Search Results - ophthalmology

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Intrastromal Lamellar Keratoprosthesis (Artificial Cornea) (Case No. 2025-177)
Summary: UCLA researchers in the Department of Ophthalmology have developed an intrastromal artificial cornea implant designed to enhance biointegration and effectively restore vision. Background: Corneal opacities are among the top five causes of blindness worldwide. For patients who are not candidates for conventional corneal transplantation, keratoprosthesis...
Published: 6/16/2025   |   Inventor(s): Seyed Reza Ghaffari Dehkharghani, Anthony Aldave
Keywords(s): Biologic Medical Product, Biomedical Engineering, biomedical implantation, biomedical sensors, diseases of the eye, eye disease, eye motion, eye movement disorders, Eye Surgery, eye tracking, Glaucoma, macular corneal dystrophy, Macular Degeneration, Medical Device, Medical Imaging Eyepiece, on-eyelid sensor, Ophthalmic antibiotics, Ophthalmology, Other Polymers, Polymers, Prosthetics, Transplant, Transplant Rejection, transplant surgery
Category(s): Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Ophthalmology
Design of Wireless Interrogated MEMS Capacitive Intraocular Pressure Sensors
Advantages Detects intraocular pressure changes with sub-0.1 mmHg resolution for superior clinical precision. Battery-free wireless design enables safe, continuous monitoring through inductive telemetry technology. Biocompatible materials ensure long-term implantation with minimal risk and high patient safety. MEMS-based fabrication allows cost-effective,...
Published: 6/3/2025   |   Inventor(s): Ramesh Ayyala, Liguan Li, Jing Wang
Keywords(s): Ophthalmic Equipment, Ophthalmology
Category(s): Technology Classifications > Medical > Ophthalmology
Drug Loading of Donor Corneas for Corneal Transplantation
Advantages Provides a preventative approach to improving vision and reducing post-procedure complications Does not compromise or change donor tissue quality or viability Can be accomplished with a variety of techniques available in the market Drug dose and release can be controlled to meet patient specific needs Summary Partial and full thickness...
Published: 5/28/2025   |   Inventor(s): Christopher Passaglia, Edgar Espana, Emily Checchio
Keywords(s): Ophthalmology, Organ Transplantation
Category(s): Technology Classifications > Medical > Surgery, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Therapeutics
Enlarging Attachment for Binocular Indirect Ophthalmoscopy
A retrofittable attachment that provides increased magnification of the back of the eye (the ocular fundus). Background: Indirect ophthalmoscopy is performed by an examiner with the use of a binocular indirect ophthalmoscope (BIO). The examiner uses a headset to view an image of the patient's eye in a condensing lens hand-held by the examiner...
Published: 5/13/2025   |   Inventor(s): David Krumholz
Keywords(s): #SUNYresearch, eye examination, fundus, imaging, medical devices, ophthalmology, ophthalmoscopy, retina, Technologies, vision care
Category(s): Technology Classifications > Imaging, Technology Classifications > Medical Devices, Campus > SUNY College of Optometry
Novel Potential Glaucoma Therapy via Secretome Treatment of Schlemm’s Canal Endothelial Cells
Advantages: Minimally invasive secretome therapy enhances Schlemm’s canal function, offering a non-surgical alternative to glaucoma treatment Secretome therapy promotes cellular repair and wound healing, addressing TM damage beyond Increased Intraocular Pressure (IOP) reduction Secretome therapy enhances aqueous outflow by upregulating tight...
Published: 4/17/2025   |   Inventor(s): Rong Du, Yiqin Du, Enzhi Yang
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical, Technology Classifications > Chemistry
Computerized Method to Quantitate Blurriness of Ocular Fundus Images
Advantages: A novel computerized system integrates entropy filtering and FFT-based scoring to enable automated, precise uveitis diagnosis A computerized method provides an objective, reproducible score for ocular inflammation, reducing subjectivity in clinical grading scales Utilize low pass filtering and image subtraction to highlight obscured...
Published: 6/4/2025   |   Inventor(s): Brian Madow, David Richards, Erin Greenberg, Christopher Passaglia
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Medical > Ophthalmology, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Data/AI > D/AI Imaging
A Smart-App, VR headset, Cloud and AI based Method to Detect Field of Vision Problems
Advantages: GlaucTest offers a cost-effective and accessible home test for the second leading cause of blindness worldwide The ease of testing and re-testing would increase the reliability and precision of tracking small changes that are otherwise difficult to capture Improved testing conditions will facilitate consistency and replicability Summary: Glaucoma,...
Published: 3/19/2025   |   Inventor(s): Ramesh Ayyala, Sriram Chellappan, John Musser, Ahsan Wahab
Keywords(s): Diagnostics, Ophthalmic Equipment, Ophthalmology
Category(s): zzDiagnostics, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Imaging, Technology Classifications > Medical > Ophthalmology
Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)
UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...
Published: 3/6/2025   |   Inventor(s): Xianjie Yang
Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology
Intravitreal Injection Device (Case No. 2024-136)
Summary: Researchers in the Department of Ophthalmology at UCLA have developed an intravitreal injection device for safer and more precise injections. Background: Intravitreal injections are vital for treating sight-threatening retinal conditions like age-related macular degeneration and diabetic macular edema. These conditions rely heavily on accurate...
Published: 2/28/2025   |   Inventor(s): Taras Gout, Robert Goldberg
Keywords(s): diseases of the eye, Eye Surgery, Macular Degeneration, Ophthalmic antibiotics, Ophthalmology
Category(s): Medical Devices > Surgical Tools, Therapeutics > Ophthalmology, Medical Devices > Hospital Systems
SLURP1 is a Novel Therapeutic Target for Ocular Surface Inflammatory Disorders
Advantages: Identification and validation of SLURP1 as a therapeutic target for treating ocular therapies SLURP1 enhances antioxidant defenses SLURP1 counteracts TGF-β-induced EMT in corneal epithelial cells Potential for Formulating eye care products with SLURP1 to mitigate oxidative stress and maintain corneal epithelial homeostasis (e.g....
Published: 5/1/2025   |   Inventor(s): Shivalingappa Swamynathan, Sudha Swamynathan, Satinder Kaur
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology
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