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Search Results - drug+target
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Tumor Suppression by Retinoic Acid Pathway Inhibition
Targeting retinoic acid (RA) synthesizing enzymes or RA receptors with small molecules boosts the immune system towards a tumor rejection response Problem: Hepatocellular carcinoma (HCC) is the most common liver cancer globally. In the US alone, 33 000 patients are diagnosed yearly, 27 000 of which will die. Once metastasized, HCC shows...
Published: 6/21/2024
|
Inventor(s):
Malay Haldar
,
Ganesha Rai Bantukallu
Keywords(s):
Cell Therapy
,
Drug Target
,
Immunology
,
Immunoncology
,
Oncology
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
Silencing of PRLΔE1 expression: a gene-agnostic treatment for retinal degenerations
Viral vector-mediated gene silencing of a novel short retinal isoform of Prolactin promotes photoreceptor survival. Problem: Age-related macular degeneration (AMD) and inherited retinal degeneration (IRDs) have extreme mutational heterogeneity, and many IRDs are orphan diseases. Developing individual gene therapies for each causative gene is impractical...
Published: 7/2/2024
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Inventor(s):
William Beltran
,
Raghavi Sudharsan
Keywords(s):
Drug Target
,
Gene Therapy
,
Genetic Disorders
,
Neurodegenerative Diseases
,
Ophthalmology
,
Orphan Disease
Category(s):
Technology Classifications > Therapeutics
Topical LSD1 Inhibition for Treating Skin Diseases
Topical LSD1 inhibition can treat skin diseases that include cutaneous squamous cell carcinoma (cSCC), actinic keratoses, and viral warts. Problem: Current treatment options (i.e. cryotherapy, laser therapy, surgery, chemotherapy) for skin diseases such as cSCC, actinic keratoses, and viral warts are often non-targeted and destructive, and can cause...
Published: 2/12/2024
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Inventor(s):
Brian Capell
,
Napasorn (Nina) Kuprasertkul
Keywords(s):
Dermatology
,
Drug Delivery
,
Drug Target
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Accurate Blood Biomarkers for Early Diagnosis of Synovial Joint Disease in the Mucopolysaccharidoses
Ten candidate serum and synovial protein levels provide early indication of joint impairment in lysosomal storage disorders. Problem: The Mucopolysaccharidoses (MPS) group of lysosomal storage diseases occur once in every 25,000 births, all MPS subtypes share deficits in enzymatic degradation. Children with MPS suffer from a suite of variable and...
Published: 6/20/2024
|
Inventor(s):
Lachlan Smith
,
Chenghao Zhang
Keywords(s):
Bioengineering
,
Cell Therapy
,
Drug Target
,
Genetic Disorders
,
Inflammation
,
Orthopedics
,
Regenerative Medicine
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Testing & Measurement
Library of Novel Anesthetic (Propofol) Antagonists
A library of chemical compounds that reverse the anesthetic effects of propofol. Problem: Propofol is one of the most commonly used anesthetics in medical care. It is used to induce and maintain sedation in surgeries, ICU care, emergency care, and other procedures. However, there currently is no pharmacological method for reversing propofol-induced...
Published: 2/2/2024
|
Inventor(s):
Elizabeth White
,
Roderic Eckenhoff
,
William Dailey
,
Kellie Woll
,
Andrew McKinstry-Wu
,
Victoria Bedell
Keywords(s):
Drug Target
,
Surgery
Category(s):
Technology Classifications > Chemical Processes and Synthesis
Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo
A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. Problem: The increasing prevalence of skeletal diseases such as osteoporosis, osteoarthritis and bone cancer have motivated efforts to target the bone microenvironment therapeutically. However, therapeutic agents must overcome...
Published: 2/7/2024
|
Inventor(s):
Michael Mitchell
,
Lulu Xue
Keywords(s):
Drug Delivery
,
Drug Target
,
Nanotechnology
,
Orthopedics
,
Platform Technology
,
Regenerative Medicine
Category(s):
Technology Classifications > Vaccines
,
Technology Classifications > Therapeutics
,
Technology Classifications > Research Tools & Reagents
A method to induce ferroptosis and to downregulate androgen receptor/androgen receptor splice variant in prostate cancer cells
Prostate cancer (PCa) effects approximately three million men in the United States every year. About 10-20% of the cases of prostate cancer are castrate-resistant prostate cancer (CRPC). This form of PCa is highly resistant to what Is known as androgen depletion therapy and is often fatal. All types of PCa are sensitive to androgen receptor signaling...
Published: 10/26/2023
|
Inventor(s):
Zhihui Qin
,
Liping Xu
Keywords(s):
Anti-cancer
,
Cancer
,
Cancer Therapies
,
Drug Delivery
,
Drug Target
,
Prostate Cancer
Category(s):
Medical
,
Diseases
,
Drug Discovery
,
Pharmaceuticals
,
Oncology
Up-regulators of utrophin expression for the treatment of muscular dystrophy
Small molecules targeting utrophin mRNA untranslated regions overcome post-transcriptional repression Problem: Duchenne Muscular Dystrophy (DMD) is an X-linked neuromuscular disorder that affects approximately 1 in 3500 males worldwide. DMD is caused by mutations in the DMD gene that lead to severe reduction or loss of dystrophin protein. Without...
Published: 6/20/2024
|
Inventor(s):
Tejvir Khurana
,
Donna Huryn
Keywords(s):
Drug Target
,
Genetic Disorders
Category(s):
Technology Classifications > Therapeutics
Therapeutic to Mitigate Epilepsy and Autism Development in Newborn Seizure Patients
Neonatal brains are at high risk for seizures due to heightened electrical activity corresponding to neural development. Though anticonvulsant drugs exist to treat the seizures immediately, certain synaptic receptors (CP-AMPARs) become highly expressed, increasing the likelihood of developing epilepsy and autism-spectrum disorders. The inventors propose...
Published: 1/12/2024
|
Inventor(s):
Frances Jensen
Keywords(s):
Drug Target
,
Neurology
Category(s):
Technology Classifications > Therapeutics
A Gene Knockout Mouse Model to Study Lung Disease and a Lung Disease
Drug Target
Our researchers have created a gene knockout mouse model that lacks the cytochrome c oxidase subunit IV-2 in order to study the gene’s effects on controlling asthma. Background & Unmeet Need: Asthma is an inflammatory disease of the airways that affects 155 million people of all ages worldwide. Cytochome c oxidase (CcO) is a multi-subunit...
Published: 3/3/2022
|
Inventor(s):
Maik Huettemann
,
Lawrence Grossman
,
David Bassett
Keywords(s):
Asthma
,
Disease
,
Drug Target
,
Gene
,
Knock-out
,
Lung
,
Mouse Model
Category(s):
Animal models
,
Biological materials
,
Life Science
,
Research tools
,
Protein/peptides
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