Search Results - lysosome

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GENETICALLY ENCODED LYSOSOME TARGETING CHIMERAS FOR CELL-MEDIATED DELIVERY
GENETICALLY ENCODED LYSOSOME TARGETING CHIMERAS FOR CELL-MEDIATED DELIVERY Researchers at Stanford have developed fully genetically-encodable lysosome-targeting chimeras which allow for the targeted delivery of various proteins into receiver cells. Lysosome-targeted degradation is an emerging therapeutic modality that facilitates the degradation...
Published: 11/6/2024   |   Inventor(s): Jonathan Yang, Carolyn Bertozzi, Alice Ting
Keywords(s): Fusion Protein, Lysosome
Category(s): Technology Classifications > Biology
CNS Therapeutics That Target Neuronal Ceroid-Lipofuscinoses and Thioesterase Deficiency Disorders
Abstract: Clinically known as Neuronal Ceroid-Lipofuscinoses (NCL), Batten disease, is a rare neuron killing disease and one of the lysosomal storage disorders (LSDs).  It is associated with a mutation or lack of palmitoyl-protein thioesterase-1 (PPT1) gene. It manifests very early in a child's life causing absence of brain activity as early as 4 years...
Published: 4/8/2024   |   Inventor(s): Anil Mukherjee, Chinmoy Sarkar, Gary Zhongjian Zhang
Keywords(s): lysosomal storage disorders (LSD), lysosome, Neuronal Ceroid-Lipofuscinoses (NCL), Non-toxic derivative of hydroxylamine, Palmitoyl-protein thioesterase
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages
Abstract: Researchers at the National Eye Institute (NEI) have discovered an invention describing a composition and method(s) of using such composition for preserving viability of cells, tissues, or organs at a low temperature (around 4ºC). Current cold storage solutions or methods for cells, tissues, and organs are suboptimal due to irreversible...
Published: 12/6/2024   |   Inventor(s): Jingxing Ou, Wei Li, Kiyoharu Miyagishima
Keywords(s): Cold Storage, Cold-sensitive, Hypothermia, lysosome, Mitochondria, National Eye Institute, NEI, neural injury, Ou, Protein Degradation, TRANSPLANTATION
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Nephrology, TherapeuticArea > Ear, Nose, & Throat, TherapeuticArea > Ophthalmology