Search Results - ophthalmology

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Enlarging Attachment for Binocular Indirect Ophthalmoscopy
A retrofittable attachment that provides increased magnification of the back of the eye (the ocular fundus). Background: Indirect ophthalmoscopy is performed by an examiner with the use of a binocular indirect ophthalmoscope (BIO). The examiner uses a headset to view an image of the patient's eye in a condensing lens hand-held by the examiner...
Published: 4/1/2025   |   Inventor(s): David Krumholz
Keywords(s): #SUNYresearch, eye examination, fundus, imaging, medical devices, ophthalmology, ophthalmoscopy, retina, Technologies, vision care
Category(s): Technology Classifications > Imaging, Technology Classifications > Medical Devices, Campus > SUNY College of Optometry
A Smart-App, VR headset, Cloud and AI based Method to Detect Field of Vision Problems
Advantages: GlaucTest offers a cost-effective and accessible home test for the second leading cause of blindness worldwide The ease of testing and re-testing would increase the reliability and precision of tracking small changes that are otherwise difficult to capture Improved testing conditions will facilitate consistency and replicability Summary: Glaucoma,...
Published: 3/19/2025   |   Inventor(s): Ramesh Ayyala, Sriram Chellappan, John Musser, Ahsan Wahab
Keywords(s): Diagnostics, Ophthalmic Equipment, Ophthalmology
Category(s): zzDiagnostics, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Medical Imaging, Technology Classifications > Medical > Ophthalmology
Viral Vector-Based Gene Therapy for OPA1 Gene Mutation-Induced Dominant Optic Atrophy (UCLA Case No. 2025-004)
UCLA researchers in the Department of Ophthalmology have developed a viral vector-based gene therapy to restore OPA1 protein levels in patients with OPA1-mutated dominant optic atrophy. The optimized vectors will be delivered intravitreally to patients’ eyes, providing a minimally invasive, effective treatment with reduced side effects. BACKGROUND:...
Published: 3/6/2025   |   Inventor(s): Xianjie Yang
Keywords(s): Adeno-associated viruses (AAV), disease model, dominant optic atrophy, Gene Therapy, intravitreal delivery, Lentivirus Viral Vector, mitochondria, mutation, Neuron, OPA1, Ophthalmology, pluripotent stem cell (PSC), retinal ganglion cell
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gene Therapy And Editing, Therapeutics > Ophthalmology
Intravitreal Injection Device (Case No. 2024-136)
Summary: Researchers in the Department of Ophthalmology at UCLA have developed an intravitreal injection device for safer and more precise injections. Background: Intravitreal injections are vital for treating sight-threatening retinal conditions like age-related macular degeneration and diabetic macular edema. These conditions rely heavily on accurate...
Published: 2/28/2025   |   Inventor(s): Taras Gout, Robert Goldberg
Keywords(s): diseases of the eye, Eye Surgery, Macular Degeneration, Ophthalmic antibiotics, Ophthalmology
Category(s): Medical Devices > Surgical Tools, Therapeutics > Ophthalmology, Medical Devices > Hospital Systems
SLURP1 is a Novel Therapeutic Target for Ocular Surface Inflammatory Disorders
Advantages: Identification and validation of SLURP1 as a therapeutic target for treating ocular therapies SLURP1 enhances antioxidant defenses SLURP1 counteracts TGF-β-induced EMT in corneal epithelial cells Potential for Formulating eye care products with SLURP1 to mitigate oxidative stress and maintain corneal epithelial homeostasis (e.g....
Published: 1/24/2025   |   Inventor(s): Shivalingappa Swamynathan, Sudha Swamynathan, Satinder Kaur
Keywords(s): Ophthalmology, Pharmaceuticals
Category(s): Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Ophthalmology
A Method for Promoting Structural and Functional Rescue of Photoreceptors in the Eye to Treat Advanced Retinal Degeneration.
Discovery and use of retina-specific promoters to rescue photoreceptor function specifically at clinically relevant, advanced stages of disease. Problem: Despite the fact that retinal gene therapy studies have shown promising results in animal models, treatment of advanced retinal degeneration with currently available gene therapies have not been successful....
Published: 1/24/2025   |   Inventor(s): Raghavi Sudharsan, William Beltran
Keywords(s): Bioengineering, Gene Therapy, Genetic Disorders, Ophthalmology, Orphan Disease, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Therapeutics
Laser Phacolysis with Portable Laser Diode
Advantages: Low-cost design reduces expenses compared to existing femtosecond laser systems Compact and portable, making it ideal for rural and underserved areas Operates efficiently with low power requirements, suitable for areas with limited electricity Reduces surgical complications common in traditional cataract procedures Innovative...
Published: 1/21/2025   |   Inventor(s): Ashwin Parthasarathy, Mitchell Harrah, Abdul Mohaimen Safi, Sadhu Moka, Ramesh Ayyala
Keywords(s): Ophthalmic Equipment, Ophthalmology, Optical, Laser, Fiberoptic, Spectroscopy
Category(s): Technology Classifications > Medical > Ophthalmology, Technology Classifications > Electronics > Electronics Laser
Goldberg Retractor (Case No. 2024-038)
Intro Sentence: UCLA researchers from the Department of Ophthalmology have developed a surgical retractor for improved ophthalmic plastic surgery. Background: Surgical retractors are commonly used in various medical disciplines and allow for improved visibility and access to delicate anatomical structures during surgical procedures. Traditional...
Published: 2/14/2025   |   Inventor(s): Robert Goldberg, Taras Gout
Keywords(s): diseases of the eye, eye disease, eye motion, eye movement disorders, Eye Surgery, eye tracking, Invasiveness Of Surgical Procedures, Medical Imaging Eyepiece, on-eyelid sensor, Ophthalmology, Preclinical surgical innovation, Surgical Instrument, Surgical Instrument Optical Coherence Tomography, surgical mesh, surgical oncology, Surgical Suture , surgical tool, Surgical Tools
Category(s): Medical Devices, Medical Devices > Surgical Tools, Medical Devices > Hospital Systems
Improving Diagnosis and Treatment of Sarcoidosis
Using a blood or tissue biomarker to improve diagnosis and identification of a new targeted treatment. Problem: Sarcoidosis is an inflammatory disease that can affect any organ, predominantly the lung, skin, and the lymphatic system. Symptoms include difficulty breathing, extreme fatigue, skin inflammation, and joint pain. Sarcoidosis compromises patients’...
Published: 12/5/2024   |   Inventor(s): Thomas Hin-Chai Leung, Satish Sati, Misha Rosenbach
Keywords(s): Dermatology, Immunology, Inflammation, Ophthalmology, Pulmonary
Category(s): Technology Classifications > Diagnostics
CHST6 Mini Gene - CHST6 Expression Construct With Native Promoter (UCLA Case No. 2023-301)
UCLA researchers from the Department of Human Genetics and Department of Ophthalmology have developed a mini gene encoding a protein which is mutated in macular corneal dystrophy, leading to a potential gene therapy for this disorder. BACKGROUND: Macular corneal dystrophy (MCD) is a rare genetic disease caused by mutations in the CHST6 gene, which...
Published: 2/14/2025   |   Inventor(s): Wenlin Zhang, Anthony Aldave
Keywords(s): AAV, Adeno-associated viruses (AAV), Gene Editing Systems, Gene Therapy, genetics, keratinocytes, macular corneal dystrophy, mini gene, mutation, native promoter, Ophthalmology
Category(s): Therapeutics > Ophthalmology, Therapeutics > Gene Therapy And Editing
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