in the Department of Dentistry have established novel extraction and bioinformatics pipeline of ultrashort single-stranded cell-free DNA for the use in liquid biopsy diagnostics. BACKGROUND: Liquid biopsy is a critical diagnostic tool for various human diseases. The rapid market growth of liquid biopsy is primarily driven by novel...

Published: 7/1/2024 | Inventor(s): David Wong

Keywords(s): Cancer, cell-free DNA, circulating DNA, Diagnostic Markers & Platforms, DNA methylation, liquid biopsy, next generation sequencing (NGS)

Category(s): Software & Algorithms > Bioinformatics, Life Science Research Tools > Research Methods, Platforms > Diagnostic Platform Technologies

Inhibitors of Transporters or Uptake of Monoaminergic Neurotransmitters

Background One form of medical treatment for depression and neuropathic pain features a dual inhibitor called Cymbalta. This drug is manufactured and marketed by Eli Lilly. Researchers at Oregon State University have discovered a very efficient way of synthesizing Synosutine, which is comparable to Cymbalta in limited in vitro and in vivo assay....

Published: 6/17/2024 | Inventor(s): James White, David Chan, David Wong, Rajan Juniku, Jongtae Yang

Keywords(s): Biomedical, pharmaceuticals

Category(s): Chemistry

2021-252: METHOD FOR DIAGNOSING DRY MOUTH USING BIOMARKERS

SUMMARY: UCLA researchers in the Department of Dentistry have developed a novel and simple method using saliva sampling to detect and monitor xerostomia by testing for the expression of targeted biomarkers. BACKGROUND: Xerostomia, or dry mouth, occurs when salivary glands do not produce enough saliva. Xerostomia ranges in severity from mild discomfort...

Published: 9/5/2023 | Inventor(s): David Wong

Keywords(s):

Category(s): Diagnostic Markers, Diagnostic Markers > Targets And Assays, Therapeutics > Dental

2018-149 Salivary extracellular RNA (exRNA) biomarkers for gingivitis

A team from the School of Dentistry and Department of Oral Biology at UCLA has created a non-invasive test to diagnose and track the progression of gingivitis.BACKGROUND:Gingivitis is one of the most prevalent inflammatory diseases in humans and is characterized by irritation and swelling of the gums. If left unchecked, gingivitis can lead to teeth...

Published: 7/19/2023 | Inventor(s): David Wong, Karolina Kaczor-Urbanowicz, Harsh Trivedi, James Masters

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Therapeutics > Dental

2013-794 SALIVARY IL8 AND SERUM FOR ORAL CAVITY AND OROPHARYNGEAL CANCER AND PROBE IMMOBILIZATION AND SIGNAL AMPLIFICATION FOR POLYMER-BASED BIOSENSOR

UCLA researchers in the Department of Dentistry have developed a method of using improved polymer-based biosensors to detect the presence of nucleic acids, proteins, and other analytes in bodily fluids such as saliva in order to diagnose diseases such as oral cancer.BACKGROUND: Highly sensitive and robust detection methodologies, specifically those...