Search Results - transplantation

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IL7Rα-Specific Antibody for Treating Acute Lymphoblastic Leukemia (ALL)
Abstract: Acute lymphoblastic leukemia (ALL) is the most common cancer in children with approximately 3,250 new cases occurring per year in the United States. About 20% of cases are refractory to current treatment protocols and there is a desperate need for targeted therapies that do not result in adverse side effects such as cognitive impairment.  The...
Published: 4/8/2024   |   Inventor(s): Scott Durum, Julie Hixon, Wenqing Li, Scotch Walsh, Lila Kashi
Keywords(s): Acute lymphoblastic leukemia (ALL), ANTIBODY, Antibody-Dependent Cellular Cytotoxicity (ADCC), Autoimmunity, CANCER, DIABETES, Durum, Interleukin-7 receptor-α (IL-7Rα), Multiple sclerosis, personalized medicine, Targeted therapy, THERAPY, TRANSPLANTATION
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration
Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages
Abstract: Researchers at the National Eye Institute (NEI) have discovered an invention describing a composition and method(s) of using such composition for preserving viability of cells, tissues, or organs at a low temperature (around 4ºC). Current cold storage solutions or methods for cells, tissues, and organs are suboptimal due to irreversible...
Published: 4/8/2024   |   Inventor(s): Jingxing Ou, Wei Li, Kiyoharu Miyagishima
Keywords(s): Cold Storage, Cold-sensitive, Hypothermia, lysosome, Mitochondria, National Eye Institute, NEI, neural injury, Ou, Protein Degradation, TRANSPLANTATION
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Nephrology
Regenerative Therapy for Cartilage Damage
The subject technology discloses a tissue engineering method for treating cartilage damage. Stem cells from bone marrow are attached to a novel scaffold, hyaluronic acid-coated fibrin microbeads, and transferred to a live host to form cartilage. The regenerated cartilage is stable and not hypertrophic, which has been problematic in the current regenerative...
Published: 8/21/2024   |   Inventor(s): Mitchell Shirvan, Rafael Gorodetsky, Sergei Kuznetsov, Astar Lazmi-Hailu, Pamela Robey
Keywords(s): Bone, Cartilage, Cells, Fibrin, Generation, Human, Hyaline, Marrow, Microbeads, STABLE, Stromal, TRANSPLANTATION, VAXXXX, Vivo, WJXXXX, XCXXXX, XDXXXX, YAXXXX, YBXXXX, YCXXXX
Category(s): Application > Diagnostics, Application > Research Materials, Application > Non-Medical Devices, Application > Therapeutics, TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, Application > Medical Devices
Methods of Inducing Immune Tolerance Using Immunotoxins
The invention concerns immunotoxins and methods of using the immunotoxins for the treatment of rejection response in a patient, including graft-versus-host disease and transplantation of organs, tissues and cells into a host. In a specific embodiment of the invention, the transplant involves pancreatic islet cells. The immunotoxins are targeted via...
Published: 7/25/2024   |   Inventor(s): David Neville
Keywords(s): Activity, Agents, CB1XXX, CBXXXX, Cell, COMBINED, CXXXXX, Dendritic, Graft versus host disease, IB3XXX, IBXXXX, IMMUNE, Immunotoxin, IMMUNOTOXINS, Induce, INDUCING, INHIBIT, IN-VIVO, ISLET, IXXXXX, Maturation, Methds, Method, Methods, Novel, Pancreatic, RELATED, SUPPRESSANT, T, That, TOLERANCE, TRANSPLANTATION
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Oncology, Application > Therapeutics
Treatment for Hypertension
Technology Description This technology opportunity provides antisense oligomer compounds and methods for the treatment of hypertension that overcome the various limitations and drawbacks associated with the use of substrate inhibitors. The compounds accumulate in the kidney, which allows for efficient dosing, and can be developed for transdermal, subcutaneous,...
Published: 1/16/2023   |   Inventor(s): Patrick Iversen, Andrew Annalora
Keywords(s): Hypertension, pharmaceuticals, Transplantation
Category(s): Therapeutics
Electrochemical Pressure Sensor
Pressure/force sensors and transducers have wide utility in mechanical, medical and industrial applications, with each industry striving for increased performance. Three key features determine how successful a pressure sensor may be: sensitivity, durability, and cost. Because of their robust and inexpensive nature, transformative electrochemical pressure/force...
Published: 2/23/2023   |   Inventor(s): Jeffrey LaBelle, Austin Feldman, Mary Siuba, Ross Carlton, Jeffrey Andrade
Keywords(s): Automotive, Bio-Technology, Brain and Machine Interface, Detection, Device, Flexible electronics, Sensors, Transplantation, Vascular
Category(s): Chemical/Biological Sensors, Life Science (All LS Techs), Medical Devices