Search Results - ji-hyung+lee

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DNA Secondary Structure (G-quadruplex) Stabilizers Improve Muscle Repair in Acute Injuries, Exercise, and Aging
Essential stem cell maintenance genes, including Pax7, a transcription factor fundamental to preserving the high regenerative capacity of muscles, is induced via targeting DNA secondary structures. Problem: Tissue restoration is essential to maintain skeletal muscles after injury. Skeletal muscle regeneration is exclusively achieved by the bona fide...
Published: 6/13/2025   |   Inventor(s): Foteini Mourkioti, Ji-Hyung Lee
Keywords(s): Aging, Drug Target, Orthopedics, Regenerative Medicine, Small Molecule
Category(s): Technology Classifications > Therapeutics
Inhibition of T Cell Differentiation and Senescence by Overexpression of Transcription Factor c-Myb
Abstract: Adoptive Cell Therapy (ACT) is a promising technique that uses a patient's own T cells to treat cancer. The process requires removing and engineering a patient's T cells to express a chimeric antigen receptor (CAR) or T cell receptor (TCR) that targets a specific cancer antigen. When the modified T cells are reintroduced into the patient,...
Published: 4/22/2025   |   Inventor(s): Sanjivan Gautam, Yun Ji, Luca Gattinoni
Keywords(s): act, Adoptive Cell Transfer, CANCER, CAR, chimeric antigen receptor, Gattinoni, Immunotherapy, Infectious Disease, Stem Cell, T cell, T Cell Receptor, TCR
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Overexpression of Phf19 on T Cells Enhances Therapeutic Effects of T Cell-Based Therapies (such as Chimeric Antigen Receptor [CAR] Therapies)
Abstract: T cell-based immunotherapy (such as CAR therapies) is a promising approach for the treatment of several cancers. However, T cells currently employed for various T cell-based immunotherapies are usually senescent and terminally differentiated leading to poor proliferative and survival capacity, limiting their therapeutic effectiveness once...
Published: 4/22/2025   |   Inventor(s): Yun Ji, Luca Gattinoni
Keywords(s): CAR-T Therapy, CD8, chimeric antigen receptor, Gattinoni, Phf19, T cell
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit Endospores
Modified Green Tea Polyphenol EGCG and EGCG-ester Inhibit EndosporesResearchers at Augusta University have invented skin-friendly compositions and methods for killing, inactivating, or otherwise reducing the bacterial endospores by using an effective amount of the green tea EGCG or its derivatives. EGCG research shows clear application for a hand sanitizer...
Published: 4/21/2023   |   Inventor(s): Stephen Hsu, Lee Lee, Tin-Chun Chu
Keywords(s):  
Category(s): Therapeutics