Search Results - lulu+xue

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Biocompatible And Low-Toxicity Lipid Nanoparticles (LNPs) For Selectively Delivering mRNA To The Bone Microenvironment
Ionizable LNPs with a rigid backbone of piperazine (PIP) linked to bisphosphonates (BPs) for the targeted delivery of mRNA to the bone. Problem: Available treatments for bone tissue related diseases provide only symptomatic relief and are associated with clinical challenges and potential side effects. Challenges persist in the delivery of therapeutic...
Published: 3/7/2025   |   Inventor(s): Michael Mitchell, Kyle Vining, Lulu Xue, Il-Chul Yoon
Keywords(s): Aging, Bioengineering, Drug Delivery, Gene Therapy, Orthopedics, Platform Technology, Women's Health
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Macrophage-Targeting Lipid Nanoparticles (MacLNPs) Deliver siRNA Intranasally to Treat Viral Pneumonia
siRNA-LNP knock-down of TAK1 delivered intranasally and to macrophages specifically prevents inflammation-induced pathology in a mouse model Problem: Macrophages are an important component of the innate immune system, but can mediate excessive inflammation and cause severe pathology if left unchecked. This poses a challenge for the treatment of acute...
Published: 12/19/2024   |   Inventor(s): Michael Mitchell, Lulu Xue, Andrew Vaughan, Gan Zhao
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Immunology, Infectious Disease, Inflammation, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Lipid Nanoparticles That Specifically Target The Lungs
Lung-targeting lipid nanoparticles allowing organ specific mRNA delivery for gene therapy applications. Problem: Gene therapy via mRNA delivery allows the rapid generation of therapeutics and vaccines for a wide range of applications. However, mRNA is especially vulnerable to degradation in the body, necessitating packaging within lipid nanoparticles....
Published: 10/17/2024   |   Inventor(s): Michael Mitchell, Lulu Xue
Keywords(s): Bioengineering, COVID-19, Gene Therapy, Infectious Disease, Pulmonary
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo
A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. Problem: The increasing prevalence of skeletal diseases such as osteoporosis, osteoarthritis and bone cancer have motivated efforts to target the bone microenvironment therapeutically. However, therapeutic agents must overcome...
Published: 3/6/2025   |   Inventor(s): Michael Mitchell, Lulu Xue
Keywords(s): Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents
Network-Coded Multiple Access
[Licensing negotiation in progress] [Invitation for Expression of Interest - Deadline: 16 June 2016] Systems and methods include a first wireless local area network (WLAN) system that jointly exploit physical-layer network coding (PNC) and multi-user decoding (MUD) to boost system throughput. This multiple access mode is referred to as Network-Coded...
Published: 1/29/2024   |   Inventor(s): Soung Chang Liew, Lu LU, Lizhao You
Keywords(s): Network Coding, Wireless Local Area Network
Category(s): Information and Communications Technology
Thermoelectric Materials Based on Tetrahedrite Structure for the Thermoelectric Devices
IntroductionGrowing concern with energy independence and sustainability has initiated research into methods that can help to increase energy efficiency. One method, thermoelectric devices, converts waste heat from current processes into energy. These devices take advantage of a temperature gradient across the device, creating a voltage from the temperature...
Published: 5/16/2023   |   Inventor(s): Donald Morelli, Xu Lu, Vidvuds Ozolins
Keywords(s):  
Category(s): Advanced Materials, Energy
Natural Mineral Tetrahedrite as a Direct Source of Thermoelectric Materials
IntroductionThermoelectric (TE) materials make possible the direct conversion of waste heat into electricity, potentially improving energy efficiency or providing an alternative energy source. TE materials experience the thermoelectric effect, whereby voltage is generated when there is a temperature gradient within the material. Since 1995, advances...
Published: 2/17/2023   |   Inventor(s): Donald Morelli, Xu Lu
Keywords(s):  
Category(s): Energy, Electrical, Materials