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Search Results - aging
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An Adaptive, Language-Agnostic, and Generalizable Method to Determine the Hearing Level and Speech Perception Abilities of a Patient
This hearing test is tuned to a patient’s hearing level and changes based on performance to accurately diagnose hearing ability Problem: Currently, no single hearing evaluation can determine multiple facets of an individual’s hearing ability. For example, some tests may determine hearing awareness at specific frequencies, but gather no data...
Published: 8/12/2024
|
Inventor(s):
Jason Brant
,
Tiffany Hwa
Keywords(s):
Aging
,
Neurodegenerative Diseases
,
Software
,
Surgery
Category(s):
Technology Classifications > Diagnostics
,
Technology Classifications > Testing & Measurement
Biomaterial-Based Vaccine Booster to Enhance Long-Term Immunity (UCLA Case No. 2021-170)
UCLA researchers have developed injectable, cell-free, and biomaterial-based microparticles that can engage with tissue resident immune cells and enhance long-term immunity. It is the first biomaterial-based, targeted approach to induce T memory stem cells (TMSCs) in vivo. The approach was demonstrated for SARS-CoV-2 but can be used for any vaccine....
Published: 2/26/2024
|
Inventor(s):
Mohammad Hasani-Sadrabadi
,
Song Li
,
Manish Butte
Keywords(s):
aAPCs
,
Aging
,
artificial presenting cells
,
cytokines
,
elderly
,
immunosenescence
,
microparticles
,
platform technology
,
SARS-CoV-2
,
T memory stem cells
,
TMSCs
,
Vaccines
Category(s):
Therapeutics > Infectious Diseases
,
Therapeutics > Oncology
Small Molecule Activators of Valosin-Containing Protein (VCP) as Therapeutics for Neurodegenerative Diseases with Ubiquitinated Protein Aggregates
Small molecule therapeutics that aid in clearing abnormal protein deposits observed in neurodegenerative diseases. Problem: Dementia, characterized by the impairment of at least two brain functions, such as memory loss and judgment, currently has no cure. Two common neurodegenerative diseases that cause dementia are Frontotemporal Dementia (FTD) and...
Published: 2/9/2024
|
Inventor(s):
Edward Lee
,
Benjamin Creekmore
,
Jessica Phan
Keywords(s):
Aging
,
Genetic Disorders
,
Neurodegenerative Diseases
,
Neurology
,
Orphan Disease
,
Small Molecule
Category(s):
Technology Classifications > Therapeutics
In vitro Generation of an Autologous Thymic Organoid from Human Pluripotent Stem Cells
Abstract: The thymus is an integral part of the adaptive immune system as it generates T cells. Its function diminishes rapidly as the body ages, leading to a compromise of the immune system in the elderly. Reconstitution of adaptive immunity through mass production of different T cell types is therefore a therapeutic need in immunocompromised populations....
Published: 4/8/2024
|
Inventor(s):
Raul Sakoda
,
Nicholas Restifo
Keywords(s):
Aging
,
IMMUNOCOMPROMISED
,
Immunotherapy
,
Natural Killer T Cells
,
NKT
,
Organogenesis
,
Organoid
,
Pluripotent Stem Cells
,
T Cells
,
THYMUS
,
Vizcardo
Category(s):
Application > Therapeutics
,
TherapeuticArea > Oncology
,
TherapeuticArea > Immunology
,
Collaboration Sought > Licensing
Method for Creating Super Resolution Medical Images
The deep learning algorithm retrospectively improves the resolution of routine medical images (e.g., CT, MRI, etc.) without the need for increased radiation or scan time. Technology: Clinical medical images often have low resolution due to radiation-dose or scan-time restrictions. Inventors developed a probabilistic deep learning model to improve...
Published: 9/24/2024
|
Inventor(s):
Chamith Rajapakse
Keywords(s):
Aging
,
Artificial Intelligence (AI) & Machine Learning
,
Cell Therapy
,
Orthopedics
,
Radiology
,
Software
Category(s):
Technology Classifications > Im
aging
Novel Roles of a DNA Repair Protein, DNA-PKcs, in Obesity, Neurological Function, and
Aging
The catalytic subunit of the DNA-dependent protein kinase complex (DNA-PKcs) has been shown to be important in DNA repair and VDJ recombination in lymphocytes. The inventors have discovered that DNA-PKcs also plays novel, important roles in energy regulation and neurological function. The inventors observed that mature DNA-PKcs-deficient mice (also...
