Search Results - ophthalmology

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Improving Diagnosis and Treatment of Sarcoidosis
Using a blood or tissue biomarker to improve diagnosis and identification of a new targeted treatment. Problem: Sarcoidosis is an inflammatory disease that can affect any organ, predominantly the lung, skin, and the lymphatic system. Symptoms include difficulty breathing, extreme fatigue, skin inflammation, and joint pain. Sarcoidosis compromises patients’...
Published: 12/5/2024   |   Inventor(s): Thomas Hin-Chai Leung, Satish Sati, Misha Rosenbach
Keywords(s): Dermatology, Immunology, Inflammation, Ophthalmology, Pulmonary
Category(s): Technology Classifications > Diagnostics
CHST6 Mini Gene - CHST6 Expression Construct With Native Promoter (UCLA Case No. 2023-301)
UCLA researchers from the Department of Human Genetics and Department of Ophthalmology have developed a mini gene encoding a protein which is mutated in macular corneal dystrophy, leading to a potential gene therapy for this disorder. BACKGROUND: Macular corneal dystrophy (MCD) is a rare genetic disease caused by mutations in the CHST6 gene, which...
Published: 11/22/2024   |   Inventor(s): Wenlin Zhang, Anthony Aldave
Keywords(s): AAV, Adeno-associated viruses (AAV), Gene Editing Systems, Gene Therapy, genetics, keratinocytes, macular corneal dystrophy, mini gene, mutation, native promoter, Ophthalmology
Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing
An Improved and Targeted Approach to Genetic Screening for Primary Open-Angle Glaucoma in African Ancestry Population
A method for more targeted pre-screening for Primary Open-Angle Glaucoma (POAG) in individuals of African ancestry. Problem: POAG, the leading cause of irreversible blindness worldwide, currently affects 44 million individuals globally and is expected to impact 80 million people by the year 2040. Of particular concern is its disproportionate burden...
Published: 10/16/2024   |   Inventor(s): Joan O'Brien, Marylyn Ritchie, Rebecca Salowe, Shefali Verma, Yuki Bradford
Keywords(s): Ophthalmology
Category(s): Technology Classifications > Diagnostics
Anti-Inflammatory Drug Eluting Patches for Treatment of Ocular Injuries (UCLA Case No. 2022-156)
UCLA researchers in Department of Chemical and Biomolecular Engineering developed a visible light crosslinkable hydrogel-based drug delivery platform that can achieve sustainable release of anti-inflammatory drug molecules to address unmet need of drug bioavailability in ocular injury treatment. BACKGROUND: The Centers for Disease Control and Prevention...
Published: 9/26/2024   |   Inventor(s): Nasim Annabi
Keywords(s): eye disease, gelpatch, hyaluronic acid, micelles, Nanoparticles, ocular, ocular inflammation, Ophthalmic antibiotics, Ophthalmology
Category(s): Therapeutics > Ophthalmology
Cutting Needle Holder (Case No. 2024-120)
Intro Sentence: Researchers from the UCLA Jules Stein Eye Institute have developed a novel multi-use surgical instrument for improved oculoplastic surgical outcomes. Background: Oculoplastic surgeries are very common in the United States, with approximately 325,000 blepharoplasties alone performed annually. Suturing during this procedure requires...
Published: 10/4/2024   |   Inventor(s): Taras Gout, Erin Napier, Robert Goldberg, Maria Quintero, Ethan Osias, Erica Wilson-Rapolla
Keywords(s): biomedical implantation, Invasiveness Of Surgical Procedures, Medical Device, Medical Devices and Materials, Ophthalmology, Preclinical surgical innovation, Surgical Instrument, surgical mesh, surgical oncology, Surgical Suture , surgical tool, Surgical Tools, wearable medical device, wearable medical devices
Category(s): Medical Devices, Medical Devices > Surgical Tools
System and Methods for Fluidic Control in Ophthalmic Procedures (Case No. 2024-229)
Summary: Researchers in the Mechanical Engineering Department at UCLA developed an innovative mechatronic system that can perform fast and accurate pressure regulation during cataract surgeries. Background: Despite being generally safe and successful, cataract surgery has a complication rate of about 6%, which is concerning given the high volume...
Published: 10/31/2024   |   Inventor(s): Tsu-Chin Tsao, Yu-Ting (Kevin) Lai, Aya Barzelay
Keywords(s): biomedical sensors, Intraocular Lens , Ophthalmology, Robotic Surgery
Category(s): Mechanical > Instrumentation, Medical Devices > Hospital Systems, Medical Devices > Surgical Tools, Medical Devices > Monitoring And Recording Systems, Therapeutics > Ophthalmology
Enlarging Attachment for Binocular Indirect Ophthalmoscopy
A retrofittable attachment that provides increased magnification of the back of the eye (the ocular fundus). Background: Indirect ophthalmoscopy is performed by an examiner with the use of a binocular indirect ophthalmoscope (BIO). The examiner uses a headset to view an image of the patient's eye in a condensing lens hand-held by the examiner...
Published: 11/26/2024   |   Inventor(s): David Krumholz
Keywords(s): #SUNYresearch, eye examination, fundus, imaging, medical devices, ophthalmology, ophthalmoscopy, retina, Technologies, vision care
Category(s): Technology Classifications > Imaging, Technology Classifications > Medical Devices, Campus > SUNY College of Optometry
Silencing of PRLΔE1 expression: a gene-agnostic treatment for retinal degenerations
Viral vector-mediated gene silencing of a novel short retinal isoform of Prolactin promotes photoreceptor survival. Problem: Age-related macular degeneration (AMD) and inherited retinal degeneration (IRDs) have extreme mutational heterogeneity, and many IRDs are orphan diseases. Developing individual gene therapies for each causative gene is impractical...
Published: 7/2/2024   |   Inventor(s): William Beltran, Raghavi Sudharsan
Keywords(s): Drug Target, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Ophthalmology, Orphan Disease
Category(s): Technology Classifications > Therapeutics
A Precise, Analytical Model to Measure Visual Function and Monitor Retinal Disease
A model to estimate the change in photoreceptor outer segment length that occurs upon light stimulation – a biomarker of cone function in the retina. Problem: Vision relies on the isomerization of photopigments within photoreceptors (cones and rods) by light. Traditionally, researchers and clinicians have relied on functional assessments of photoreceptor...
Published: 3/6/2024   |   Inventor(s): Jessica Morgan, David Brainard, Raymond Warner
Keywords(s): Neurology, Ophthalmology
Category(s): Technology Classifications > Imaging, Technology Classifications > Diagnostics, Technology Classifications > Testing & Measurement
mRNA Therapeutics for Corneal Endothelium Regeneration
A novel mRNA-based therapy that induces corneal endothelium regeneration to restore vision loss Problem: Corneal endothelial cells are critical for maintaining a clear cornea, mainly by pumping fluid out of the tissue. Decrease in number of these cells results in the clouding of the cornea that leads to vision loss. The standard of care for Fuchs Endothelial...
Published: 6/27/2024   |   Inventor(s): Panteleimon Rompolas
Keywords(s): Gene Therapy, Healthcare IT, Ophthalmology
Category(s): Technology Classifications > Therapeutics
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