Search Results - michael+mitchell

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RGD Peptide-Based Lipids For Targeted mRNA Delivery and Gene Editing Applications
A combinatorial library of RGD peptide (arginine-glycine-aspartic acid)-based lipids designed to formulate lipid nanoparticles for targeted mRNA delivery to the liver and the spleen. Problem: Lipid Nanoparticles (LNPs) are becoming an established choice of vehicle to deliver mRNA-based therapeutics, including vaccines, protein replacement therapies,...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Lulu Xue, Jingya Qin
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Oncology, Platform Technology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Ionizable Lipid Nanoparticles For In Vivo mRNA Delivery To The Placenta During Pregnancy
Lipid nanoparticles for selective mRNA delivery to the placenta to treat pre-eclampsia, FGR, and other pregnancy-related disorders. Problem: 3-8% of pregnant women experience pre-eclampsia, or insufficient blood flow to the placenta. In severe cases, this can cause fetal growth restriction (FGR), in which the developing fetus cannot receive adequate...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Kelsey Swingle
Keywords(s): Bioengineering, Drug Delivery, Gene Therapy, Platform Technology, Women's Health
Category(s): Technology Classifications > Therapeutics
Cholesterol Analogues Incorporated Into LNPs For Enhanced mRNA Delivery
Hydroxycholesterols are used to formulate lipid nanoparticles (LNPs) for enhanced mRNA delivery into T cells. Problem: In recent times, the delivery of mRNA has become a major focus for therapeutics. Intracellular delivery is the major challenge. Intracellular delivery requires ionizable lipids for mRNA delivery. In addition to this, these constituents...
Published: 2/6/2024   |   Inventor(s): Michael Mitchell, Margaret Billingsley, Savan Patel, Xuexiang Han, Hanwen Zhang
Keywords(s): Bioengineering, Cell Therapy, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Immunotherapy, Inflammation, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Therapeutics
Amniotic Fluid Stabilized Lipid Nanoparticles (LNPs) for In Utero Intra-Amniotic mRNA Delivery
Nanoparticles for potent encapsulation and delivery of therapeutic molecules for prenatal fetal therapy in the amniotic sac Problem: Many prenatal genetic diseases suffer from ineffective postnatal treatments. For this reason, therapies that are delivered to the fetus before birth hold promise to treat diseases prior to or in the early stages of...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Kelsey Swingle, Margaret Billingsley, William Peranteau
Keywords(s): Bioengineering, Cell Therapy, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Nanotechnology, Orphan Disease, Platform Technology
Category(s): Technology Classifications > Therapeutics
Modified Lipid Nanoparticle Formulations with Improved Therapeutic Delivery to the Bone Microenvironment In-vivo
A library of bi-phosphonate ionizable lipids and LNP formulations to facilitate mRNA delivery to the bone microenvironment. Problem: The increasing prevalence of skeletal diseases such as osteoporosis, osteoarthritis and bone cancer have motivated efforts to target the bone microenvironment therapeutically. However, therapeutic agents must overcome...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Lulu Xue
Keywords(s): Drug Delivery, Drug Target, Nanotechnology, Orthopedics, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Vaccines, Technology Classifications > Therapeutics, Technology Classifications > Research Tools & Reagents
Ligand-Tethered Lipid Nanoparticles for Targeted RNA Delivery to Treat Liver Fibrosis
A new class of anisimide-functionalized lipids that enables targeted delivery of lipid nanoparticles (LNPs) to activated fibroblasts in the liver. Problem: Lipid nanoparticles (LNPs) have been successfully used in FDA-approved therapies to deliver messenger RNA (mRNA) and small interfering RNA (siRNA) . One of the biggest challenge in developing...
Published: 2/7/2024   |   Inventor(s): Michael Mitchell, Xuexiang Han
Keywords(s): Bioengineering, Drug Delivery, Gene Editing, Gene Therapy, Genetic Disorders, Immunology, Immunoncology, Platform Technology, Regenerative Medicine
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Vaccines
Microfluidic device for large-scale production of lipid nanoparticles
​A scalable, parallelized, multi-channel microfluidic device for generating lipid nanoparticles. Problem: Lipid nanoparticles are a promising delivery technology for RNA therapeutics and vaccines. However, there is a lack of formulation strategies that can produce nanoparticles with precisely defined properties that have scalable throughputs ranging...
Published: 10/16/2023   |   Inventor(s): Michael Mitchell, David Issadore, Sarah Shepherd, Sagar Yadavali
Keywords(s): Bioengineering, Drug Delivery, Microfluidics, Nanotechnology
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Materials
Lipid nanoparticle-based mRNA delivery for CAR T-cell engineering
A library of ionizable lipid nanoparticles (LNPs) was screened for ability to deliver mRNA to T-cells, leading to an optimized LNP formulation for delivery of mRNA to T-cells. This thereby enhances the ability to generate transient chimeric antigen receptor (CAR)-expressing T-cells for cancer immunotherapy. Problem: Chimeric antigen receptor (CAR)...
Published: 1/23/2024   |   Inventor(s): Margaret Billingsley, Carl June, Nathan Singh, Michael Mitchell
Keywords(s): Bioengineering, COVID-19, Drug Delivery, Immunology, Immunotherapy
Category(s): Technology Classifications > Therapeutics
Rapid Method to Design and Screen Novel Lipid Nanoparticles for mRNA Delivery In Vivo
A platform technology to rapidly identify novel lipid nanoparticle (LNP) formulations to carry mRNA-based therapeutics to target organs/cells in vivo. Problem: Messenger RNA (mRNA) has emerged as a promising new class of nucleic acid therapy, with the potential to induce protein production to treat and prevent a range of diseases. While significant...
Published: 1/23/2024   |   Inventor(s): Michael Mitchell, Rui Zhang, Roman Spektor
Keywords(s): Bioengineering, COVID-19
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents, Technology Classifications > Therapeutics
Portable Uv Water Treatment System
A portable water purification system and method of operation of the system is disclosed that may comprise a container defining a water purification chamber; a plurality of UV generating light sources distributed in the purification chamber of the container; and a portable power source electrically connected to the light sources, and adapted to convert...
Published: 4/26/2021   |   Inventor(s): Nicole Migliore, Michael Mitchell, Joanna Sweetgall, Amanda Grimes, Vikki Hazelwood
Keywords(s):  
Category(s): Bio Technology (Rx, dev's, sys)