Published: 7/25/2024
|
Inventor(s):
Jay Chung
Keywords(s):
Aging
,
ANXIETY
,
Cardiovascular
,
depression
,
DIABETES
,
DNA-Dependent
,
DNA-PKcs
,
Endurance
,
Energy
,
HEART
,
IB1XXX
,
IB3XXX
,
IB6XXX
,
IBXXXX
,
Inflammation
,
insulin
,
INSULIN-DEPENDENT
,
IXXXXX
,
LEARNING
,
MEMORY
,
METABOLIC
,
Metabolism
,
Mitochondria
,
Neurological
,
OBESITY
,
REGULATION
,
TYPE-2
,
Weight
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Diagnostics
,
Application > Research Materials
,
Application > Vaccines
,
Application > Therapeutics
,
TherapeuticArea > Cardiology
,
TherapeuticArea > Reproductive Health
,
TherapeuticArea > Immunology
Novel Pyrimidine Derivatives to Treat Alzheimer’s Disease
Brain penetrating compounds as promising therapeutics for treatment of neurodegenerative disorders. Problem: An estimated 6.2 million Americans live with Alzheimer’s Disease (AD), and this number is projected to reach over 13 million by 2050 with societal costs expected to rise to $1.1 trillion. A key feature of AD-affected brain tissue is the...
Published: 6/28/2024
|
Inventor(s):
Kurt Brunden
,
Carlo Ballatore
,
Amos Smith
,
Virginia Lee
,
John Trojanowski
Keywords(s):
Aging
,
Neurodegenerative Diseases
,
Neurology
,
Small Molecule
Category(s):
Technology Classifications > Chemical Processes and Synthesis
,
Technology Classifications > Therapeutics
2019-480: DNA Methylation Based Estimator of Telomere Length
UCLA researchers in the Department of Human Genetics and Biostatistics have developed a tool that utilizes DNA methylation biomarkers to estimate telomere length. The technology has great potential to monitor and evaluate interventions applied to age-related conditions.BACKGROUND: Telomeres are repetitive nucleotide sequences at the end of chromosomes...
Published: 7/19/2023
|
Inventor(s):
Stefan Horvath
Keywords(s):
Aging
,
Diagnostic Markers & Platforms
,
Diagnostic Platform Technologies (E.G. Microfluidics)
,
Life Science Research Tools
,
Research Methods
Category(s):
Life Science Research Tools > Research Methods
,
Diagnostic Markers >
Aging
,
Platforms > Diagnostic Platform Technologies
2018-734 MITOCHONDRIAL DNA DELETION MUTATION ASSAY
INTRODUCTION:UCLA researchers in the Department of Geriatric Medicine have developed a novel method for the concurrent quantification of mitochondrial DNA content and mutation frequency in both single cells and tissue homogenates.BACKGROUND:The human mitochondrial DNA (mtDNA) genome consists of about 37 genes, all of which are essential for mitochondrial...
Published: 7/19/2023
|
Inventor(s):
Jonathan Wanagat
,
Allen Herbst
Keywords(s):
Aging
,
Diagnostic Markers & Platforms
,
Life Science Research Tools
,
Research Methods
Category(s):
Life Science Research Tools > Research Methods
,
Diagnostic Markers >
Aging
Gene for Successful
Aging
Without Cognitive Decline
Title: Biomarker for Successful
Aging
without Cognitive Decline Current State of the Art: It is estimated that up to one third of adults will experience a gradual decline in cognitive function known as mild cognitive impairment as they age. Individuals with cognitive decline are able to function reasonably well in everyday activities, such as managing...
Published: 6/21/2021
|
Inventor(s):
Shirley Poduslo
Keywords(s):
Aging
,
Alzheimer's Disease
,
Therapeutics
Category(s):
Diagnostics
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