Search Results - william+beltran

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Silencing of PRLΔE1 expression: a gene-agnostic treatment for retinal degenerations

Viral vector-mediated gene silencing of a novel short retinal isoform of Prolactin promotes photoreceptor survival. Problem: Age-related macular degeneration (AMD) and inherited retinal degeneration (IRDs) have extreme mutational heterogeneity, and many IRDs are orphan diseases. Developing individual gene therapies for each causative gene is impractical...

Published: 7/2/2024 | Inventor(s): William Beltran, Raghavi Sudharsan

Keywords(s): Drug Target, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Ophthalmology, Orphan Disease

Category(s): Technology Classifications > Therapeutics

PennSorter: A software platform for rapid neural signal analysis.

PennSorter is a specialized "spike-sorting" software designed to facilitate the precise assignment of electrical signals to cells with enhanced accuracy and efficiency. Problem: Biomedical researchers, particularly those studying neurons and other electrically excitable cells like cardiac or muscle cells, frequently gather electrical data...

Published: 7/2/2024 | Inventor(s): William Beltran, Sergei Nikonov, Jean Bennett, Roman Nikonov, Puya Aravand

Keywords(s): Neurology, Software

Category(s): Technology Classifications > Research Tools & Reagents

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 7/30/2024 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

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Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

Gene Therapy for Leber Congenital Amaurosis Ciliopathy

AAV-mediated gene therapy approach for the treatment of Leber congenital amaurosis retinopathies resulting from NPHP5 mutations Problem: Leber congenital amaurosis (LCA) is an autosomal recessive disorder characterized by retinal dystrophy and severe visual impairment within the first year of life. LCA occurrence, while rare (1/50,000 – 1/33,000...

Published: 7/2/2024 | Inventor(s): Gustavo Aguirre, William Beltran, Samuel Jacobson, Artur Cideciyan

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Category(s): Technology Classifications > Therapeutics

Gene Therapy for the Treatment of Retinal Degeneration and Vision Loss

Recombinant adeno-associated virus (rAAV) expressing the gene for retinitis pigmentosa GTPAse regulation (RPGR) for the functional and structural rescue of photoreceptor cells of the eye as gene therapy for retinal degeneration and vision loss. Technology Overview: Retinitis pigmentosa (RP) is a genetic form of early-onset retinal degeneration that...

Published: 7/8/2024 | Inventor(s): William Beltran, Gustavo Aguirre, Artur Cideciyan, Samuel Jacobson

Keywords(s): Gene Therapy

Category(s): Technology Classifications > Animal Health, Technology Classifications > Therapeutics

Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers

Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...

Published: 4/3/2023 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert

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Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources

All-Fiber Multicore Fiber Laser Devices

Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...

Published: 4/3/2023 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources