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Search Results - xuexiang+han
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Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery
Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells. Problem: In recent times, the delivery of mRNA has become a major focus for therapeutics. Intracellular delivery is the major challenge. Intracellular delivery requires ionizable lipids for mRNA delivery. In addition to this, these constituents...
Published: 2/6/2024
|
Inventor(s):
Michael Mitchell
,
Margaret Billingsley
,
Savan Patel
,
Xuexiang Han
,
Hanwen Zhang
Keywords(s):
Bioengineering
,
Cell Therapy
,
Drug Delivery
,
Gene Editing
,
Gene Therapy
,
Genetic Disorders
,
Immunology
,
Immunoncology
,
Immunotherapy
,
Inflammation
,
Nanotechnology
,
Platform Technology
Category(s):
Technology Classifications > Therapeutics
Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis
A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver. Problem: Lipid nanoparticles (LNPs) have been successfully used in FDA-approved therapies to deliver messenger RNA (mRNA) and small interfering RNA (siRNA) . One of the biggest challenge in developing...
Published: 2/7/2024
|
Inventor(s):
Michael Mitchell
,
Xuexiang Han
Keywords(s):
Bioengineering
,
Drug Delivery
,
Gene Editing
,
Gene Therapy
,
Genetic Disorders
,
Immunology
,
Immunoncology
,
Platform Technology
,
Regenerative Medicine
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Vaccines
Double-Negative-Index Ceramic Aerogels For Thermal Superinsulation
Summary: UCLA researchers in the Departments of Chemistry and Biochemistry and Materials Science and Engineering have developed a novel ceramic aerogel material that has robust mechanical and thermal stability under extreme conditions. Background: Thermal insulation used in industries like aerospace and thermal power fields requires resistance to...
Published: 2/15/2024
|
Inventor(s):
Xiangfeng Duan
,
Yu Huang
,
Xiang Xu
Keywords(s):
Chemical Manufacturing & Industrial/Bulk Chemicals
,
Structures
Category(s):
Chemical > Industrial & Bulk Chemicals