Search Results - raghavi+sudharsan

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A Method for Promoting Structural and Functional Rescue of Photoreceptors in the Eye to Treat Advanced Retinal Degeneration.
Discovery and use of retina-specific promoters to rescue photoreceptor function specifically at clinically relevant, advanced stages of disease. Problem: Despite the fact that retinal gene therapy studies have shown promising results in animal models, treatment of advanced retinal degeneration with currently available gene therapies have not been successful....
Published: 1/24/2025   |   Inventor(s): Raghavi Sudharsan, William Beltran
Keywords(s): Bioengineering, Gene Therapy, Genetic Disorders, Ophthalmology, Orphan Disease, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Therapeutics
Silencing of PRLΔE1 expression: a gene-agnostic treatment for retinal degenerations
Viral vector-mediated gene silencing of a novel short retinal isoform of Prolactin promotes photoreceptor survival. Problem: Age-related macular degeneration (AMD) and inherited retinal degeneration (IRDs) have extreme mutational heterogeneity, and many IRDs are orphan diseases. Developing individual gene therapies for each causative gene is impractical...
Published: 7/2/2024   |   Inventor(s): William Beltran, Raghavi Sudharsan
Keywords(s): Drug Target, Gene Therapy, Genetic Disorders, Neurodegenerative Diseases, Ophthalmology, Orphan Disease
Category(s): Technology Classifications > Therapeutics
Cost-Effective Single-Step Process for the Catalytic Conversion of Methane to Methanol/Formaldehyde
Unmet Need: Currently there is no technology available in the market capable of producing Dimethyl Ether (DME) from methane in a single reactor. DME is an attractive substitute for diesel due to its high cetane number, which is a measure of its ignitibility in compression ignition engines. In addition, DME’s quiet combustion and inability to form...
Published: 10/8/2024   |   Inventor(s): Su Ha, M Norton, Oscar Marin Flores
Keywords(s):  
Category(s): Technologies > Health & Well-being > Chemistry, Technologies > Energy & Environment > Energy