Search Results - lulu+xue

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Lipid Nanoparticles That Specifically Target The Lungs
Lung-targeting lipid nanoparticles allowing organ specific mRNA delivery for gene therapy applications. Problem: Gene therapy via mRNA delivery allows the rapid generation of therapeutics and vaccines for a wide range of applications. However, mRNA is especially vulnerable to degradation in the body, necessitating packaging within lipid nanoparticles....
Published: 10/17/2024   |   Inventor(s): Michael Mitchell, Lulu Xue
Keywords(s): Bioengineering, COVID-19, Gene Therapy, Infectious Disease, Pulmonary
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics, Technology Classifications > Vaccines
y-AApeptide-based long-acting pan-coronavirus fusion inhibitor with dual targets in spike protein and oral bioavailability
­Advantages: S-20-1 demonstrates potent inhibitory action, this broad-spectrum activity suggests that S-20-1 could be effective against a wide range of coronaviruses, making it a valuable candidate for pandemic preparedness and management. The research provides insights into the mechanism of action of S-20-1, demonstrating its ability to bind...
Published: 9/25/2023   |   Inventor(s): Jianfeng Cai, Shibo JIANG, Lu LU, Songyi XUE, Xinling WANG, Lei WANG, Wei XU, Shuai XIA
Keywords(s): Drug Discovery, Immunology
Category(s): Technology Classifications > Medical > Biotechnology
RGD Peptide-Based Lipids For Targeted mRNA Delivery and Gene Editing Applications
A combinatorial library of RGD peptide (arginine-glycine-aspartic acid)-based lipids designed to formulate lipid nanoparticles for targeted mRNA delivery to the liver and the spleen. Problem: Lipid Nanoparticles (LNPs) are becoming an established choice of vehicle to deliver mRNA-based therapeutics, including vaccines, protein replacement therapies,...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Lulu Xue, Jingya Qin
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo
A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. Problem: The increasing prevalence of skeletal diseases such as osteoporosis, osteoarthritis and bone cancer have motivated efforts to target the bone microenvironment therapeutically. However, therapeutic agents must overcome...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Lulu Xue
Keywords(s): Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents
Network-Coded Multiple Access
[Licensing negotiation in progress] [Invitation for Expression of Interest - Deadline: 16 June 2016] Systems and methods include a first wireless local area network (WLAN) system that jointly exploit physical-layer network coding (PNC) and multi-user decoding (MUD) to boost system throughput. This multiple access mode is referred to as Network-Coded...
Published: 1/29/2024   |   Inventor(s): Soung Chang Liew, Lu LU, Lizhao You
Keywords(s): Network Coding, Wireless Local Area Network
Category(s): Information and Communications Technology
Thermoelectric Materials Based on Tetrahedrite Structure for the Thermoelectric Devices
IntroductionGrowing concern with energy independence and sustainability has initiated research into methods that can help to increase energy efficiency. One method, thermoelectric devices, converts waste heat from current processes into energy. These devices take advantage of a temperature gradient across the device, creating a voltage from the temperature...
Published: 5/16/2023   |   Inventor(s): Donald Morelli, Xu Lu, Vidvuds Ozolins
Keywords(s):  
Category(s): Advanced Materials, Energy
Natural Mineral Tetrahedrite as a Direct Source of Thermoelectric Materials
IntroductionThermoelectric (TE) materials make possible the direct conversion of waste heat into electricity, potentially improving energy efficiency or providing an alternative energy source. TE materials experience the thermoelectric effect, whereby voltage is generated when there is a temperature gradient within the material. Since 1995, advances...
Published: 2/17/2023   |   Inventor(s): Donald Morelli, Xu Lu
Keywords(s):  
Category(s): Energy, Electrical, Materials