Search Results - high-throughput

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METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS
­METHODS FOR ULTRA-HIGH-THROUGHPUT PROFILING OF NUCLEIC ACID BINDING OR MODIFYING PROTEINS Researchers at Stanford have developed a novel method for the mapping of nucleic acid binding or modifying proteins in a massively multiplexed manner. Next generation sequencing (NGS) has allowed for sequence-agnostic sequencing and has revolutionized every...
Published: 4/22/2024   |   Inventor(s): Polly Fordyce
Keywords(s): High-Throughput, Microfluidics, Protein-DNA Interactions
Category(s): Technology Classifications > Engineering
­HYDROGEL PURIFICATION OF CELL MATERIALS FOR PCR-ACTIVATED CELL SORTING
­HYDROGEL PURIFICATION OF CELL MATERIALS FOR PCR-ACTIVATED CELL SORTING Researchers at the NIH and UCSF have developed methods that detect RNA or DNA markers with single molecule sensitivity in cells of interest that allow rapid isolation of these cells or extracts/derivatives of these cells for in-depth transcriptomic, genomic or epigenomic analyses....
Published: 10/26/2023   |   Inventor(s): Adam Abate, Iain Clark, Eli Boritz
Keywords(s): High-Throughput, Hydrogel, Microfluidic, Single Cell Genomics, Single Cell Transcriptomics
Category(s): Technology Classifications > Biology
­ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING
­ARRAY PLATFORM FOR HIGH-THROUGHPUT ORGANOID PROFILING Researchers at Stanford have developed a new methodology for image processing that allows for high-throughput characterization of organoid phenotypes. Organoids represent a major step forward in in vitro research studies into a myriad of disease states. 3D organoid models possess key advantages...
Published: 9/14/2023   |   Inventor(s): Polly Fordyce, Christina Curtis, Alexandera Sockell, Wing Wong
Keywords(s): CRISPR, High-Throughput, Imaging, Organoid
Category(s): Technology Classifications > Biology
Automatic System and Method for Tissue Sectioning, Staining, and Scanning
Abstract: Computer and imaging technologies led to the development of digital pathology and the capture and storage of pathological specimens as digitally formatted images. The use of artificial intelligence (AI) in digital pathology, such as in three-dimensional (3D) reconstruction, requires analyses of high volumes of data. This results in increased...
Published: 4/8/2024   |   Inventor(s): Zhengping (Ping) Zhuang, Young-Wan Moon
Keywords(s): AI, Artificial Intelligence, AUTOMATION, Digital Pathology, High-throughput, Histology, IMAGING, Zhuang
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, TherapeuticArea > Neurology, TherapeuticArea > Infectious Disease, Application > Medical Devices, Application > Non-Medical Devices
Exo-Clean Technology for Purifying Extracellular Vesicle Preparations from Contaminants
Abstract: Extracellular Vesicles (EVs), including exosomes and microvesicles, are nanometer-sized membranous vesicles that can carry different types of cargos, such as proteins, nucleic acids and metabolites. EVs are produced and released by most cell types. They act as biological mediators for intercellular communication via delivery of their cargos....
Published: 8/14/2024   |   Inventor(s): Jennifer Jones, Jay Berzofsky, Joshua Welsh, Katherine McKinnon
Keywords(s): Affinity, Biomarkers, CHROMATOGRAPHIC, EVs, Exo-Clean, Exosomes, Extracellular Vesicles, High-throughput, Jones, Microvesicles, purification, Resin
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Endocrinology, TherapeuticArea > Immunology
Biomarker Analysis Software for High-Throughput Diagnostic Multiplex Data
Abstract: Extracellular vesicles (EVs) are lipid bilayer-enclosed particles that are released from cells. EVs may contain proteins derived from their cells of origin with the potential as diagnostic biomarkers indicating the state of the cells when released. However, due to their small size (50-1000nm), the methods currently used to phenotype EVs have...
Published: 8/14/2024   |   Inventor(s): Joshua Welsh, Jennifer Jones, Jay Berzofsky
Keywords(s): Berzofsky, Biomarker, EV, Extracellular Vesicles, High-throughput, Jones, Lipid Bilayer-Enclosed Particles, software
Category(s): Application > Software / Apps, TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Automated Digital Pathology Device for High-Throughput Demand
Abstract: Computer and imaging technologies led to the development of digital pathology and the capture and storage of pathological specimens as digitally formatted images. The use of artificial intelligence (AI) in digital pathology, such as in three-dimensional (3D) reconstruction, requires analyses of high volumes of data. This resulted in increased...
Published: 4/8/2024   |   Inventor(s): Zhengping (Ping) Zhuang, Young-Wan Moon, Anthony Cappadona
Keywords(s): AI, Artificial Intelligence, AUTOMATION, Digital Pathology, High-throughput, Histology, IMAGING, Zhuang
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Non-Medical Devices, TherapeuticArea > Neurology, Application > Medical Devices, TherapeuticArea > Oncology
A New High-Throughput Cell Biology Method to Screen for Genes Critical for Cell Differentiation
A high-throughput method for identifying genes involved in the process of stem cell differentiation into specialized cells. Background: One of the many draws of stem cells is their potential for regenerating tissues, nerves, and other organs, but the differentiation potential of stem cells is highly regulated by genes. Therefore, the ability to...
Published: 7/11/2023   |   Inventor(s): Chunyu Liu
Keywords(s): cell culture, development, differentiation, high-throughput, neuroscience, regenerative medicine, screen
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy
SINGLE-CELL EPIGENOMIC PROFILING USING DROPLET FLUIDICS AND CHEMICALLY MODIFIED HYDROGELS
SINGLE-CELL EPIGENOMIC PROFILING USING DROPLET FLUIDICS AND CHEMICALLY MODIFIED HYDROGELS Researchers at UCSF have developed materials and methods for high throughput single cell epigenomic sequencing using a capture/profiling approach with hydrogel scaffolds, thus facilitating a scale and form of epigenomic profiling beyond what has been previously...
Published: 7/6/2023   |   Inventor(s): Adam Abate, Xiangpeng Li
Keywords(s): DNA Capture, Droplet, Epigenomic, High-Throughput, Hydrogel, Microfluidic, Single-Cell
Category(s): Technology Classifications > Biology
METHODS FOR FRAGMENTING COMPLIMENTARY DNA
METHODS FOR FRAGMENTING COMPLIMENTARY DNA Researchers at UCSF have discovered a new method for fragmenting complimentary DNA for sequencing applications. Sequencing of nucleic acids is one of the most important and transformational methods in biomedical sciences. In recent years, high throughput sequencing has become commonplace in both academic and...
Published: 7/6/2023   |   Inventor(s): Derek Bogdanoff, Chang Kim, Tomasz Nowakowski
Keywords(s): Barcode, cDNA, High-Throughput, Long-read Sequencing, Short Read Sequencing, Transposon, UMI
Category(s): Technology Classifications > Biology
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