Search Results - microbiome

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Microbial Metabolites for Promoting Brain Health (UCLA Case No. 2024-196)
UCLA researchers in the Department of Integrative Biology and Physiology have developed a maternal supplementation with microbiome-dependent metabolites to promote growth and neurobehavioral health in children impacted by maternal protein undernutrition. BACKGROUND: Protein undernutrition poses a significant risk of childhood stunting, accompanying...
Published: 12/12/2024   |   Inventor(s): Elaine Hsiao
Keywords(s): Brain, brain health, growth defects, malnutrition, maternal supplementation, microbial metabolites, microbiome, neurobehavioral impairment, neurodevelopment, nutrition, protein undernutrition, stunting
Category(s): Therapeutics > CNS and Neurology, Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health
Compounds for Improved Psychological and Resilience Measures Associated with Physical Activity (UCLA Case No. 2022-272)
UCLA researchers from the Department of Medicine have identified microbiome and metabolic markers associated with high physical activity in an obese population, leading to possible therapies that may provide the positive effects of physical activity. BACKGROUND: It is known that physical activity has a multitude of beneficial effects on health. On...
Published: 11/18/2024   |   Inventor(s): Arpana Church
Keywords(s): Bacteria, Exercise, Gastroenterology & Digestive Disease, gut-brain axis, Human Gastrointestinal Tract, metabolomics, microbiome, MRI, Nutraceuticals / Probiotics, obesity, physical activity, prebiotics, Psychology
Category(s): Therapeutics > Gastroenterology, Therapeutics > Psychiatry And Mental Health, Therapeutics > Metabolism And Endocrinology
An iron oxide nanozyme formulation for augmenting the efficacy of oral care products.
A combinatory formulation for oral care products that enhances antimicrobial specificity, anti-plaque potency and prevents tooth decay. Problem: Tooth decay (dental caries), caused by the destruction of the outer layer (enamel) of teeth by bacteria in biofilms, affects nearly half of the global population and remains the most prevalent chronic disease...
Published: 10/8/2024   |   Inventor(s): Yue Huang, Hyun (Michel) Koo, David Cormode
Keywords(s): Bioengineering, Dentistry, Infectious Disease, Microbiome, Nanotechnology, Platform Technology
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Materials, Technology Classifications > Therapeutics
Dissecting Microbiota-Gut-Brain Interactions for the Anti-Seizure Effects of the Ketogenic Diet (UCLA Case No. 2025-006)
UCLA researchers from the Department of Integrative Biology & Physiology have identified specific components of ketogenic diets that alter the microbiome and improve seizure resistance, providing valuable data to optimize diet treatments for refractory epilepsy. BACKGROUND: Refractory epilepsy, a disease characterized by uncontrolled seizures,...
Published: 9/19/2024   |   Inventor(s): Elaine Hsiao
Keywords(s): diet, dietary fiber, Epilepsy, gut, gut-brain axis, ketogenic diet, microbiome, pediatrics, seizure
Category(s): Therapeutics > Gastroenterology, Therapeutics > CNS and Neurology, Therapeutics > Metabolism And Endocrinology
Nisin-Based Formulations for Oral and Systemic Conditions (UCLA Case Nos. 2023-133 and 2022-306)
UCLA researchers in the Department of Dentistry have found a novel use for nisin alone, and in formulations, for use in the treatment of Alzheimer’s disease, and multiple inflammation states such as brain inflammation, joint inflammation, oral inflammation, systemic inflammation, inflammatory bowel diseases, and non-alcoholic fatty liver disease...
Published: 9/19/2024   |   Inventor(s): Yvonne Kapila
Keywords(s): Alzheimers disease, Antibacterial, gut inflammation, Inflammation, microbiome, nanoparticle delivery system, Nanoparticles, nisin, oral inflammation, periodontal disease, periodontal inflammation, periodontal regeneration
Category(s): Therapeutics > CNS and Neurology
Antimicrobial Peptides (AMPs) Mined from Human Gut Metagenome Are Effective Against Antibiotic Resistant Pathogens
The collective genomes of the human gut microbiome, known as the metagenome, encode peptides that are effective against antibiotic-resistant bacteria. Problem: Antimicrobial resistance poses a major threat to public health. The development of drug-resistance outpaces traditional drug discovery approaches. As a result, the supply of drugs available to...
Published: 6/26/2024   |   Inventor(s): Cesar de la Fuente-Nunez, Marcelo Der Torossian Torres, Ami Bhatt, Erin Brooks
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Bioengineering, Infectious Disease, Microbiome, Protein/Peptide (Non-Antibody)
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Therapeutics
New Postbiotics for Skin Health
­Advantages: Developed unique strains of postbiotics that offer a safer alternative to live probiotics for improving overall skin health. Enhanced wound healing effects in animal studies Strains can go into any formulation for skin health or cosmetics, e.g. body wash, soap, shampoo, oils, cream etc.. Summary: The escalating issue of slow...
Published: 5/16/2024   |   Inventor(s): Hariom Yadav, Shalini Jain, Santosh Prajapati, Atul Chander
Keywords(s): Microbiome, Wound and Tissue Healing
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Biotechnology
Lung Microbiome Isolation and Cultivation
­Competitive Advantages: Novel method to isolate, cultivate, and amplify the lung microbiome from a limited resource Beneficial for testing antibiotic sensitivity and drug resistance Enables lung microbiome transplantation for treatment of various chronic lung diseases Summary: Chronic lung diseases such as asthma, COPD, cystic fibrosis,...
Published: 11/25/2024   |   Inventor(s): Andreas Seyfang, Nirmal Sharma
Keywords(s): Cancer Treatment Lung Cancer, Health Tech, Microbiome
Category(s): Technology Classifications > Medical > Respiratory