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Search Results - immunoncology
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High-Throughput Approach to Identify New Lipid Nanoparticle Formulations for Vaccine and Drug Delivery
High-throughput in vivo screening method to identify lipid nanoparticle (LNP) formulations for local and systemic delivery for mRNA vaccines and cancer immunotherapies. Problem: Nucleic acid delivery is an attractive and rapidly growing area of research, particularly for the development of vaccines and cancer immunotherapy. Historically, viral vectors...
Published: 12/20/2024
|
Inventor(s):
Michael Mitchell
,
Alex Hamilton
Keywords(s):
Bioengineering
,
COVID-19
,
Drug Delivery
,
Gene Therapy
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Infectious Disease
,
Nanotechnology
Category(s):
Technology Classifications > Testing & Measurement
,
Technology Classifications > Vaccines
,
Technology Classifications > Therapeutics
T-Cell-Activating Lipid Nanoparticles for Rapid Engineering of CAR T Cells
A method to streamline the process of generating chimeric antigen receptor (CAR) T cells for therapeutic applications. Problem: CAR T cell therapy has demonstrated clinical success in treating various forms of cancer. With more CAR T cell therapies projected to gain regulatory approval, manufacturing becomes increasingly important in the face of this...
Published: 12/20/2024
|
Inventor(s):
Ann Metzloff
,
Margaret Billingsley
,
Michael Mitchell
Keywords(s):
Bioengineering
,
Cell Therapy
,
Drug Delivery
,
Immunoncology
,
Immunotherapy
,
Oncology
,
Platform Technology
Category(s):
Technology Classifications > Therapeutics
Method to Alleviate Side Effects of CAR T Cell Immunotherapies
CAR-T cells are PEGylated to block the interactions with monocytes and macrophages to reduce the side effects of CAR-T cell therapies (cytokine release syndrome and neurotoxicity). Problem: CAR-T cell therapies lead to many adverse side effects such as cytokine release syndrome (CRS) and neurotoxicity. It has been shown that 20-70% of patients receiving...
Published: 12/20/2024
|
Inventor(s):
Michael Mitchell
,
Ningqiang Gong
Keywords(s):
Bioengineering
,
Cell Therapy
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Oncology
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Therapeutics
Tumor Suppression by Retinoic Acid Pathway Inhibition
Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024
|
Inventor(s):
Malay Haldar
,
Ganesha Rai Bantukallu
Keywords(s):
Cell Therapy
,
Drug Target
,
Immunology
,
Immunoncology
,
Oncology
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Immune Modulator Encoded Lipid Nanoparticle Formulation Improves T Cell Response to Vaccines
Researchers developed an LNP-mRNA-based vaccine that encodes different cytokine mRNAs, as a method to enhance CD8+ T cell responses and memory formation. Problem: Lipid nanoparticles (LNPs) are an emerging technique to deliver mRNA in vivo more efficiently. While recent progress in mRNA technology has allowed the rapid development of SARS-COV2 vaccines,...
Published: 7/2/2024
|
Inventor(s):
Christopher Hunter
,
Drew Weissman
,
Mohamad Alameh
,
Emily Aunins
,
Anthony Phan
Keywords(s):
Bioengineering
,
Drug Delivery
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Infectious Disease
,
Nanotechnology
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
Topical LSD1 Inhibition for Treating Skin Diseases
Topical LSD1 inhibition can treat skin diseases that include cutaneous squamous cell carcinoma (cSCC), actinic keratoses, and viral warts. Problem: Current treatment options (i.e. cryotherapy, laser therapy, surgery, chemotherapy) for skin diseases such as cSCC, actinic keratoses, and viral warts are often non-targeted and destructive, and can cause...
Published: 2/12/2024
|
Inventor(s):
Brian Capell
,
Napasorn (Nina) Kuprasertkul
Keywords(s):
Dermatology
,
Drug Delivery
,
Drug Target
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Methods for Cryopreservation of Cells for Improved Commercial Manufacture of NK Cell Therapies
A method that maintains the viability and function of NK cells following cryopreservation, enabling the production, storage, and transportation of therapeutic doses of NK cells to treatment centers. Problem: There is a growing interest in using NK cells as immunotherapies for diseases such as cancer. Making commercially viable NK cell therapies requires...
Published: 10/16/2023
|
Inventor(s):
Neil Sheppard
,
Abdulla Berjis
Keywords(s):
Cell Therapy
,
Immunology
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery
Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells. Problem: In recent times, the delivery of mRNA has become a major focus for therapeutics. Intracellular delivery is the major challenge. Intracellular delivery requires ionizable lipids for mRNA delivery. In addition to this, these constituents...
Published: 2/6/2024
|
Inventor(s):
Michael Mitchell
,
Margaret Billingsley
,
Savan Patel
,
Xuexiang Han
,
Hanwen Zhang
Keywords(s):
Bioengineering
,
Cell Therapy
,
Drug Delivery
,
Gene Editing
,
Gene Therapy
,
Genetic Disorders
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Inflammation
,
Nanotechnology
,
Platform Technology
Category(s):
Technology Classifications > Therapeutics
Neuroprotection in TBI/Concussion via Dietary Supplement
A dietary supplement that protects brain cells from the effects of TBI and concussion Problem: Traumatic brain injury (TBI) is a major cause of death and disability. Mild TBIs (such as concussion) are particularly common for athletes and warfighters and can produce disabilities without immediate brain cell death. This may be due to damage to...
Published: 6/24/2024
|
Inventor(s):
Daniel Kacy Cullen
,
Carolyn Keating
,
Kevin Browne
Keywords(s):
Antibody
,
Cell Therapy
,
Immunology
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Platform Technology for Cell Engineering and Cell Programming
A platform technology utilizing synthetic organelles to modulate cell cycle, cell behavior, and stemness/differentiation status which could be used for cell engineering, cell therapy etc. Technology Cells compartmentalize enzymes and their substrates into organelles to insulate or facilitate biochemical reactions. The ability to artificially construct...
Published: 1/10/2024
|
Inventor(s):
Matthew Good
,
Mikael Garabedia
Keywords(s):
Antibody
,
Cell Therapy
,
Immunology
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Research Tools & Reagents
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