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Search Results - immunoncology
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Tumor Suppression by Retinoic Acid Pathway Inhibition
Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024
|
Inventor(s):
Malay Haldar
,
Ganesha Rai Bantukallu
Keywords(s):
Cell Therapy
,
Drug Target
,
Immunology
,
Immunoncology
,
Oncology
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation. Problem: Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 7/2/2024
|
Inventor(s):
Christopher Hunter
,
Drew Weissman
,
Mohamad Alameh
,
Emily Aunins
,
Anthony Phan
Keywords(s):
Bioengineering
,
Drug Delivery
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Infectious Disease
,
Nanotechnology
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
Topical LSD1 Inhibition for Treating Skin Diseases
Topical LSD1 inhibition can treat skin diseases that include cutaneous squamous cell carcinoma (cSCC), actinic keratoses, and viral warts. Problem: Current treatment options (i.e. cryotherapy, laser therapy, surgery, chemotherapy) for skin diseases such as cSCC, actinic keratoses, and viral warts are often non-targeted and destructive, and can cause...
Published: 2/12/2024
|
Inventor(s):
Brian Capell
,
Napasorn (Nina) Kuprasertkul
Keywords(s):
Dermatology
,
Drug Delivery
,
Drug Target
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Methods for Cryopreservation of Cells for Improved Commercial Manufacture of NK Cell Therapies
A method that maintains the viability and function of NK cells following cryopreservation, enabling the production, storage, and transportation of therapeutic doses of NK cells to treatment centers. Problem: There is a growing interest in using NK cells as immunotherapies for diseases such as cancer. Making commercially viable NK cell therapies requires...
Published: 10/16/2023
|
Inventor(s):
Neil Sheppard
,
Abdulla Berjis
Keywords(s):
Cell Therapy
,
Immunology
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery
Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells. Problem: In recent times, the delivery of mRNA has become a major focus for therapeutics. Intracellular delivery is the major challenge. Intracellular delivery requires ionizable lipids for mRNA delivery. In addition to this, these constituents...
Published: 2/6/2024
|
Inventor(s):
Michael Mitchell
,
Margaret Billingsley
,
Savan Patel
,
Xuexiang Han
,
Hanwen Zhang
Keywords(s):
Bioengineering
,
Cell Therapy
,
Drug Delivery
,
Gene Editing
,
Gene Therapy
,
Genetic Disorders
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Inflammation
,
Nanotechnology
,
Platform Technology
Category(s):
Technology Classifications > Therapeutics
Neuroprotection in TBI/Concussion via Dietary Supplement
A dietary supplement that protects brain cells from the effects of TBI and concussion Problem: Traumatic brain injury (TBI) is a major cause of death and disability. Mild TBIs (such as concussion) are particularly common for athletes and warfighters and can produce disabilities without immediate brain cell death. This may be due to damage to...
Published: 6/24/2024
|
Inventor(s):
Daniel Kacy Cullen
,
Carolyn Keating
,
Kevin Browne
Keywords(s):
Antibody
,
Cell Therapy
,
Immunology
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Platform Technology for Cell Engineering and Cell Programming
A platform technology utilizing synthetic organelles to modulate cell cycle, cell behavior, and stemness/differentiation status which could be used for cell engineering, cell therapy etc. Technology Cells compartmentalize enzymes and their substrates into organelles to insulate or facilitate biochemical reactions. The ability to artificially construct...
Published: 1/10/2024
|
Inventor(s):
Matthew Good
,
Mikael Garabedia
Keywords(s):
Antibody
,
Cell Therapy
,
Immunology
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Research Tools & Reagents
Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis
A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver. Problem: Lipid nanoparticles (LNPs) have been successfully used in FDA-approved therapies to deliver messenger RNA (mRNA) and small interfering RNA (siRNA) . One of the biggest challenge in developing...
Published: 2/7/2024
|
Inventor(s):
Michael Mitchell
,
Xuexiang Han
Keywords(s):
Bioengineering
,
Drug Delivery
,
Gene Editing
,
Gene Therapy
,
Genetic Disorders
,
Immunology
,
Immunoncology
,
Platform Technology
,
Regenerative Medicine
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
Compositions and Methods for Enhancing the Anti-Tumor Activity of CAR T Cells by Co-Expression of CH25H
Co-expression of modified chimeric antigen receptor (CAR) T cells and cholesterol 25-hydroxylase (CH25H) in a single construct for treatment of solid tumor and hematological cancers. Problem: CAR T cell therapy is a treatment in which T cells collected from a patient are engineered to produce CARs that recognize and attack cancer cells. While it...
Published: 7/11/2024
|
Inventor(s):
Serge Fuchs
,
Noreen McBrearty
,
Zhen Lu
Keywords(s):
Bioengineering
,
CAR T-cell Enhancing Technology
,
Cell Therapy
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
Category(s):
Technology Classifications > Therapeutics
CD137 enrichment of tumor-specific tumor-infiltrating lymphocytes (TILs)
A platform to isolate and expand CD137-positive (CD137pos) tumor-infiltrating lymphocytes (TILs) to use in adoptive immunotherapy and translational studies. Problem: Adoptive immunotherapy using either naturally occurring or genetically modified tumor-infiltrating lymphocytes (TILs) is being developed to treat solid tumors clinically. However, methods...
Published: 4/2/2024
|
Inventor(s):
Daniel Powell
Keywords(s):
CAR T-cell Enhancing Technology
,
Cell Therapy
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
Category(s):
Technology Classifications > Research Tools & Reagents
,
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
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